SIRT1 activator 4
SIRT1 activator 4 is an orally active, NAD+-independent SIRT1 activator. SIRT1 activator 4 is also an analog of (E)-2'-desmethyl Sulindac (HY-B0008), with weak or negligible inhibitory activity against COX-1 and no inhibitory activity against COX-2. SIRT1 activator 4 can be used for the research of metabolic diseases.
For research use only. We do not sell to patients.
- CAS No.: 1049800-47-6
- Formula: C24H17FO2
- Molecular Weight:356.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SIRT1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | EC50 |
141 μM
Compound: 13a
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Cytotoxicity against human MDA-MB-231 cells after 48 hrs by WST1 assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by WST1 assay
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[PMID: 22263894] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 J Mice (male, 8 months of age)[1]
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Dosage:5 mg/kg/day; 50 mg/kg/day
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Administration:p.o.; daily; 3 days
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Result:Regulation of Gene Expression
1. Dose-dependently reduces levels of NF-κB target genes (e.g., Tnfα, Ccl2) and adipogenic genes (e.g., Acaca, Fasn); decreases expression of the glycolytic gene Gck.
2. Increases levels of gluconeogenic genes (e.g., Pgc1α, Pck1, G6pc), Fgf21, and Nampt; alters the expression of clock genes.
Metabolites: Decreases levels of gluconeogenic amino acids; increases levels of gluconeogenic intermediates, malate, and hepatic NAD+ (showing an upward trend).
Histology: Significantly reduces inflammatory cell infiltration in the liver.
Safety: With the exception of occasional mild hepatocyte hypertrophy observed in the high-dose group, no significant toxicity or changes in body weight were noted.
Chemical Information
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CAS No. 1049800-47-6
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Molecular Weight 356.40
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Formula C24H17FO2
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SMILES
C(=C\1/C=2C(C(CC(O)=O)=C1)=CC(F)=CC2)\C3=CC=C(C=C3)C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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