country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-183044

Copy Link Print Information

SIRT1 activator 4

SIRT1 activator 4 is an orally active, NAD⁺-independent SIRT1 activator. SIRT1 activator 4 is also an analog of (E)-2'-desmethyl Sulindac (HY-B0008), with weak or negligible inhibitory activity against COX-1 and no inhibitory activity against COX-2. SIRT1 activator 4 can be used for the research of metabolic diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1049800-47-6
Formel: C₂₄H₁₇FO₂
Molecular Weight:356.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

SIRT1 activator 4 Chemical Structure

CAS. Nr.: 1049800-47-6

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

SIRT1

Alle Sirtuin Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	EC₅₀	141 μM Compound: 13a	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by WST1 assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by WST1 assay	[PMID: 22263894]

In Vivo

SIRT1 activator 4 (compound B) (5-50 mg/kg, p.o.; once daily for 3 consecutive days) dose-dependently activates the SIRT1 signaling pathway in mouse liver, exerts anti-inflammatory effects, stimulates gluconeogenesis, inhibits adipogenesis, and regulates clock gene expression, with no acute toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 J Mice (male, 8 months of age)^[1]
Dosage:

5 mg/kg/day; 50 mg/kg/day
Administration:

p.o.; daily; 3 days
Result:

Regulation of Gene Expression
1. Dose-dependently reduces levels of NF-κB target genes (e.g., Tnfα, Ccl2) and adipogenic genes (e.g., Acaca, Fasn); decreases expression of the glycolytic gene Gck.
2. Increases levels of gluconeogenic genes (e.g., Pgc1α, Pck1, G6pc), Fgf21, and Nampt; alters the expression of clock genes.

Metabolites: Decreases levels of gluconeogenic amino acids; increases levels of gluconeogenic intermediates, malate, and hepatic NAD⁺ (showing an upward trend).
Histology: Significantly reduces inflammatory cell infiltration in the liver.
Safety: With the exception of occasional mild hepatocyte hypertrophy observed in the high-dose group, no significant toxicity or changes in body weight were noted.

Chemical Information

CAS. Nr. 1049800-47-6
Molecular Weight 356.40
Formel C₂₄H₁₇FO₂
SMILES

C(=C\1/C=2C(C(CC(O)=O)=C1)=CC(F)=CC2)\C3=CC=C(C=C3)C4=CC=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Della Torre S, et al. Discovery and characterization of a new class of NAD⁺-independent SIRT1 activators. Pharmacol Res. 2024;206:107296. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen