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Plasmodium falciparum histone deacetylase 1

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (636) Cardiovascular Disease (28) Endocrinology (9) Infection (524) Inflammation/Immunology (131) Metabolic Disease (42) Neurological Disease (84)
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Isotope-Labeled Compounds

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Oligonucleotides

GMP Molecules

Pyroxamide 5+ Cited Publications	HDAC Apoptosis	Cancer
Pyroxamide is a potent inhibitor of **histone deacetylase 1 (HDAC1) with an ID₅₀** of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia ^[1].

Hex	Enolase Parasite	Infection Cancer
Hex is an enolase inhibitor and antimalarial agent with K_i values of 74.4 nM and 269.4 nM for ENO2 and ENO1, respectively. Hex is a NfENO and TbENO inhibitor with IC₅₀s value of 0.14 μM and 2.1 μM, respectively. Hex has antimalarial activity against Plasmodium falciparum 3D7, Naegleria fowleri trophozoites and Plasmodium berghei ANKA strain. Hex has anti-tumor effects against intracranial tumors ^[1] .

DHFR-IN-5	Dihydrofolate reductase (DHFR)	Infection
DHFR-IN-5 is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a K_i value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 shows anti-malaria activity ^[1].

KDU691	PI4K Parasite	Infection
KDU691, an imidazopyrazine with potent anti-parasitic activity against blood stage schizonts, gametocytes and liver stages, is a Plasmodium PI4K inhibitor. KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites ^[1].

NKL 22 1 Publications Verification	HDAC	Neurological Disease Cancer
NKL 22 is a potent and selective inhibitor of histone deacetylases (HDAC), with IC₅₀ values of 199 and 69 nM for *HDAC1* and HDAC3, respectively. NKL 22 can reverse abnormal expression of HD‑related genes and restore the levels of key genes including Ppp1r1b in Huntington's disease transgenic mice. NKL 22 can be used for the researches of Huntington's disease and cancer ^[1] .

Ursolic acid acetate Acetylursolic acid; 3-Acetylursolic acid	Parasite HSP	Infection Cancer
Ursolic acid acetate (Acetylursolic acid) is a triterpenoid compound and an inhibitor of Plasmodium falciparum heat shock protein 90 (PfHsp90) with a K_D of 8.16 μM. Ursolic acid acetate is cytotoxic to KB cells, with an IC₅₀ value of 8.4 μM. Ursolic acid acetate can be used in tumor and antimalarial research ^[1] .

LIN28 inhibitor LI71	MicroRNA Parasite	Infection Cancer
LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC₅₀: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC₅₀: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum ^[1] .

Histone Acetyltransferase Inhibitor II 1 Publications Verification	Histone Acetyltransferase	Cancer
Histone Acetyltransferase Inhibitor II (compound 2c) is a potent, selective and cell permeable *p300 histone* acetyltransferase inhibitor, with an IC₅₀** of 5 µM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells ^[1].

Droxinostat 3 Publications Verification NS 41080	HDAC Apoptosis	Cancer
Droxinostat (NS 41080) is a histone deacetylase (HDAC) inhibitor. Droxinostat selectively inhibits HDAC3, HDAC6, and HDAC8 with IC₅₀ values of 16.9 μM, 2.47 μM, and 1.46 μM, respectively. Droxinostat can be used for the research of hepatocellular carcinoma (HCC) ^[1] .

GLUT1-IN-2	GLUT	Infection
GLUT1-IN-2 (compound 17) is a *GLUT1* inhibitor with an IC₅₀ value of 12 μM. GLUT1-IN-2 shows inhibitory effect to Plasmodium falciparum hexose transporter PfHT with an IC₅₀ value of 13 μM. GLUT1-IN-2 can be used for the research of infection ^[1].

Norcaesalpinin E	Parasite	Infection
Norcaesalpinin E, a C-17-norcassane-type diterpene found in Caesalpinia crista, is a **Plasmodium falciparum growth inhibitor with an IC₅₀** of 90 nM. Norcaesalpinin E induces dose-dependent growth inhibition of Plasmodium falciparum. Norcaesalpinin E can be used for the research of malaria ^[1] .

RSC133	DNA Methyltransferase HDAC MDM-2/p53	Others Inflammation/Immunology
RSC133 is a dual inhibitor of DNA methyltransferase 1 and **histone deacetylase 1** inhibitor. RSC133 promotes cell proliferation, up-regulates H₃K₉ histone acetylation, down-regulates p53, p21, p16/INK4A, and ablates pro-senescence phenotypes ^[1] .

SHMT-IN-1	SHMT	Infection
SHMT-IN-1 is a Plasmodium falciparum Serine Hydroxymethyltransferase (PfSHMT) inhibitor with an IC₅₀ of 350 nM. SHMT-IN-1 can be used for the research of malaria ^[1].

Cheilanthifoline	Parasite	Infection
Cheilanthifoline, an alkaloid, is isolated from Corydalis calliantha. Cheilanthifoline exhibits antiplasmodial activities against Plasmodium falciparum, with IC₅₀s of 0.90 μg/mL and 1.22 μg/mL for wild type (TM4) and multidrug resistant (K1) strains, respectively ^[1].

CK-2-68 1 Publications Verification	Parasite	Infection
CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase (NDH2) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC₅₀ of 40 nM ^[1].

Histone H3 (1-34)	Histone Methyltransferase	Others
Histone H3 (1-34) is a peptide derived from human histone isotype 3.1. Histones are the main protein components of eukaryotic chromatin. Histone variants and histone modifications modulate chromatin structure, ensuring the precise operation of cellular processes associated with genomic DNA ^[1] .

PfDHODH-IN-1	Parasite Lactate Dehydrogenase DNA/RNA Synthesis	Infection
PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity ^[1] .

CM-1758	HDAC	Cancer
CM-1758 is a histone deacetylase (HDAC) inhibitor. CM-1758 inhibits tumor growth in vivo. CM-1758 induces acetylation of non-histone proteins in acute myeloid leukemia cells ^[1].

C3361	Parasite	Infection
C3361 is a moderate specific Plasmodium falciparum hexose transporter 1 (PfHT1) and Plasmodium berghei hexose transporter 1 (PbHT1) inhibitor with K_i values of 8.6 and 9.4 μM. C3361 inhibits TgGT1 with a K_i of 82 μM. C3361 attenuates hepatic (IC₅₀ = 15 μM) and ookinete development of P. berghei. C3361 can suppress the growth of blood-stage parasites. C3361 can be used for the research of infection, such as malaria ^[1] .

13,21-Dihydroeurycomanone	Parasite	Infection
13,21-Dihydroeurycomanone, a natural compound isolated from Eurycoma longifolia root, possesses anti-parasite activity for Plasmodium falciparum and Toxoplasma gondii ^[1] .

DHODH-IN-4	Parasite Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection Inflammation/Immunology
DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC₅₀ values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity ^[1].

TDI-8304	Parasite	Infection
TDI-8304, a macrocyclic peptide, is a potent, species selective, and noncovalent Plasmodium falciparum (Pf20S) inhibitor. TDI-8304 shows highly selective for Pf20S over human proteasomes ^[1].

