1. Anti-infection
  2. HIV
  3. HIV-1 inhibitor-16

HIV-1 inhibitor-16 

Cat. No.: HY-144123
Handling Instructions

HIV-1 inhibitor-16 (compound 7a) is a highly potent HIV-1 inhibitor with an EC50 value of 1.3 nM for HIV-1 WT. HIV-1 inhibitor-16 also has certain inhibitory activity against HIV-1 K103N, E138K, Y181C and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM and 35 nM. HIV-1 inhibitor-16 has favorable solubility and liver microsome stability, and does not exhibit apparent CYP enzymatic inhibitory activity or acute toxicity.

For research use only. We do not sell to patients.

HIV-1 inhibitor-16 Chemical Structure

HIV-1 inhibitor-16 Chemical Structure

CAS No. : 2719675-72-4

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Description

HIV-1 inhibitor-16 (compound 7a) is a highly potent HIV-1 inhibitor with an EC50 value of 1.3 nM for HIV-1 WT. HIV-1 inhibitor-16 also has certain inhibitory activity against HIV-1 K103N, E138K, Y181C and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM and 35 nM. HIV-1 inhibitor-16 has favorable solubility and liver microsome stability, and does not exhibit apparent CYP enzymatic inhibitory activity or acute toxicity[1].

IC50 & Target[1]

HIV-1 (WT)

1.3 nM (EC50)

HIV-1 (K103N)

5.4 nM (EC50)

HIV-1 (E138K)

9.2 nM (EC50)

HIV-1 (Y181C)

22 nM (EC50)

HIV-1 (L100I)

35 mM (EC50)

Molecular Weight

414.41

Formula

C23H16F2N6

CAS No.
SMILES

N#CC1=CC=C(NC2=NC=C(C)C(NC3=C(F)C=C(C4=CC=NC=C4)C=C3F)=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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HIV-1 inhibitor-16
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HY-144123
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