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United States

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製品番号: HY-151502

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Antimicrobial agent-12

Antimicrobial agent-12 is a potent antibacterial agent with SARS-CoV-2 inhibitory activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₆₉H₆₁Cl₂F₃N₁₀O₂₅
分子量:1558.18

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

Antimicrobial agent-12 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Antimicrobial agent-12 is a potent antibacterial agent with SARS-CoV-2 inhibitory activity^[1].

IC₅₀ & Target

Bacteria, SARS-CoV-2^[1]

体外実験

Antimicrobial agent-12 (compound 6) shows inhibitory activity on coronavirus (SARS-CoV-2) replication and spike-mediated pseudovirus entry in Vero E6 cells, with EC₅₀ values of 13 μM^[1].
Antimicrobial agent-12 inhibits 3CL^Pro enzyme activity and the ACE2-spike interaction, with EC₅₀ values of 28 μM and 48 μM respectively^[1].
Antimicrobial agent-12 (0-1 μg/mL approximately) shows activity against diverse species of Gram-positive bacteria including drug-resistant strains^[1].
Antimicrobial agent-12 (0-100 μM, 2 h) inhibits SARS-CoV-2 pseudovirus entry in Vero and A549-AT cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

S. aureus, E. faecalis, E. faecium, S. epidermidis, S. haemolyticus
Concentration:

0-1 μg/mL approximately
Incubation Time:
Result:

Inhibited bacteria activities with MIC values of 0.0625-0.27 μg/mL.

化学情報

分子量 1558.18
分子式 C₆₉H₆₁Cl₂F₃N₁₀O₂₅
SMILES

OC1=C(OC2=C(C=C(C=C2)[C@@]([H])(O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC(C)=O)[C@]([H])(NC([C@@H]4N5)=O)C(N[C@H](C6=CC(O)=CC(O)=C6C7=CC4=CC=C7O)C(O)=O)=O)Cl)C=C(C=C1OC8=C(C=C(C=C8)C[C@]([H])9NC([C@@H]%10NC(N)=N)=O)Cl)[C@H](C5=O)NC([C@@H](NC9=O)C%11=CC(OC%12=CC%10=CC=C%12O)=CC(O)=C%11)=O.FC(C(O)=O)(F)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (280 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ilona Bereczki, et al. Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteria. Sci Rep. 2022 Sep 26;12(1):16001. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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