2834087-82-8
Chemical Structure
HIV-1 inhibitor-51
- CAS No.: 2834087-82-8
- Formula:C24H19ClFN5O2
- Molecular Weight:463.89
IUPAC Name: (E)-4-((4-(4-(2-cyanovinyl)-2,6-dimethylphenoxy)-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)amino)-2-fluorobenzonitrile hydrochloride
InChIKey: CBUZARNVPFYBDA-BJILWQEISA-N
SMILES: FC(C=C1NC2=NC(OC3=C(C=C(C=C3C)/C=C/C#N)C)=C4C(COC4)=N2)=C(C=C1)C#N.Cl
Biological Activity: HIV-1 inhibitor-51, a non-nucleoside reverse transcriptase inhibitor (NNRTI), exhibits outstanding antiviral activity against WT HIV-1 (IIIB) and a panel of mutant strains. HIV-1 inhibitor-51 has high binding affinity (KD=2.50 μM) and inhibitory activity (IC50=0.03 μM) to WT HIV-1 RT. HIV-1 inhibitor-51 has EC50s of 2.22-53.3 nM for mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L + V106A, RES056)[1].
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HIV-1 inhibitor-51 | HIV-1 inhibitor-51, a non-nucleoside reverse transcriptase inhibitor (NNRTI), exhibits outstanding antiviral activity against WT HIV-1 (IIIB) and a panel of mutant strains. HIV-1 inhibitor-51 has high binding affinity (KD=2.50 μM) and inhibitory activity (IC50=0.03 μM) to WT HIV-1 RT. HIV-1 inhibitor-51 has EC50s of 2.22-53.3 nM for mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L + V106A, RES056). | |||||||||||||||||||||
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