PBRM1-BD2-IN-2
Based on 1 Customer Validation
PBRM1-BD2-IN-2 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-2 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. PBRM1-BD2-IN-2 can be used for the research of cancer.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 2819989-57-4
- Formula: C14H9Cl2FN2O
- Molecular Weight:311.14
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Kd: 9.3 μM (PBRM1-BD2), 10.1 μM (PBRM1-BD5), 18.4 μM (SMARCA2B), 69 μM (SMARCA4)[1].
IC50: 1.0 μM (PBRM1-BD2)[1].
PBRM1-BD2-IN-2 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibit growth of a PBRM1-dependent prostate cancer cell line[1].
PBRM1-BD2-IN-2 has binding affinity for PBRM1-BD2, PBRM1-BD5, SMARCA2B amd SMARCA4 with Kd values of 9.3 μM, 10.1 μM, 18.4 μM and 69 μM, respectively[1].
PBRM1-BD2-IN-2 has inhibitory activity for PBRM1-BD2 with IC50 value of 1.0 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human prostate cell lines LNCaP, PC3, and RWPE-1
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Concentration:0, 0.1, 1, and 10 μM
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Incubation Time:5 days
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Result:Inhibited LNCaP growth at higher concentrations.
Chemical Information
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CAS No. 2819989-57-4
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Appearance Solid
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Molecular Weight 311.14
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Formula C14H9Cl2FN2O
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Color White to off-white
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SMILES
O=C1NC(C2=C(F)C=CC=C2Cl)NC3=C1C(Cl)=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 45 mg/mL (144.63 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2140 mL | 16.0699 mL | 32.1399 mL | 80.3497 mL |
| 5 mM | 0.6428 mL | 3.2140 mL | 6.4280 mL | 16.0699 mL | |
| 10 mM | 0.3214 mL | 1.6070 mL | 3.2140 mL | 8.0350 mL | |
| 15 mM | 0.2143 mL | 1.0713 mL | 2.1427 mL | 5.3566 mL | |
| 20 mM | 0.1607 mL | 0.8035 mL | 1.6070 mL | 4.0175 mL | |
| 25 mM | 0.1286 mL | 0.6428 mL | 1.2856 mL | 3.2140 mL | |
| 30 mM | 0.1071 mL | 0.5357 mL | 1.0713 mL | 2.6783 mL | |
| 40 mM | 0.0803 mL | 0.4017 mL | 0.8035 mL | 2.0087 mL | |
| 50 mM | 0.0643 mL | 0.3214 mL | 0.6428 mL | 1.6070 mL | |
| 60 mM | 0.0536 mL | 0.2678 mL | 0.5357 mL | 1.3392 mL | |
| 80 mM | 0.0402 mL | 0.2009 mL | 0.4017 mL | 1.0044 mL | |
| 100 mM | 0.0321 mL | 0.1607 mL | 0.3214 mL | 0.8035 mL |
PBRM1-BD2-IN-2 Related Classifications
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