PAN endonuclease-IN-3
PAN endonuclease-IN-3 is a potent PAN endonuclease inhibitor that against influenza virus polymerase complexes with an IC50 of 17.4 nM. PAN endonuclease-IN-3 demonstrates potent inhibitory activities against PAN endonuclease. PAN endonuclease-IN-3 demonstrates robust antiviral activities against multiple current and different influenza virus strains while showing minimal cytotoxicity in MDCK cells. PAN endonuclease-IN-3 significantly suppresses viral replication in an A/WSN/33 infected mouse model.
For research use only. We do not sell to patients.
- Formula: C26H23F2N3O4S
- Molecular Weight:511.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
PAN endonuclease-IN-3 (Compound 39-(S)) (1-10 μM) exhibits influenza A Virus (IAV) polymerase inhibitory potency in HEK-293T cells with an IC50 of 17.4 nM, which is comparable activity to Baloxavir (HY-109025A) (IC50 = 17.8 nM)[1].
PAN endonuclease-IN-3(1-103 nM) demonstrates potent inhibitory activities against PAN endonuclease with an IC50 value of 41.8 nM[1].
PAN endonuclease-IN-3 (46 μL/well, 72 h) demonstrates exceptional antiviral activities with an EC50 value of 0.21 nM in Madin-Darby canine kidney (MDCK) cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:A/WSN/33 infection model in female BALB/c mice (6-8 weeks old) (1 × 105 TCID50/mouse)
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Dosage:20 mg/kg
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Administration:Intranasal administration single dose
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Result:Inhibited viral replication.
Maintained normal alveolar structure in the lungs from treated mice.
Reduced infiltration in immune cell.
Chemical Information
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Molecular Weight 511.54
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Formula C26H23F2N3O4S
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SMILES
CC(C)N(C1(COC1)N([C@@H]2C3=C(SCC4=C(C(F)=CC=C42)F)C=CC=C3)N5C=C6)C(C5=C(O)C6=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PAN endonuclease-IN-3 Related Classifications
HY-174431 Related Classifications
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