Digitolutein	Parasite	Infection
Digitolutein is a natural product that can be isolated from the stem bark and the roots of Morinda lucida Benth. Digitolutein effectively inhibits the growth of **Plasmodium falciparum with an IC₅₀** value of 12.92 μg/mL. Digitolutein can be used for the research of infection ^[1].

Tefinostat 1 Publications Verification CHR-2845	HDAC Apoptosis	Cancer
Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias ^[1].

Nitidanin (±)-Nitidanin	Parasite HCV	Infection
Nitidanin ((±)-Nitidanin) is an antimalarial and antiviral compound that can be isolated from the wood of Xanthoxylum nitidun D. C. Nitidanin is shows IC₅₀ values of 21.2 and 18.4 μM for D6 and W2 clones of Plasmodium falciparum, respectively. Nitidanin can be used for the research of malaria and virus infection ^[1] .

Aristolactam A II Aristololactam A II	Parasite COX	Infection
Aristolactam A II (Aristololactam A II) is a weak COX inhibitor with cytotoxic and anti-plasmodial activities. Aristolactam A II exhibits inhibitory activity against Chloroquine (HY-17589A)-sensitive strains, and exerts its inhibitory effect on Plasmodium falciparum growth by inducing cell membrane damage marked by LDH release. Aristolactam A II can be applied to the research of malaria-related mechanisms ^[1] .

Antimalarial agent 58	Parasite	Infection
Antimalarial agent 58 is a diaminoquinoline methanol compound with weak in vitro activity against Plasmodium falciparum strain D6, and no activity against Plasmodium falciparum strains W2, C235 and C2A ^[1].

Gamhepathiopine	Parasite Mitochondrial Metabolism	Infection
Gamhepathiopine is a thienopyrimidinone compound. Gamhepathiopine exerts antimalarial effects by targeting the Q_o site of Plasmodium falciparum cytochrome b and inhibiting the activity of complex III in the electron transport chain ^[1].

MMV1557817	Parasite	Infection
MMV1557817 is an orally active and potent antimalarial compound. MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 and M17, leading to inhibition of end-stage hemoglobin digestion in asexual parasites ^[1].

PI4Kβ-IN-1	PI4K Parasite	Infection
PI4Kβ-IN-1 is an orally active and selective PI4Kβ inhibitor, with an IC₅₀ of 0.9 nM. PI4Kβ-IN-1 exhibits inhibitory activity against all stages of the P. falciparum life cycle, including blood, liver, and transmission stages. PI4Kβ-IN-1 demonstrates potent antimalarial efficacy in the mouse model infected with Plasmodium falciparum. PI4Kβ-IN-1 can be used for the study of malaria caused by Plasmodium falciparum ^[1].

DNMT-IN-3	Parasite DNA Methyltransferase	Others
DNMT-IN-3 is an DNA Methyltransferase (DNMT) inhibitor, and plays an antimalarial role with IC₅₀ of 60 nM against Plasmodium falciparum (Plasmodium). DNMT-IN-3 can be used for malaria related research ^[1].

HDAC6-IN-66	HDAC	Cancer
HDAC6-IN-66 is a potent and selective **histone deacetylase (HDAC) 6 inhibitor with an IC₅₀** of 1.8 nM. HDAC6-IN-66 induces α-tubulin acetylation over histone H3. HDAC6-IN-66 can be used for the research of cancer ^[1].

2,2-Diethoxyethanol	Drug Intermediate	Infection
2,2-Diethoxyethanol is a drug intermediate used in research related to Plasmodium falciparum infection ^[1].

Atherosperminine Atherospermine	Parasite Phosphodiesterase (PDE)	Infection
Atherosperminine (Atherospermine) is a phosphodiesterase inhibitor. Atherosperminine inhibits growth of chloroquine-resistant Plasmodium falciparum. Atherosperminine scavenges DPPH free radicals, exhibits ferric reducing power, and chelates metal ions. Atherosperminine can be used for the research of malaria ^[1] .

DHODH-IN-8	Parasite Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection
DHODH-IN-8 (Compound 27) is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC₅₀s of 0.13 μM and 47.4 μM, and K_is of 0.016 μM and 5.6 μM, respectively. DHODH-IN-8 has antimalarial activity ^[1].

Tuberostemonine (Standard)	Reference Standards Parasite	Infection
Tuberostemonine (Standard) is the analytical standard of Tuberostemonine. This product is intended for research and analytical applications. Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity Ferredoxin-NADP ⁺ reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine has a level of activity as a feeding deterrent ^[1] .

PTG-0861	HDAC Apoptosis	Cancer
PTG-0861 is a selective histone deacetylase 6 (HDAC6) inhibitor with the IC₅₀ value of 5.92 nM. PTG-0861 induces apoptosis and can be used in the study of acute myeloid leukemia, multiple myeloma and other hematological cancers ^[1].

*Anti-Histone* H3 Antibody**	Histone Methyltransferase	Inflammation/Immunology
The Anti-Histone H3 Antibody is a CHO-expressed humanized antibody that targets Histone H3. The Anti-Histone H3 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-Histone H3 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

MMV006833 M-833	Parasite	Infection
MMV006833 is an inhibitor for Plasmodium falciparum. MMV006833 targets the lipid-transfer protein *PfSTART1* and inhibits the development of Plasmodium falciparum at the ring stage ^[1].

Dabequin phosphate	Parasite	Infection
Dabequin phosphate is an antimalarial agent, that exhibits inhibitory activity against Plasmodium falciparum ^[1].

SPB07935	Parasite	Infection
SPB07935 inhibits the plasmepsin II in Plasmodium falciparum and can be used as an antimalarial agent. SPB07935 regulates the life cycle of P. falciparum, inhibits the growth of Plasmodium strains FcB1 and 3D7 with IC₅₀ of 8 μM and 4.7 μM ^[1].

Antimalarial agent 42	Parasite	Infection
Antimalarial agent 42 (Compound 2) is an antimalarial agent, that inhibits Plasmodium falciparum in the phase of asexual blood stages (IC₅₀ <0.5μM) and gametocytes (IC₅₀ is 0.14 μM) ^[1].

MC4343	HDAC	Cancer
MC4343 is a potent and dual inhibitor of EZH2 and **histone deacetylase**. MC4343 has the potential for the research of cancer disease.

8304-vs	Parasite Proteasome	Infection
8304-vs is a macrocyclic anti-Plasmodial agent that covalently and irreversibly targets the Plasmodium proteasome. 8304-vs effectively inhibits the growth of Plasmodium falciparum ^[1].

MMV1634566	Parasite	Infection Cancer
MMV1634566 is a potent antimalarial agent. MMV1634566 inhibits Plasmodium falciparum. MMV1634566 shows cytotoxicity ^[1].

PfThrRS-IN-1	Parasite	Infection
PfThrRS-IN-1 (compound 11) is a potent inhibitor of Plasmodium falciparum threonyl tRNA synthetase (PfThrRS), with the IC₅₀ value of 0.1 μM. PfThrRS-IN-1 is a potent antimalaria agent ^[1].

