N-PTyrosine PA ammonium  (Synonyms: N-Palmitoyl-tyrosine phosphoric acid ammonium)

N-PTyrosine PA (N-Palmitoyl-tyrosine phosphoric acid) ammonium is a lysophosphatidic acid (LPA) receptor modulator, which exhibits weak inhibitory activity against LPA1 and partial agonist properties towards LPA5. N-PTyrosine PA ammonium inhibits the activation of LPA receptors and downstream responses by competing with agonists for binding sites. N-PTyrosine PA ammonium can induce morphological changes and aggregation, and also inhibit LPA-induced morphological changes through receptor desensitization caused by pre-incubation. N-PTyrosine PA ammonium can be used in the research of related diseases such as atherosclerosis and acute ischemic syndromes (e.g., unstable angina, myocardial infarction, stroke)^[1][2][3].

N-PTyrosine PA ammonium (1 μM; 10 min) inhibits the lysophosphatidic acid receptor-mediated oscillatory inward Cl^- current by 69.8% in non-injected Xenopus oocytes, and this inhibition is fully reversible after washing^[1].
N-PTyrosine PA ammonium induces morphological changes in human platelets with an EC₅₀ of 0.2-0.3 μM; after 30 min of pre-incubation, N-PTyrosine PA ammonium inhibits LPA-induced morphological changes in human platelets with an IC₅₀ of 0.2-0.3 μM^[2].
N-PTyrosine PA ammonium acts as a partial micromolar agonist of the LPA₅ receptor in transiently transfected RH7777 cells, exerts weak inhibitory activity against the LPA₁ receptor in stably transfected RH7777 cells with a K_i of 533 nM, and shows no activity towards the LPA₂, LPA₃ or LPA₄ receptor^[2].
N-PTyrosine PA ammonium (10-30 μM; 5 min) does not induce Na⁺-dependent Ca²⁺ efflux in cultured bovine adrenal chromaffin cells at a concentration of 10 μM, nor does it inhibit 18:1-LPA (HY-157725)-stimulated Ca²⁺ efflux at concentrations of 10 μM or 30 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

516.61

C₂₅H₄₅N₂O₇P

799268-45-4

CCCCCCCCCCCCCCCC(N[C@H](C(O)=O)CC1=CC=C(C=C1)OP(O)(O)=O)=O.N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Stankiewicz M, et al. Effects of a centipede venom fraction on insect nervous system, a native Xenopus oocyte receptor and on an expressed Drosophila muscarinic receptor. Toxicon. 1999;37(10):1431-1445.

  [2]. Khandoga AL, et al. Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin. Platelets. 2008;19(6):415-427.

  [3]. Tokumura A, et al. Positive and negative controls by protein kinases of sodium-dependent Ca2+ efflux from cultured bovine adrenal chromaffin cells stimulated by lysophosphatidic acid. Biochim Biophys Acta. 1998;1389(1):67-75.