1227163-49-6
Chemical Structure
AZD-3289
- CAS No.: 1227163-49-6
- Formula:C24H14F5N5
- Molecular Weight:467.39
IUPAC Name: (S)-4-fluoro-1-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine
InChIKey: UDQUVXUVXUGJFO-QHCPKHFHSA-N
SMILES: NC1=N[C@@](C2=CC(C3=CN=CN=C3)=C(C=C2)F)(C4=CC=NC(C(F)(F)F)=C4)C5=CC=CC(F)=C51
Biological Activity: AZD-3289 is a potent BACE1 inhibitor with potential Alzheimer's disease inhibitory activity. The application of AZD-3289 is intended to slow the pathological progression of Alzheimer's disease by inhibiting the production of β-amyloid protein. The development of AZD-3289 responds to the need to reduce neurodegenerative changes associated with Alzheimer's disease. As a BACE1 inhibitor, AZD-3289 can effectively reduce the accumulation of β-amyloid peptide in the brain, which may improve cognitive function[1].
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AZD-3289 | AZD-3289 is a potent BACE1 inhibitor with potential Alzheimer's disease inhibitory activity. The application of AZD-3289 is intended to slow the pathological progression of Alzheimer's disease by inhibiting the production of β-amyloid protein. The development of AZD-3289 responds to the need to reduce neurodegenerative changes associated with Alzheimer's disease. As a BACE1 inhibitor, AZD-3289 can effectively reduce the accumulation of β-amyloid peptide in the brain, which may improve cognitive function. | |||||||||||||||||||||
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