2. Anti-infection
  3. HBV
  4. HBsAg-IN-1

HBsAg-IN-1 is an orally active, highly liver-selective inhibitor of HBsAg production, with an EC50 of 0.63 nM. HBsAg-IN-1 shows no neurite growth inhibitory activity. HBsAg-IN-1 can be used in studies related to hepatitis B virus (HBV) infection.

For research use only. We do not sell to patients.

HBsAg-IN-1

HBsAg-IN-1 Chemical Structure

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HBsAg-IN-1 Related Antibodies

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Description

HBsAg-IN-1 is an orally active, highly liver-selective inhibitor of HBsAg production, with an EC50 of 0.63 nM. HBsAg-IN-1 shows no neurite growth inhibitory activity. HBsAg-IN-1 can be used in studies related to hepatitis B virus (HBV) infection[1].

In Vitro

HBsAg-IN-1 (Compound (6S,10S)-57) (12.8-40000 nM) potently inhibits HBsAg production in HepG2.2.15 cells, with an EC50 of 0.63 nM, and exhibits extremely low cytotoxicity in these cells (CC50 >200 nM)[1].
HBsAg-IN-1 (12.5-100 μM; 24 h) exhibits negligible cytotoxicity in SH-SY5Y cells, with a CC50 >100 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HBsAg-IN-1 Related Antibodies

ELISA Assay[1]

Cell Line: HepG2.2.15
Concentration: 12.8-40000 nM
Incubation Time: 6 days
Result: Potently inhibited HBsAg production with an EC50 of 0.63 nM.
Exhibited CC50 values >200 nM, indicating negligible cytotoxicity at the tested concentrations.

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y
Concentration: 12.5-100 μM
Incubation Time: 24 h
Result: Showed negligible cytotoxicity, with a CC50 >100 μM (no ≥50% reduction in cell viability at the highest tested concentration of 100 μM).
In Vivo

HBsAg-IN-1 (8-24 mg/kg; p.o.; once daily; for 15 consecutive days) reduces serum HBsAg and HBeAg levels in the AAV-HBV mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, inoculated with AAV vector carrying 1.3-fold overlength genotype D HBV genome, dosing initiated 4 weeks post-inoculation)[1]
Dosage: 8 mg/kg; 24 mg/kg
Administration: p.o.; once daily; 15 days
Result: Reduced serum HBsAg by 0.78 log10 and serum HBeAg by 0.31 log10 relative to predose baseline at day 15 with 8 mg/kg dose.
Reduced serum HBsAg by 0.97 log10 and serum HBeAg by 0.41 log10 relative to predose baseline at day 15 with 24 mg/kg dose.
Caused no significant body weight changes at either dose.
Induced significant reduction in liver weight and liver coefficient in the 24 mg/kg group.
Maintained serum creatinine and ALT levels within normal ranges across both dose groups.
Resulted in lower antigen rebound compared to the RG7834 control group following treatment withdrawal.
Molecular Weight

502.58

Formula

C25H30N2O7S
SMILES

COCC[C@@H]1OC2=C(C=C3C(C[C@@H](C4(C)CCC4)N(C3=CC5=O)C=C5C(O)=O)=C2)N(C1)S(C)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HBsAg-IN-1 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HBsAg-IN-1HBVHepatitis B virusHepG2.2.15 cellshepatitis B virusSH-SY5Y cellsneurite outgrowthAAV-HBV mouse modelHBeAgmicehERG channelshepatitis B surface antigenInhibitorinhibitorinhibit

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