hBChE-IN-1
hBChE-IN-1 (compound 4), a quinolizidinyl derivative, is a potent hBChE inhibitor (IC50=7 nM) and highly selective over hAChE. hBChE-IN-1 shows inhibitory activity against tau and Aβ40 protein aggregation, with IC50 values of 20 and 4.3 μM, respectively. hBChE-IN-1 can be used for Alzheimer's disease research.
For research use only. We do not sell to patients.
- CAS No.: 1776948-12-9
- Formula: C27H34N2OS2
- Molecular Weight:466.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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hBCHE 0.0070 ± 0 μM (IC50) |
equine serum BChE 0.088 μM (IC50) |
EeAChE 0.18 μM (IC50) |
hAChE 7.84 ± 0.8 μM (IC50) |
Chemical Information
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CAS No. 1776948-12-9
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Molecular Weight 466.70
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Formula C27H34N2OS2
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SMILES
[H][C@]12CCCCN1CCC[C@H]2CSCCCNC3=CC=C(C4=C3C(C5=CC=CC=C5S4)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hBChE-IN-1 Related Classifications
HY-149273 Related Classifications
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