Cat. No.	Product Name

HY-L024

Histone Modification Research Compound Library

919 compounds

A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases.

MCE owns a unique collection of 919 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening.

HY-L005M

Epigenetics Compound Library Mini

297 compounds

Epigenetics involves heritable phenotypic changes that occur without alterations to the underlying DNA sequence. Key mechanisms include DNA methylation, histone modifications, and regulation by small non-coding RNAs such as microRNAs. By modifying DNA, histones, or RNA—while leaving their primary sequences intact—these processes influence molecular function and regulation, thereby playing critical roles in cellular differentiation, embryonic development, gene expression control, aging, and diseases such as cancer.

MCE provide a unique collection of 297 epigenetics-related compounds. For each regulatory target and its subtype, 3 to 5 highly specific representative compounds have been retained, which can be used in epigenetic and related disease research.

HY-L005

Epigenetics Compound Library

1,970 compounds

Epigenetics refers to changes in phenotype that are not rooted in DNA sequence. Many types of epigenetic processes have been identified, including DNA methylation, alteration in the structure of histone proteins and gene regulation by small noncoding microRNAs. Modification of DNA, protein, or RNA, resulting in changes to the function and/or regulation of these molecules, without altering their primary sequences, reveals the complexities of cellular differentiation, embryology, the regulation of gene expression, aging, cancer, and other diseases.

MCE provide a unique collection of 1,970 epigenetics-related compounds that can be used in the research of the related diseases.

HY-L203

Methylation Compound Library

342 compounds

Methylation is an epigenetic modification mechanism that involves adding methyl groups to molecules such as DNA and histones, which can alter gene expression without changing the DNA sequence. This process is catalyzed by enzymes such as DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs), and can be reversed by demethylases. The balance of methylation and demethylation is crucial for maintaining cellular function and genomic stability. Abnormal regulation of methylation may lead to a variety of diseases, including cancer, neurological disorders, and developmental abnormalities. A deep understanding of the molecular mechanisms of methylation metabolism is essential for developing therapeutic strategies for diseases associated with methylation dysregulation.

MCE contains 342 compounds targeting methylation/demethylation enzymes, which is of significant value for studying the pathways of methylation metabolism and exploring their mechanisms of action in diseases.

HY-L082

Antiparasitic Compound library

649 compounds

A parasite is an organism that lives on or in a host organism and gets its food from or at the expense of its host. Parasites of humans include protozoans, helminths, and ecto-parasites (organisms that live on the external surface of a host). They are responsible for many diseases and are transmitted to their hosts most often through the ingestion of contaminated food, water or through the bite of an arthropod (e.g., a fly or tick), which can act as an intermediate host and as a vector. Parasitic diseases of humans are a major global health problem causing significant morbidity and mortality, especially in developing countries. Each year there are hundreds of millions of people infected with disease-causing parasites, particularly in tropical and subtropical regions of the world, resulting in an estimated one million deaths. Therefore, there is a dire need of novel anti-parasitic drugs.

MCE has a unique collection of 649 compounds with validated anti-parasitic activity which offer researchers an opportunity to screen novel anti-parasitic targets.

HY-L249

Lactylation Compound Library

5,946 compounds

Protein lactylation, an emerging post-translational modification identified in recent years, plays a critical role in linking cellular metabolic reprogramming, epigenetic regulation, and signaling networks. Based on a systematic framework encompassing lactate metabolism, lactylation, and downstream signaling pathways, this compound library comprehensively targets multiple regulatory layers, including histone modification enzymes (such as p300 and HDACs), key glycolytic enzymes (such as PKM2, LDHA, and GAPDH), transcriptional regulators (such as STAT3, HMGB1, and p53), as well as central signaling pathway nodes including HIF-1α, NF-κB, and PI3K-AKT-mTOR. This integrated design enables a comprehensive representation of the regulatory roles of lactylation across the “metabolism–epigenetics–signaling” axis.

MCE has assembled a collection of 5,946 known bioactive compounds and potential functional molecules, making this library suitable for a wide range of applications, including high-throughput drug screening, inhibitor identification, and mechanistic studies. It can be used to systematically evaluate the functional roles of lactylation in biological processes such as tumor metabolism, immune regulation, and inflammatory responses, and to efficiently identify small-molecule candidates with regulatory potential, thereby facilitating the development of innovative therapeutics targeting the interplay between metabolism and epigenetic regulation.

Cat. No.	Product Name	Type

HY-143218

TPE-MI

10+ Cited Publications

Tetraphenylethene maleimide

Fluorescent Dyes

TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasites Plasmodium falciparum ^[1] .

HY-D0914

Fast Green FCF

FD&C Green No. 3; Food green 3; C.I. 42053

Fluorescent Dyes

Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF inhibits α-synuclein aggregation, as well as Aβ and P2X4 receptor, and TLR4/Myd88/NF-κB. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function ^[1] .

HY-145746

Sulfo-Cy5 azide

Fluorescent Dyes

Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. Sulfo-Cy5 azide enables fluorescence imaging, tissue and cellular visualization of PD-L1 in tumors, and site-specific modification of anti-PD-L1 antibodies. Sulfo-Cy5 azide has been employed for RNA labeling and imaging. Sulfo-Cy5 azide can be conjugated to targeting agents for fluorescence imaging in atherosclerosis and breast cancer models (Ex/Em = 645/670 nm) ^[1] .

HY-136248

Cyanine 3 Tyramide 1 Publications Verification Tyramide-Cy3	Fluorescent Dyes
Cyanine 3 Tyramide (Tyramide-Cy3) is an orange fluorescent dye used as a reporter fluorescent substrate for horseradish peroxidase (HRP)-catalyzed deposition, which serves as a signal amplification technique in immunoassays and in situ nucleic acid hybridization ^[1].

HY-D1991

ATTO 647

Fluorescent Dyes

ATTO 647 is a carborhodamine fluorophore and imaging tracer with photostable properties. ATTO 647 serves as a fluorescent probe to investigate cell membrane structure and diffusion characteristics. When conjugated with wheat germ agglutinin, ATTO 647 specifically binds to N-acetyl-β-D-glucosamine and sialic acid residues on membrane glycoproteins, enabling single-molecule tracing of glycoprotein diffusion. ATTO 647 exhibits highly stable fluorescence properties with significantly reduced blinking in mounting media such as ROXS (AA/MV) and ROXS (TX/TQ), whereas its brightness properties vary in Ibidi-MM and Vectashield. ATTO 647 can also be used to label histone H2B-GFP in fixed cells for confocal microscopy photobleaching experiments ^[1] .

HY-13506G

M344 (GMP) D 237 (GMP); MS 344 (GMP)	Fluorescent Dyes
M344 (GMP) (D 237) (GMP) is the GMP level of M344 (HY-13506). GMP level of small molecules can be used as auxiliary reagents in cell therapy. M344 is a kind of histone acetylation enzyme inhibitor ^[1].

