799268-45-4
Chemical Structure
N-PTyrosine PA ammonium
Synonym(s): N-Palmitoyl-tyrosine phosphoric acid ammonium
- CAS No.: 799268-45-4
- Formula:C25H45N2O7P
- Molecular Weight:516.61
IUPAC Name: (S)-2-palmitamido-3-(4-(phosphonooxy)phenyl)propanoic acid, ammonia salt
InChIKey: UZKHSMRJEHXEHO-BQAIUKQQSA-N
SMILES: CCCCCCCCCCCCCCCC(N[C@H](C(O)=O)CC1=CC=C(C=C1)OP(O)(O)=O)=O.N
Biological Activity: N-PTyrosine PA (N-Palmitoyl-tyrosine phosphoric acid) ammonium is a lysophosphatidic acid (LPA) receptor modulator, which exhibits weak inhibitory activity against LPA1 and partial agonist properties towards LPA5. N-PTyrosine PA ammonium inhibits the activation of LPA receptors and downstream responses by competing with agonists for binding sites. N-PTyrosine PA ammonium can induce morphological changes and aggregation, and also inhibit LPA-induced morphological changes through receptor desensitization caused by pre-incubation. N-PTyrosine PA ammonium can be used in the research of related diseases such as atherosclerosis and acute ischemic syndromes (e.g., unstable angina, myocardial infarction, stroke)[1][2][3].
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N-PTyrosine PA ammonium | N-PTyrosine PA (N-Palmitoyl-tyrosine phosphoric acid) ammonium is a lysophosphatidic acid (LPA) receptor modulator, which exhibits weak inhibitory activity against LPA1 and partial agonist properties towards LPA5. N-PTyrosine PA ammonium inhibits the activation of LPA receptors and downstream responses by competing with agonists for binding sites. N-PTyrosine PA ammonium can induce morphological changes and aggregation, and also inhibit LPA-induced morphological changes through receptor desensitization caused by pre-incubation. N-PTyrosine PA ammonium can be used in the research of related diseases such as atherosclerosis and acute ischemic syndromes (e.g., unstable angina, myocardial infarction, stroke). | |||||||||||||||||||||
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References
- [1]. Stankiewicz M, et al. Effects of a centipede venom fraction on insect nervous system, a native Xenopus oocyte receptor and on an expressed Drosophila muscarinic receptor. Toxicon. 1999;37(10):1431-1445. [Content Brief]
- [2]. Khandoga AL, et al. Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin. Platelets. 2008;19(6):415-427. [Content Brief]
- [3]. Tokumura A, et al. Positive and negative controls by protein kinases of sodium-dependent Ca2+ efflux from cultured bovine adrenal chromaffin cells stimulated by lysophosphatidic acid. Biochim Biophys Acta. 1998;1389(1):67-75. [Content Brief]
