1. Metabolic Enzyme/Protease
  2. Proteasome
  3. SAP2-IN-1

SAP2-IN-1 is a secreted aspartic protease 2 (SAP2) inhibitor and has potent SAP2 inhibitory activity with an IC50 value of 0.92 μM. SAP2-IN-1 also is a virulence factor inhibitor and is inactive in vitro. SAP2-IN-1 can be used for the research of infection.

For research use only. We do not sell to patients.

SAP2-IN-1 Chemical Structure

SAP2-IN-1 Chemical Structure

CAS No. : 2512847-37-7

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Description

SAP2-IN-1 is a secreted aspartic protease 2 (SAP2) inhibitor and has potent SAP2 inhibitory activity with an IC50 value of 0.92 μM. SAP2-IN-1 also is a virulence factor inhibitor and is inactive in vitro. SAP2-IN-1 can be used for the research of infection[1].

IC50 & Target

IC50: 0.92 μM (SAP2)[1]

In Vitro

SAP2-IN-1 (compound 24a) (100 μM) shows potent SAP2 inhibitory activity with an IC50 value of 0.92 μM[1].
SAP2-IN-1 (100 μM) has not inhibit the growth of C. albicans and inactive in vitro[1].
SAP2-IN-1 (64 μg/mL) blocks fungi biofilm and hypha formation by down-regulating the expression of genes SAP2, ECE1, ALS3 and EFG1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: C. albicans cells
Concentration: 64 μg/mL
Incubation Time:
Result: Inhibited hypha growth through the cAMP-dependent pathway.
In Vivo

SAP2-IN-1 (compound 24a) (i.p.; 10 mg/kg; once daily; for four days) shows potent in vivo efficacy in a murine model of invasive candidiasis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: a murine model of invasive candidiasis[1]
Dosage: 10 mg/kg
Administration: intraperitoneally administration, once daily, for four days
Result: Significantly reduced the fungal burden in the kidney.
Molecular Weight

563.60

Formula

C34H29NO7

CAS No.
SMILES

CC1=CC=C(C2=CC=C(/C(C3=O)=C\C4=CC=C(OCC(O)=O)C=C4OCC(O)=O)C(N3CC5=CC=C(C)C=C5)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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SAP2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
SAP2-IN-1
Cat. No.:
HY-151376
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