HY-DY1024

TPE-MI (solution)

Fluorescent Dyes

TPE-MI (Tetraphenylethene maleimide) (solution) is a thiol probe for measuring unfolded protein load and proteostasis in cells (the excitation wavelength is 350 nm and the emission wavelength is 470 nm). TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum ^[1] .
Solvent and concentration: DMSO: 10 mM

HY-15149G

Romidepsin

FK 228; FR 901228; NSC 630176

Fluorescent Dyes

Romidepsin (GMP) (FK 228 (GMP)) is Romidepsin (HY-15149) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC₅₀s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively ^[1]. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis .

HY-158738

TCEP-biotin Tris(2-carboxyethyl)phosphine-biotin	Fluorescent Dyes
TCEP-biotin is biotinylated TCEP (HY-W011500). TCEP-biotin is also a probe for histone lysine crotonylation ^[1].

HY-12186G

3-Deazaneplanocin A hydrochloride DZNep hydrochloride; NSC 617989 hydrochloride; 3-Deazaneplanocin hydrochloride	Fluorescent Dyes
3-Deazaneplanocin A (DZNep) hydrochloride (GMP) is 3-Deazaneplanocin A hydrochloride (HY-12186) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor ^[1] .

HY-D2280

Estrogen receptor β/HDAC probe 1	Fluorescent Dyes
Estrogen receptor β/HDAC probe 1 (compound P1) is a near-infrared fluorescent probe that dual-targets the estrogen receptor (Estrogen Receptor/ERR) β/histone deacetylase HDAC ^[1].

HY-D0914A

Fast green FCF free acid

Fluorescent Dyes

Fast green FCF free acid is a dye that is acid-resistant. Fast Green FCF free acid inhibits α-synuclein aggregation, as well as Aβ, P2X4 receptor and TLR4/Myd88/NF-κB. Fast Green FCF free acid is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF free acid improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function ^[1] .

HY-P11724

Histone H4 peptide substrate (1-21)	Fluorescent Dyes

HY-W713888

Aniline blue diammonium

Fluorescent Dyes

Aniline blue diammonium is a component of commonly used polychrome stains. Aniline blue diammonium is used to stain collagen fibers in tissue sections using Masson′s trichrome protocol for staining multiple components. Collagen is stained blue by this method. The dye is suitable for selective staining of callose in plant specimens and staining histones for assessing nuclear maturity. Aniline blue diammonium is used in Gomori′s one-step trichrome stain and Mallory′s connective tissue stain for tissue including kidney and intestine.

HY-13689G

Go 6983

Fluorescent Dyes

Go 6983 GMP is Go 6983 (HY-13689) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Go 6983 is a dual inhibitor targeting Suv39h1/2 (KMT1A/KMT1B) and PKC, as well as a transcriptional activator capable of inducing DNA hypomethylation. Go 6983 stimulates the transcription of Prdm14 by reducing Suv39h1/2 protein levels, decreasing histone modifications in the Prdm14 promoter region, and increasing the recruitment of RNA polymerase II. Go 6983 induces genome-wide DNA hypomethylation by inhibiting de novo methyltransferase expression and increasing Tet1/Tet2 levels, thereby promoting self-renewal and pluripotency maintenance of stem cells. Meanwhile, Go 6983 can block PKC-mediated signaling pathways to reduce the expression of EMT-related genes and eliminate the upregulation of antioxidant genes downstream of NRF2. Go 6983 is mainly used in mechanism studies related to myocardial ischemia/reperfusion injury ^[1] .

Cat. No.	Product Name	Type

HY-109521A

Manganese chloride tetrahydrate, molecular biology grade,≥99.0% (KT)

Manganese(Ⅱ) chloride tetrahydrate, molecular biology grade,≥99.0% (KT)

Biochemical Assay Reagents

Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT) is an orally active and a blood-brain barrier penetrant compound. It affects the activities of multiple enzymes in cells, such as regulating the activities of histone acetyltransferase (HAT) and histone deacetylase (HDAC), thereby affecting gene expression. It has multiple activities such as neurotoxicity, embryotoxicity, and reproductive toxicity. It is currently mainly used in neurodegenerative diseases and toxicology research.

HY-NP155

Histone (calf thymus) 1 Publications Verification	Biochemical Assay Reagents
Histone (calf thymus) is a histone found in the deoxyribonucleoprotein of calf thymus and can be obtained by acid extraction technique ^[1].

HY-Y1325I

Sodium acetate trihydrate, 99.5%

Biochemical Assay Reagents

Sodium acetate trihydrate, 99.5% is a short-chain fatty acid salt with multiple biological activities. Sodium acetate trihydrate, 99.5% serves as a direct precursor of acetyl-CoA, and it extensively affects gene expression by promoting histone acetylation. Sodium acetate trihydrate, 99.5% can activate the p38 MAPK pathway to induce cancer cell apoptosis. Sodium acetate trihydrate, 99.5% can activate the Wnt/β-catenin signaling pathway to stimulate the proliferation and migration of cecal epithelial cells, thereby improving intestinal health. Sodium acetate trihydrate, 99.5% alleviates lead accumulation and oxidative damage by upregulating the testosterone-dependent eNOS/NO/cGMP signaling pathway, as well as activating the Nrf2/HO-1 pathway and its downstream antioxidant enzymes ^[1] .

HY-15435A

CHAPS hydrate

4 Publications Verification

Biochemical Assay Reagents

CHAPS hydrate is a cholic acid-derived, sulfobetaine-type zwitterionic detergent and micelle-forming agent. CHAPS hydrate exhibits properties of weak cationic or nonionic surfactants in different solution systems, undergoes micellization, and forms small, loose hydrophilic aggregates that are temperature-dependent. CHAPS hydrate stabilizes mononucleosomes under different ionic strengths, reduces nucleosome sequence specificity, promotes sliding of histone cores along DNA, solubilizes Tamm‑Horsfall protein to reduce its interference with urinary exosome isolation, and maintains vesicle structure and the activity of related proteins at the same time. CHAPS hydrate is used to recover native folded fusion proteins, enhance the binding capacity of GST fusion proteins, and restore GST enzyme activity. However, CHAPS hydrate cannot refold proteins denatured by urea, guanidine hydrochloride or heat, nor can it construct the structure of intrinsically disordered proteins. CHAPS hydrate is commonly used in research on the separation and purification of membrane proteins ^[1] .

HY-134421

2-Butenoyl coenzyme A lithium

Biochemical Assay Reagents

2-Butenoyl coenzyme A lithium is an inactivator and a substrate of Plasmodium falciparum enoyl-β-hydroxyacyl-acyl carrier protein (ACP) reductase and other enoyl-CoA reductases, and it is also the lithium salt of trans-2-methyl-2-butenoyl coenzyme A. 2-Butenoyl coenzyme A lithium acts on short-chain and medium-chain coenzyme A dehydrogenases as well as glutaryl-CoA dehydrogenase, and shows no activity against wild-type isovaleryl-CoA dehydrogenase. 2-Butenoyl coenzyme A lithium functions as a metabolite in the L-isoleucine catabolic pathway, and can serve as a substrate in the activity assay of 3-ketothiolase. 2-Butenoyl coenzyme A lithium is applicable to research related to 3-ketothiolase deficiency ^[1] .

