2. Membrane Transporter/Ion Channel
  3. HCN Channel
  4. HCN2-IN-5

HCN2-IN-5 is a HCN2 ion channel inhibitor with an IC50 of 9 nM. HCN2-IN-5 shows weak inhibitory activity for HCN4. HCN2-IN-5 can be used for the research of inflammatory disease and neurological disorders.

For research use only. We do not sell to patients.

HCN2-IN-5

HCN2-IN-5 Chemical Structure

CAS No. : 3080808-86-9

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HCN2-IN-5 Related Antibodies

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Description

HCN2-IN-5 is a HCN2 ion channel inhibitor with an IC50 of 9 nM. HCN2-IN-5 shows weak inhibitory activity for HCN4. HCN2-IN-5 can be used for the research of inflammatory disease and neurological disorders[1].

IC50 & Target[1]

HCN2

9 nM (IC50)

HCN4

376 nM (IC50)

HCN1

>33750 nM (IC50)

In Vitro

HCN2-IN-5 (Compound 22) potently inhibits human HCN2 channels with an IC50 of 9 nM, inhibits human HCN4 channels with an IC50 of 376 nM, and does not significantly inhibit human HCN1 channels (IC50 >33750 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HCN2-IN-5 Related Antibodies
Molecular Weight

471.92

Formula

C21H18ClN5O4S
CAS No.
SMILES

O=C(C1=CC=NS1)NC2=NN(CC(C)OC)C3=NC=C(C4=C(Cl)C5=C(OCO5)C=C4)C=C23
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HCN2-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HCN2-IN-53080808-86-9HCN ChannelHyperpolarization activated cyclic nucleotide gated channelscentral nervous system disordershuman HCN1 channelspsychiatric disorderstinnitusHCN2 ion channelhuman HCN2 channelshuman HCN4 channelsmood disordersneuropathic paininflammatory painInhibitorinhibitorinhibit

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HY-186057
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