2. Anti-infection
  3. HIV Reverse Transcriptase
  4. HIV-1 inhibitor-50

HIV-1 invistor-50 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets HIV-1 reverse transcriptase (RT) (IC50=50 nM). HIV-1 inhibitor-50 shows significant antiviral activity, with EC50s of 2.22-53.3nM against HIV-1 IIIB and its mutant strains.

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HIV-1 inhibitor-50 Chemical Structure

HIV-1 inhibitor-50 Chemical Structure

CAS No. : 2834087-69-1

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HIV-1 inhibitor-50 Related Antibodies

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Description

HIV-1 invistor-50 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets HIV-1 reverse transcriptase (RT) (IC50=50 nM). HIV-1 inhibitor-50 shows significant antiviral activity, with EC50s of 2.22-53.3nM against HIV-1 IIIB and its mutant strains[1].

IC50 & Target[1]

HIV-1 (WT)

3.04 nM (EC50)

HIV-1 (L100I)

3.04 nM (EC50)

HIV-1 (K103N)

2.87 nM (EC50)

HIV-1 (Y181C)

10.2 nM (EC50)

HIV-1 (Y188L)

13.2 nM (EC50)

HIV-1 (E138K)

9.77 nM (EC50)

HIV-1 (F227L+V106A)

19.8 nM (EC50)

In Vitro

HIV-1 inhibitor-50 (compound 36a) protects MT-4 cells from HIV-1 IIIB and RES056 with EC50s of 2.22 nM and 53.3 nM, respectively[1].
HIV-1 inhibitor-50 inhibits MT-4 cells viability with an CC50 value of 45.6 μM[1].
HIV-1 inhibitor-50 (hydrochloride; ) shows a lower intrinsic clearance rates in microsomes (CL=87.6 μL/min/mg) and liver (CL=16.6 μL/min/mg), and leads to a higher metabolic stability (T1/2=11.3 min)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HIV-1 inhibitor-50 Related Antibodies

Cell Viability Assay[1]

Cell Line: MT-4 cells
Concentration:
Incubation Time:
Result: Inhibited HIV-1 infection in MT-4 cells with EC50 values of 3.04 nM (L100I), 2.87 nM (K103N), 10.2 nM (Y181C), 13.2 nM (Y188L), 9.77 nM (E138K), 19.8 nM (F227L+V106A), respectively.
In Vivo

HIV-1 inhibitor-50 (compound 36a) (hydrochloride; 2 mg/kg; i.v.; single dose) has a high clearance (CL=103 L/h/kg) and a modest half-life (T1/2=1.43 h)[1].
HIV-1 inhibitor-50 (hydrochloride; 2000 mg/kg; p.o.; single dose) doesn’t result any abnormal behaviors or significant changes in body weight compared with the control in 7 days, indicating no acute toxicity[1].

Pharmacokinetic Analysis[1]

Route Dose (mg/kg) T1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-t (h·ng/mL) AUC0-∞ (h·ng/mL) CL (L/h/kg) F (%)
i.v. 2 1.43 0 484 250 255 103 /
p.o. 10 5.12 0.25 37.5 107 154 / 12.1

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

427.43

Formula

C24H18FN5O2
CAS No.
SMILES

CC1=C(OC2=C3COCC3=NC(NC4=CC(F)=C(C=C4)C#N)=N2)C(C)=CC(/C=C/C#N)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIV-1 inhibitor-50 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-502834087-69-1HIVReverse TranscriptaseHuman immunodeficiency virusInhibitorinhibitorinhibit

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