PBRM1-BD2-IN-7
PBRM1-BD2-IN-7 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-7 has inhibitory activity for PBRM1-BD2 with an IC50 value of 0.29 μM. PBRM1-BD2-IN-7 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2819989-68-7
- Formula: C16H15ClN2O
- Molecular Weight:286.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 0.29 μM (PBRM1-BD2)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LNCaP | IC50 |
2 μM
Compound: 26
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Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth measured after 7 days with compound replacement for every 48 hrs by celltiter-glo assay
Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth measured after 7 days with compound replacement for every 48 hrs by celltiter-glo assay
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[PMID: 36227159] |
| PC-3 | IC50 |
2 μM
Compound: 26
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Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth measured after 6 days with compound replacement for every 48 hrs by celltiter-glo assay
Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth measured after 6 days with compound replacement for every 48 hrs by celltiter-glo assay
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[PMID: 36227159] |
PBRM1-BD2-IN-7 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibit growth of a PBRM1-dependent prostate cancer cell line[1].
PBRM1-BD2-IN-7 has inhibitory activity for PBRM1-BD2 with IC50 value of 0.29 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human prostate cell lines LNCaP, PC3, and RWPE-1
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Concentration:0, 0.1, 1, and 10 μM
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Incubation Time:5 days
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Result:Inhibited LNCaP growth at higher concentrations.
Chemical Information
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CAS No. 2819989-68-7
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Molecular Weight 286.76
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Formula C16H15ClN2O
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SMILES
O=C1NC(C2=C(C)C=CC=C2C)NC3=C1C(Cl)=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PBRM1-BD2-IN-7 Related Classifications
HY-151534 Related Classifications
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