hBChE-IN-1
hBChE-IN-1 (compound 4), a quinolizidinyl derivative, is a potent hBChE inhibitor (IC50=7 nM) and highly selective over hAChE. hBChE-IN-1 shows inhibitory activity against tau and Aβ40 protein aggregation, with IC50 values of 20 and 4.3 μM, respectively. hBChE-IN-1 can be used for Alzheimer's disease research.
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- No. CAS: 1776948-12-9
- Fòrmula: C27H34N2OS2
- Peso molecular:466.70
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Actividad biológica
|
hBCHE 0.0070 ± 0 μM (IC50) |
equine serum BChE 0.088 μM (IC50) |
EeAChE 0.18 μM (IC50) |
hAChE 7.84 ± 0.8 μM (IC50) |
Chemical Information
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No. CAS 1776948-12-9
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Peso molecular 466.70
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Fòrmula C27H34N2OS2
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SMILES
[H][C@]12CCCCN1CCC[C@H]2CSCCCNC3=CC=C(C4=C3C(C5=CC=CC=C5S4)=O)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hBChE-IN-1 Related Classifications
HY-149273 Related Classifications
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