HY-Y0319B1

Potassium acetate, for molecular biology 1 Publications Verification	Biochemical Assay Reagents
Potassium acetate, for molecular biology is an acetate salt commonly used as a deicing agent, food preservative and potassium source. Potassium acetate, for molecular biology can serve as an activator for preparing waste tea-based activated carbon, and is applied to the adsorption of Acid Blue 25 dye ^[1] .

HY-40190

5-Bromo-2,3-dihydro-1H-inden-1-one	Biochemical Assay Reagents
5-Bromo-2,3-dihydro-1H-inden-1-one is an important indanone intermediate that is widely used in the synthesis of anti-tumor indanone derivatives ^[1] .

HY-W001240

2-Fluorophenylboronic acid	Biochemical Assay Reagents
2-Fluorophenylboronic acid is a compound intermediate. 2-Fluorophenylboronic acid functionalizes IPG. 2-Fluorophenylboronic acid can be used to synthesize compounds with ABS activity. 2-Fluorophenylboronic acid can be used in P. falciparum infection studies ^[1] .

HY-W034869

Reinecke Diamino-tetraisothiocyanato-chromium	Biochemical Assay Reagents
Reinecke (Diamino-tetraisothiocyanato-chromium) is an ammonium salt. Reinecke participates in the quantitative precipitation of histones and basic compounds present in acidic tissue extracts by forming Reinecke complexes ^[1].

HY-13506G

M344 (GMP) D 237 (GMP); MS 344 (GMP)	Biochemical Assay Reagents
M344 (GMP) (D 237) (GMP) is the GMP level of M344 (HY-13506). GMP level of small molecules can be used as auxiliary reagents in cell therapy. M344 is a kind of histone acetylation enzyme inhibitor ^[1].

HY-NP155A

Histone H1 (calf thymus)	Biochemical Assay Reagents
Histone H1 (calf thymus) is a linker histone subtype found in the deoxyribonucleoprotein of calf thymus and can be obtained by separation and purification from total calf thymus histones ^[1].

HY-15149G

Romidepsin

FK 228; FR 901228; NSC 630176

Biochemical Assay Reagents

HY-12186G

3-Deazaneplanocin A hydrochloride DZNep hydrochloride; NSC 617989 hydrochloride; 3-Deazaneplanocin hydrochloride	Biochemical Assay Reagents
3-Deazaneplanocin A (DZNep) hydrochloride (GMP) is 3-Deazaneplanocin A hydrochloride (HY-12186) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor ^[1] .

HY-E70176

*N-Deacetylase/N-Sulfotransferase 1* EC:2.8.2.8; NDST1	Biochemical Assay Reagents
N-Deacetylase/N-Sulfotransferase 1 is a sulfotransferase. N-Deacetylase/N-Sulfotransferase 1 modifies heparan sulfate-dependent growth factor and morphogen signalling ^[1].

HY-E70177

*N-Deacetylase/N-Sulfotransferase 2* EC:2.8.2.8; NDST2; N-HSST 2	Biochemical Assay Reagents
N-Deacetylase/N-Sulfotransferase 2 is a sulfotransferase. N-Deacetylase/N-Sulfotransferase 2 synthesizes serglycin-bound heparin chains in mast cells ^[1].

HY-131455A

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA

Biochemical Assay Reagents

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA is used for detection of modification site for N-myristoylated and GPI-anchored proteins in blood-stage P. falciparum ^[1]. Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 (TFA) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-13689G

Go 6983

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P2161B

TAK-683 acetate 4 Publications Verification	Kisspeptin Receptor	Cancer
TAK-683 acetate is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 acetate is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively ^[1]. TAK-683 acetate depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer ^[1] .

HY-P5285

Lunasin	Parasite	Infection Inflammation/Immunology Cancer
Lunasin is a bioactive peptide with antioxidant, anti-inflammatory, anticancer and anti-aging properties. Lunasin can be isolated from soybean. Lunasin also has an epigenetic mechanism of action associated with histone acetylation. Lunasin can be internalized into cells and inhibit Oncosphere formation in cancer cells ^[1].

HY-P1958

Histone H4 (2-21)	HSV	Infection
Histone H4 (2-21) is the core histones associated with chromatinization of herpes simplex virus 1 (HSV-1) genomes ^[1].

HY-P5544

M-TriDAP N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid	NOD-like Receptor (NLR)	Others
M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a *NOD1/2* agoist and biological active peptide ^[1].

HY-P2258

Histone H3 (1-34)	Histone Methyltransferase	Others
Histone H3 (1-34) is a peptide derived from human histone isotype 3.1. Histones are the main protein components of eukaryotic chromatin. Histone variants and histone modifications modulate chromatin structure, ensuring the precise operation of cellular processes associated with genomic DNA ^[1] .

HY-P2465A

Histone H3 (1-35) TFA	DNA/RNA Synthesis	Cancer
Histone H3 (1-35) TFA is a 35-residue peptide of histone H3. Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells ^[1].

HY-P2254

H3K27(Me3) (15-34)	Histone Methyltransferase	Cancer
H3K27(Me3) (15-34), a histone peptide, is a repressive chromatin mark derived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me) ^[1] .

HY-P1597

Malantide 1 Publications Verification	PKA PKC	Cancer
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a K_m of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts ^[1]. Malantide is also an efficient substrate for PKC with a K_m of 16 μM .

HY-P10948A

CS-VIP 8 hydrochloride	WDR5 Histone Methyltransferase	Cardiovascular Disease
CS-VIP 8 hydrochloride is a selective allosteric WDR5 protein inhibitor (K_i= 0.008 μM). CS-VIP 8 hydrochloride induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 hydrochloride is promising for research of hematological diseases such as leukemia ^[1].

HY-19554

MM-401	WDR5 Apoptosis	Cancer
MM-401 is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC₅₀ = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia ^[1].

HY-P2552

Histone H3 (1-21)	Peptides	Others
Histone H3 (1-21), derived from Histone H3 1-21 amino acids, is usually used as a substrate for methyltransferase (Histone 3 K4 and K9) and acetyltransferase (Histone 3 K9 and K14) assays ^[1].

HY-P2480

Histone H1-derived Peptide	CDK	Others
Histone H1-derived Peptide is a phosphopeptide and the peptide substrates containes a sequence in accordance with the optimal recognition motif for CDK, can be used to detecting CDK1-cyclinB1 enzyme activity ^[1] .

HY-P5087

Histone H3 (1-20)	Peptides	Others
Histone H3 (1-20) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development ^[1].

HY-P2256

H3K4(Me2) (1-20) 1 Publications Verification	Peptides	Others
H3K4(Me2) (1-20) is a histone peptide. H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage ^[1] .

HY-P10463

ssK36	Histone Methyltransferase	Cancer
ssK36 is a supersubstrate peptide of the histone methyltransferase (SET) domain protein 2 (SETD2), and ssK36 is designed for the SETD2 protein, a specific PKMT. ssK36 is responsible in human cells for adding methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. ssK36 can be methylated by SETD2 at a rate more than 100 times faster than the natural substrate H3K36. ssK36 can be used to study the catalytic mechanism of PKMTs, especially substrate specificity and catalytic efficiency ^[1].

