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Cat. No.: HY-151376

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SAP2-IN-1

SAP2-IN-1 is a secreted aspartic protease 2 (SAP2) inhibitor and has potent SAP2 inhibitory activity with an IC₅₀ value of 0.92 μM. SAP2-IN-1 also is a virulence factor inhibitor and is inactive in vitro. SAP2-IN-1 can be used for the research of infection.

For research use only. We do not sell to patients.

CAS No.: 2512847-37-7
Formula: C₃₄H₂₉NO₇
Molecular Weight:563.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

SAP2-IN-1 Chemical Structure

CAS No.: 2512847-37-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 0.92 μM (SAP2)^[1]

In Vitro

SAP2-IN-1 (compound 24a) (100 μM) shows potent SAP2 inhibitory activity with an IC₅₀ value of 0.92 μM^[1].
SAP2-IN-1 (100 μM) has not inhibit the growth of C. albicans and inactive in vitro^[1].
SAP2-IN-1 (64 μg/mL) blocks fungi biofilm and hypha formation by down-regulating the expression of genes SAP2, ECE1, ALS3 and EFG1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

C. albicans cells
Concentration:

64 μg/mL
Incubation Time:
Result:

Inhibited hypha growth through the cAMP-dependent pathway.

In Vivo

SAP2-IN-1 (compound 24a) (i.p.; 10 mg/kg; once daily; for four days) shows potent in vivo efficacy in a murine model of invasive candidiasis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

a murine model of invasive candidiasis^[1]
Dosage:

10 mg/kg
Administration:

intraperitoneally administration, once daily, for four days
Result:

Significantly reduced the fungal burden in the kidney.

Chemical Information

CAS No. 2512847-37-7
Molecular Weight 563.60
Formula C₃₄H₂₉NO₇
SMILES

CC1=CC=C(C2=CC=C(/C(C3=O)=C\C4=CC=C(OCC(O)=O)C=C4OCC(O)=O)C(N3CC5=CC=C(C)C=C5)=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chenglan Li, et al. Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors. Eur J Med Chem. 2020 Sep 1;201:112515. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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