AZD-3289
AZD-3289 is a potent BACE1 inhibitor with potential Alzheimer's disease inhibitory activity. The application of AZD-3289 is intended to slow the pathological progression of Alzheimer's disease by inhibiting the production of β-amyloid protein. The development of AZD-3289 responds to the need to reduce neurodegenerative changes associated with Alzheimer's disease. As a BACE1 inhibitor, AZD-3289 can effectively reduce the accumulation of β-amyloid peptide in the brain, which may improve cognitive function.
For research use only. We do not sell to patients.
- CAS No.: 1227163-49-6
- Formula: C24H14F5N5
- Molecular Weight:467.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Cerebral cortex neuron | IC50 |
204 nM
Compound: (S)-10
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Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISA
Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISA
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[PMID: 22924815] |
| CHO | IC50 |
7.9 μM
Compound: (S)-10
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Inhibition of human ERG expressed in CHO cells by IonWorks assay
Inhibition of human ERG expressed in CHO cells by IonWorks assay
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[PMID: 22924815] |
| SH-SY5Y | IC50 |
22.1 nM
Compound: (S)-10
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Inhibition of BACE1 in human SH-SY5Y cells assessed as inhibition of sAPPbeta release after 16 hrs by immunoassay
Inhibition of BACE1 in human SH-SY5Y cells assessed as inhibition of sAPPbeta release after 16 hrs by immunoassay
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[PMID: 22924815] |
Chemical Information
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CAS No. 1227163-49-6
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Molecular Weight 467.39
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Formula C24H14F5N5
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SMILES
NC1=N[C@@](C2=CC(C3=CN=CN=C3)=C(C=C2)F)(C4=CC=NC(C(F)(F)F)=C4)C5=CC=CC(F)=C51
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AZD-3289 Related Classifications
HY-116580 Related Classifications
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