HY-P4634

*(Lys(Me)327)-Histone* H3 (21-44)-Gly-Lys(biotinyl)**	Peptides	Others
(Lys(Me)327)-Histone H3 (21-44)-Gly-Lys(biotinyl) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development ^[1].

HY-P2161

TAK-683	Kisspeptin Receptor	Cancer
TAK-683 is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively ^[1]. TAK-683 depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer ^[1] .

HY-P5115

*(Lys(Me,Me)27)-Histone* H3 (21-44)-Gly-Lys(Biotinyl)**	Peptides	Others
(Lys(Me,Me)27)-Histone H3 (21-44)-Gly-Lys(Biotinyl) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development ^[1].

HY-P4636

*(Lys(Me)34)-Histone* H3 (1-21)-Gly-Gly-Lys(biotinyl) amide**	Peptides	Others
(Lys(Me)34)-Histone H3 (1-21)-Gly-Gly-Lys(biotinyl) amide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development ^[1].

HY-P4614

*(Lys(Ac)5,8,12,16)-Histone* H4 (1-25)-Gly-Ser-Gly-Ser-Lys(biotinyl)**	Peptides	Others
(Lys(Ac)5,8,12,16)-Histone H4 (1-25)-Gly-Ser-Gly-Ser-Lys(biotinyl) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development ^[1].

HY-P2255

H3K4(Me) (1-20)	Histone Demethylase	Others
H3K4(Me) (1-20), a histone peptide. H3K4me is an intricately regulated posttranslational modification, which is broadly associated with enhancers and promoters of actively transcribed genomic loci ^[1].

HY-P5113A

Histone H3 (1-21)-Gly-Gly-Lys(biotinyl) amide TFA	Peptides	Others
Histone H3 (1-21)-Gly-Gly-Lys(biotinyl) amide TFA is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development ^[1].

HY-P0324

Parasin I	Bacterial	Infection
Parasin I is a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, and shows antimicrobial activity.

HY-P10463A

ssK36 TFA	Histone Methyltransferase	Cancer
ssK36 TFA is a supersubstrate peptide of the histone methyltransferase (SET) domain protein 2 (SETD2) , and ssK36 TFA is designed for the SETD2 protein, a specific PKMT. ssK36 TFA is responsible in human cells for adding methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. ssK36 TFA can be methylated by SETD2 at a rate more than 100 times faster than the natural substrate H3K36. ssK36 TFA can be used to study the catalytic mechanism of PKMTs, especially substrate specificity and catalytic efficiency ^[1].

HY-P10948

CS-VIP 8	WDR5 Histone Methyltransferase	Cardiovascular Disease
CS-VIP 8 is a selective allosteric WDR5 protein inhibitor (K_i= 0.008 μM). CS-VIP 8 induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 is promising for research of hematological diseases such as leukemia ^[1].

HY-P2228

Chlamydocin (purity≥70%)	HDAC Apoptosis	Cancer
Chlamydocin (purity≥70%), a fungal metabolite, is a highly potent HDAC inhibitor, with an IC₅₀ of 1.3 nM. Chlamydocin (purity≥70%) exhibits potent antiproliferative and anticancer activities. Chlamydocin (purity≥70%) induces apoptosis by activating caspase-3 ^[1].

HY-P2465

Histone H3 (1-35)	DNA/RNA Synthesis	Cancer
Histone H3 (1-35) is a 35-residue peptide of histone H3. Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells ^[1].

HY-P2554

Histone H3 (1-25), amide	Peptides	Others
Histone H3 (1-25), amide is an N-terminal peptide fragment of histone H3. Histone H3 (1-25), amide can be used to identify the substrate for histone methyltransferases (HMTs). Histone H3 (1-25), amide, as a substrate for HMT G9a, shows more efficient than histone H3 (15-39) and full-length histone H3 ^[1].

HY-P3931

Histone H2b(29-35)	Peptides	Others
Histone H2b(29-35) is a synthetic heptapeptide that used as a substrate for cGMP-dependant kinase ^[1].

HY-P2257

H3K4(Me3) (1-20)	Histone Demethylase	Others
H3K4(Me3) (1-20) is a histone peptide. Trimethylation of histone H3 on lysine 4 (H3K4 me3) is found in active euchromatin but not in silent heterochromatin ^[1] .

HY-W010835

Boc-D-Cys(Trt)-OH Boc-S-trityl-D-cysteine	Amino Acid Derivatives	Others
Boc-D-Cys(Trt)-OH (Boc-S-trityl-D-cysteine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize the bicyclic depsipeptide histone deacetylase inhibitor spirocysteine ^[1].

HY-P4627

*(Lys(Me)29)-Histone* H3 (1-21)-Gly-Gly-Lys(biotinyl)**	Peptides	Others
(Lys(Me)29)-Histone H3 (1-21)-Gly-Gly-Lys(biotinyl) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development ^[1].

HY-P5113

Histone H3 (1-21)-Gly-Gly-Lys(biotinyl) amide	Peptides	Others
Histone H3 (1-21)-Gly-Gly-Lys(biotinyl) amide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development ^[1].

HY-P2115

Ramorelix	GnRH Receptor	Cancer
Ramorelix is a luteinizing-hormone-releasing hormone (LHRH) antagonist. Ramorelix can inhibit tumor progression in vivo. Ramorelix can be studied in anti-cancer research ^[1].

HY-P5988

N-myristoyl-RKRTLRRL	PKC	Cancer
N-myristoyl-RKRTLRRL inhibits binding of PKC substrates. N-myristoyl-RKRTLRRL inhibits Ca ²⁺- and phosphatidylserine (PS)-dependent histone phosphorylation with IC₅₀ of 5 μM. histone phosphorylation with IC₅₀ of 80 μM ^[1] .

HY-P11122

MSP-1 P2	IFNAR Interleukin Related	Inflammation/Immunology
MSP-1 P2 is a synthetic peptide of merozoite surface protein-1 (MSP-1). MSP-1 P2 stimulates umbilical cord blood lymphocytes to produce IFN-γ and IL-13, and this immune response is primarily mediated by CD4+ T cells. MSP-1 P2 can be used as a specific antigen stimulus to detect T cell responses and cytokine levels ^[1].

HY-P1906

[pThr3]-CDK5 Substrate	CDK	Neurological Disease
[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is derived from the sequence of the histone H1 peptide that docks in the active site of CDK5. [pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a K_m value of 6 µM ^[1].

HY-P2557

Histone H3 (5-23)	Histone Acetyltransferase	Others
Histone H3 (5-23), derived from histone H3 5-23 amino acids, can be used as a substrate for histone acetyltransferase (HAT) assays ^[1].

HY-P2556

Histone H3 (21-44)	Biochemical Assay Reagents	Others
Histone H3 (21-44), derived from histone H3 21-44 amino acids, is usually used as a substrate (such as protein arginine methyltransferases) for methylation assays ^[1].

