EGFR-IN-95
Based on 1 Customer Validation
EGFR-IN-95 (compound 5j) is an 2,4-diaminonicotinamide derivative. EGFR-IN-95 has potent inhibitory activity against EGFR del19/T790M/C797S and L858R/T790M/C797S.
For research use only. We do not sell to patients.
- Purity: 98.76%
- CAS No.: 3027135-04-9
- Formula: C23H28F2N8O3S
- Molecular Weight:534.58
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
All EGFR Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | GI50 |
1078 nM
Compound: 5j
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Inhibition of cell proliferation of mouse BaF3 cells expressing wild-type EGFR (unknown origin)
Inhibition of cell proliferation of mouse BaF3 cells expressing wild-type EGFR (unknown origin)
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[PMID: 38065292] |
| BaF3 | GI50 |
35 nM
Compound: 5j
|
Inhibition of cell proliferation of mouse BaF3 cells expressing EGFR Del19/T790M/C797S mutant (unknown origin)
Inhibition of cell proliferation of mouse BaF3 cells expressing EGFR Del19/T790M/C797S mutant (unknown origin)
|
[PMID: 38065292] |
| BaF3 | GI50 |
81 nM
Compound: 5j
|
Inhibition of cell proliferation of mouse BaF3 cells expressing EGFR L858R/T790M/C797S mutant (unknown origin)
Inhibition of cell proliferation of mouse BaF3 cells expressing EGFR L858R/T790M/C797S mutant (unknown origin)
|
[PMID: 38065292] |
Chemical Information
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CAS No. 3027135-04-9
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Appearance Solid
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Molecular Weight 534.58
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Formula C23H28F2N8O3S
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Color White to off-white
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SMILES
O=C(C1=C(C=C(N=C1)NC2=CC=NC(C3=CN(N=C3)S(=O)(C4CC4)=O)=N2)N[C@H](CC)C)NCCC(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)