2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. HMGB1-IN-3

HMGB1-IN-3 (compound E) is a glycyrrhizic acid derivative with strong inhibitory activity against HMGB1 (high mobility group protein 1) and can be used in the study of intracerebral hemorrhage.

For research use only. We do not sell to patients.

HMGB1-IN-3

HMGB1-IN-3 Chemical Structure

CAS No. : 5195-71-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

HMGB1-IN-3 Related Antibodies

Top Publications Citing Use of Products

View All Toll-like Receptor (TLR) Isoform Specific Products:

View All Isoforms
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

HMGB1-IN-3 (compound E) is a glycyrrhizic acid derivative with strong inhibitory activity against HMGB1 (high mobility group protein 1) and can be used in the study of intracerebral hemorrhage[1].

Cellular Effect
Cell Line Type Value Description References
518A2 EC50
> 30 μM
Compound: 11
Cytotoxicity against human 518A2 cells assessed as cell survival after 96 hrs by SRB assay
Cytotoxicity against human 518A2 cells assessed as cell survival after 96 hrs by SRB assay
[PMID: 26177446]
518A2 IC50
> 30 μM
Compound: 11
Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
[PMID: 21959232]
8505C EC50
20.5 μM
Compound: 11
Cytotoxicity against human 8505C cells assessed as cell survival after 96 hrs by SRB assay
Cytotoxicity against human 8505C cells assessed as cell survival after 96 hrs by SRB assay
[PMID: 26177446]
8505C IC50
> 30 μM
Compound: 11
Cytotoxicity against human 8505C cells after 96 hrs by SRB assay
Cytotoxicity against human 8505C cells after 96 hrs by SRB assay
[PMID: 21959232]
A2780 IC50
> 30 μM
Compound: 11
Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
[PMID: 21959232]
A549 EC50
26.1 μM
Compound: 11
Cytotoxicity against human A549 cells assessed as cell survival after 96 hrs by SRB assay
Cytotoxicity against human A549 cells assessed as cell survival after 96 hrs by SRB assay
[PMID: 26177446]
A549 IC50
> 30 μM
Compound: 11
Cytotoxicity against human A549 cells after 96 hrs by SRB assay
Cytotoxicity against human A549 cells after 96 hrs by SRB assay
[PMID: 21959232]
DLD-1 IC50
> 30 μM
Compound: 11
Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
[PMID: 21959232]
HT-29 EC50
26.7 μM
Compound: 11
Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay
Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay
[PMID: 26177446]
MCF7 EC50
16.7 μM
Compound: 11
Cytotoxicity against human MCF7 cells assessed as cell survival after 96 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as cell survival after 96 hrs by SRB assay
[PMID: 26177446]
MCF7 IC50
> 30 μM
Compound: 11
Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
[PMID: 21959232]
NTUB1 IC50
56.5 μM
Compound: 3
Cytotoxicity against human NTUB1 cells after 72 hrs by MTT assay
Cytotoxicity against human NTUB1 cells after 72 hrs by MTT assay
[PMID: 21696969]
SW-1736 IC50
29.09 μM
Compound: 11
Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay
Cytotoxicity against human SW1736 cells after 96 hrs by SRB assay
[PMID: 21959232]
Molecular Weight

482.69

Formula

C31H46O4
CAS No.
SMILES

C[C@]1(C(OC)=O)CC[C@]([C@@]2([H])C1)(C)CC[C@@](C2=C3)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(CC[C@]5(C)[C@@]4([H])C3=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

HMGB1-IN-3 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HMGB1-IN-35195-71-1Toll-like Receptor (TLR)Inhibitorsglycyrrhizic acidderivativescerebral hemorrhageInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
HMGB1-IN-3
Cat. No.:
HY-168053
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.