HY-P2509

Histone H2A (1-20)	Peptides	Others
Histone H2A (1-20), a 35-residue a peptide of histone H2A, is a substrate for methyltransferase/demethylase enzymes ^[1].

HY-P10111A

Histone H3K9me3 (1-15) TFA H3(1-15)K9me3 TFA	Histone Methyltransferase	Others
Histone H3K9me3 (1-15) (H3(1-15)K9me3) TFA is used as substrate. Histone H3K9me3 is a histone posttranslational modification (PTM) that has emerged as hallmark of pericentromeric heterochromatin ^[1] .

HY-P10111

Histone H3K9me3 (1-15) H3(1-15)K9me3	Peptides	Inflammation/Immunology Cancer
Histone H3K9me3 (1-15) (H3(1-15)K9me3) is a histone posttranslational modification (PTM) that has emerged as hallmark of pericentromeric heterochromatin. Trimethylation of histone H3 at lysine 9 is associated with gene repression, prevents transcription factor binding ^[1] .

HY-P2555

Histone H3 (23-34)	Peptides	Others
Histone H3 (23-34) is the histone H3 amino acid residues 23 to 34. Histone H3 (23-34) contains lysine residues at positions 23 and 27 that are subject to methylation and acetylation ^[1].

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Parasite	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent **Plasmodium subtilisin-like protease 1 (SUB1)** inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively ^[1].

HY-P5544A

M-TriDAP TFA N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid TFA	NOD-like Receptor (NLR)	Others
M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) TFA is a *NOD1/2* agoist and biological active peptide ^[1].

HY-P2161A

TAK-683 TFA	Kisspeptin Receptor	Cancer
TAK-683 TFA is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 TFA is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively ^[1]. TAK-683 TFA depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer ^[1] .

HY-P3745

*H1-7 (histone* H1 phosphorylation site), PKA Substrate**	PKA	Others
H1-7 (histone H1 phosphorylation site), PKA Substrate, a synthetic polypeptide, can be used as PKA substrate ^[1] .

HY-P4616

*(Lys(Ac)12)-Histone* H4 (1-21)-Gly-Gly-Lys(biotinyl)**	Peptides	Others
(Lys(Ac)12)-Histone H4 (1-21)-Gly-Gly-Lys(biotinyl) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development ^[1].

HY-P4620

*(Lys(Me)24)-Histone* H3 (1-21)-Gly-Gly-Lys(biotinyl)**	Peptides	Others
(Lys(Me)24)-Histone H3 (1-21)-Gly-Gly-Lys(biotinyl) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development ^[1].

HY-P5344

Dabcyl-LNKRLLHETQ-Edans Fluorigenic PEXEL peptide	Parasite	Others
Dabcyl-LNKRLLHETQ-Edans (Fluorigenic PEXEL peptide) is a biological active peptide. (This FRET substrate peptide for Plasmepsin V (PMV) is derived from the conserved Plasmodium Export Element (PEXEL) motif of Histidine-Rich Protein II (HRPII). PMV is an ER aspartic protease that recognizes and cleaves the RXL sequence within the PEXEL motif of proteins exported by human malaria parasite Plasmodium falciparum, allowing them to translocate into host erythrocytes.)

Cat. No.	Product Name

HY-K0030

Deacetylase Inhibitor Cocktail (100× in 70% DMSO)
MCE Deacetylase Inhibitor Cocktail is a synergistic combination of chemicals designed to preserve the acetylation state of proteins.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cat. No.	Product Name	Target	Research Area	Image

HY-P99547

Trastuzumab duocarmazine (vic)-Trastuzumab duocarmazine	Antibody-Drug Conjugates (ADCs)	Cancer
Trastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) is a HER2-targeting ADC that is recognized and cleaved by histone B in tumor cells and selectively targets tumor cells. Trastuzumab duocarmazine has anti-tumor activity and can be used in cancer research related to uterine and ovarian sarcomas ^[1].

HY-P990219

Anti-Mouse IL-2 Antibody (JES6-1A12)	Interleukin Related	Infection Inflammation/Immunology
Anti-Mouse IL-2 Antibody (JES6-1A12) is an anti-mouse IL-2 IgG1 monoclonal antibody. Anti-Mouse IL-2 Antibody (JES6-1A12) can inhibit Treg amplification and enhance Th1 response. Anti-Mouse IL-2 Antibody (JES6-1A12) can form a complex with IL-2 for experimentation. Anti-Mouse IL-2 Antibody (JES6-1A12) can be used for research on infection conditions such as malaria ^[1] .

HY-P990434

*Anti-Histone* H3 Antibody**	Histone Methyltransferase	Inflammation/Immunology
The Anti-Histone H3 Antibody is a CHO-expressed humanized antibody that targets Histone H3. The Anti-Histone H3 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-Histone H3 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990433

*Anti-Histone* H2B Antibody**	Inhibitory Antibodies	Inflammation/Immunology
Anti-Histone H2B Antibody is a CHO-expressed human antibody that targets Histone H2B. Anti-Histone H2B Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-Histone H2B Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990574

Derlotuximab	Histone Methyltransferase	Inflammation/Immunology
Derlotuximab is a CHO-expressed, scFv-Fc (huIgG1) type chimeric antibody that targets Histone H1. The predicted molecular weight (MW) of Derlotuximab is 145.1 kDa. The isotype control for Derlotuximab can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990435

*Anti-Histone* H4 Antibody**	Inhibitory Antibodies	Inflammation/Immunology
Anti-Histone H4 Antibody is a CHO-expressed human antibody that targets Histone H4. Anti-Histone H4 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For the isotype control of Anti-Histone H4 Antibody, you can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990412

Anti-F8/Factor VIII Antibody	Inhibitory Antibodies	Inflammation/Immunology
Anti-F8/Factor VIII Antibody is a CHO-expressed human antibody that targets F8/Factor VIII. Anti-F8/Factor VIII Antibody has a huIgG4 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-F8/Factor VIII Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Species:	Virus (1) Human (58) Mouse (6) Xenopus laevis (7) E.coli (1)
Tag:	T7 (1) SUMO (4) His (41) Tag Free (26) Myc (6) GST (9)
Source:	E. coli Cell-free (1) Sf9 insect cells (15) E. coli (58)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72262

	Histone deacetylase 1/HDAC1 Protein, Human (His-SUMO) GON 10; HD1; HDAC1; RPD3; RPD3L1	Human	E. coli
	Studies have confirmed that the histone deacetylase 1 (HDAC1) protein is a key enzyme that deacetylates lysine residues on core histones (H2A, H2B, H3, H4). This process establishes an epigenetic repressive signature that affects transcription, cell cycle, and developmental events. Histone deacetylase 1/HDAC1 Protein, Human (His-SUMO) is the recombinant human-derived Histone deacetylase 1/HDAC1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P704097

	HDAC11 Protein, Human (His) histone deacetylase 11, HDAC11	Human	E. coli
	HDAC11 Protein, Human (His) is the recombinant human-derived HDAC11 protein, expressed by E. coli, with C-6*His tag.

