HIV-1 inhibitor-51
HIV-1 inhibitor-51, a non-nucleoside reverse transcriptase inhibitor (NNRTI), exhibits outstanding antiviral activity against WT HIV-1 (IIIB) and a panel of mutant strains. HIV-1 inhibitor-51 has high binding affinity (KD=2.50 μM) and inhibitory activity (IC50=0.03 μM) to WT HIV-1 RT. HIV-1 inhibitor-51 has EC50s of 2.22-53.3 nM for mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L + V106A, RES056).
For research use only. We do not sell to patients.
- CAS No.: 2834087-82-8
- Formula: C24H19ClFN5O2
- Molecular Weight:463.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIV-1 (WT) 0.03 μM (IC50) |
HIV-1 (WT) 2.5 μM (Kd) |
HIV-1 (L100I) 3.04 nM (EC50) |
HIV-1 (K103N) 2.87 nM (EC50) |
HIV-1 (Y181C) 10.2 nM (EC50) |
HIV-1 (Y188L) 13.2 nM (EC50) |
HIV-1 (E138K) 9.77 nM (EC50) |
HIV-1 (F227L+V106A) 19.8 nM (EC50) |
HIV-1 (RES056) 53.3 nM (EC50) |
HIV-1 inhibitor-51 (10 mg/kg; orally) has a T1/2 of 5.12 hours, and Cmax of 37.5 ng/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice[1]
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Dosage:2 mg/kg (Pharmacokinetic Analysis)
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Administration:IV
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Result:Had a T1/2 of 5.12 hours, and Cmax of 37.5 ng/mL.
Chemical Information
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CAS No. 2834087-82-8
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Molecular Weight 463.89
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Formula C24H19ClFN5O2
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SMILES
FC(C=C1NC2=NC(OC3=C(C=C(C=C3C)/C=C/C#N)C)=C4C(COC4)=N2)=C(C=C1)C#N.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-1 inhibitor-51 Related Classifications
HY-152161 Related Classifications
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