HY-P702858

	HDAC8 Protein, Human (sf9) histone deacetylase 8; HD8; HDAC8; HDACL1; CDA07	Human	Sf9 insect cells
	The HDAC8 protein is a histone deacetylase that has been shown to be critical for lysine deacetylation on core histones (H2A, H2B, H3, H4). This enzymatic activity initiates epigenetic repression that affects transcription, cell cycle, and developmental events. HDAC8 Protein, Human (sf9) is the recombinant human-derived HDAC8 protein, expressed by Sf9 insect cells , with no tag.

HY-P703069

	HDAC10 Protein, Human (His) Polyamine deacetylase HDAC10; histone deacetylase 10; HD10; EC:3.5.1.48; EC:3.5.1.62	Human	E. coli
	HDAC10 Protein, Human (His) is the recombinant human-derived HDAC10, expressed by E. coli , with N-6*His labeled tag.

HY-P75144

	HDAC8 Protein, Mouse (sf9, His) histone deacetylase 8; HD8; HDAC8; HDACL1; CDA07	Mouse	Sf9 insect cells
	The HDAC8 protein is a histone deacetylase that removes acetyl groups from core histone lysine residues, contributing to epigenetic repression and affecting transcriptional regulation, cell cycle progression, and developmental events. It forms large multiprotein complexes and deacetylates SMC3, regulating the release of cohesin complexes. HDAC8 Protein, Mouse (sf9, His) is the recombinant mouse-derived HDAC8 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P704288

	HDAC10 Protein, Human (Active, sf9, GST) Polyamine deacetylase HDAC10; histone deacetylase 10; HD10; EC:3.5.1.48; EC:3.5.1.62	Human	Sf9 insect cells
	HDAC10 Protein, Human (Active, sf9, GST) is the recombinant human-derived HDAC10 protein, expressed by Sf9 insect cells, with N-GST tag.

HY-P72224

	HDAC6 Protein, Human (His) 1 Publications Verification CPBHM; FLJ16239; HD 6; HD6; HDAC 6; HDAC6; HDAC6_HUMAN; histone deacetylase 6 HD6; ; histone deacetylase 6; JM 21; JM21; KIAA0901; OTTHUMP00000032398; OTTHUMP00000197663; PPP1R90; Protein phosphatase 1 regulatory subunit 90	Human	E. coli
	The HDAC6 protein coordinates multiple functions, deacetylating histones and proteins such as tubulin and CTTN. Its role in epigenetic repression affects transcription, cell cycle, and development. HDAC6 Protein, Human (His) is the recombinant human-derived HDAC6 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P704024

	HDAC6 Protein, Human (sf9, His) CPBHM; FLJ16239; HD 6; HD6; HDAC 6; HDAC6; HDAC6_HUMAN; histone deacetylase 6 HD6; ; histone deacetylase 6; JM 21; JM21; KIAA0901; OTTHUMP00000032398; OTTHUMP00000197663; PPP1R90; Protein phosphatase 1 regulatory subunit 90	Human	Sf9 insect cells
	The HDAC6 protein coordinates multiple functions, deacetylating histones and proteins such as tubulin and CTTN. Its role in epigenetic repression affects transcription, cell cycle, and development. HDAC6 Protein, Human (sf9, His) is the recombinant human-derived HDAC6 protein, expressed by Sf9 insect cells, with C-8*His labeled tag.

HY-P77134

	*LDH Protein, P. falciparum* (His)** L-lactate dehydrogenase; PF3D7_1324900	Others	E. coli
	The pfHPRT (Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase) protein is a member of the LDH/MDH (lactate dehydrogenase/malate dehydrogenase) superfamily. It plays a crucial role in the purine metabolism salvage pathway of the malaria-causing parasite Plasmodium falciparum. LDH Protein, P. falciparum (His) is the recombinant LDH protein, expressed by E. coli , with C-His labeled tag.

HY-P74637

	*HPRT Protein, P. falciparum* (His)** L-lactate dehydrogenase; PF3D7_1324900	Others	E. coli
	The pfHPRT (Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase) protein is a member of the LDH/MDH (lactate dehydrogenase/malate dehydrogenase) superfamily. It plays a crucial role in the purine metabolism salvage pathway of the malaria-causing parasite Plasmodium falciparum. HPRT Protein, P. falciparum (His) is the recombinant HPRT protein, expressed by E. coli , with N-His labeled tag.

HY-P701944

	*Cephalosporin C deacetylase* Protein, Bacillus subtilis** cah; Cephalosporin-C deacetylase; Acetylxylan esterase	Others	E. coli
	Cephalosporin C deacetylase Protein, an esterase, selectively removes acetyl groups from substrates like acetylated xylose and cephalosporin C. Its catalytic activity excludes polymeric acetylated xylan and amide linkages, highlighting its nuanced, targeted deacetylation function. Cephalosporin C deacetylase Protein, Bacillus subtilis is the recombinant Cephalosporin C deacetylase protein, expressed by E. coli , with tag free.

HY-P71592

	Sap130 Protein, Mouse (His) Sap130; histone deacetylase complex subunit SAP130; 130kDa Sin3-associated polypeptide; Sin3-associated polypeptide p130	Mouse	E. coli
	Sap130 Protein, a transcriptional repressor, participates in mSin3A corepressor complex assembly or enzymatic activity. It's a component of the complex, including SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1, and HDAC2. Sap130 also interacts with CLEC4E, especially when released by dead or dying cells. Sap130 Protein, Mouse (His) is the recombinant mouse-derived Sap130 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P704100

	AADAC Protein, Human (His) AAAD_HUMAN; Aada; Aadac; Arylacetamide deacetylase (esterase); Arylacetamide deacetylase; CES5A1; DAC	Human	E. coli
	AADAC Protein, Human (His) is the recombinant human-derived AADAC protein, expressed by E. coli, with N-10*His tag.

HY-P72798

	Histone H3 Protein, Human (His) histone H3.1; histone H3	Human	E. coli
	Histone H3 proteins are critical in nucleosomes, which compact DNA into chromatin and regulate DNA accessibility. Histone H3 Protein, Human (His) is the recombinant human-derived Histone H3 protein, expressed by E. coli , with N-His labeled tag.

HY-P705933

	NCEH1 Protein, Human (His) NCEH; Acetylalkylglycerol acetylhydrolase; 2-acetyl MAGE hydrolase; Arylacetamide deacetylase-like 1	Human	E. coli

HY-P71488

	LpxC Protein, E.coli (His) lpxC; asmB; envA; b0096; JW0094; UDP-3-O-acyl-N-acetylglucosamine deacetylase; UDP-3-O-acyl-GlcNAc deacetylase; EC 3.5.1.108; Protein EnvA; UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase	E.coli	E. coli
	LpxC protein serves as a key enzyme in lipid A biosynthesis by catalyzing the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine, marking a key and crucial step in this important pathway. Through this enzymatic process, LpxC promotes the conversion of its substrate into UDP-3-O-myristoylglucosamine and acetate, making a significant contribution to lipid A biosynthesis. LpxC Protein, E.coli (His) is the recombinant E. coli-derived LpxC protein, expressed by E. coli , with N-His labeled tag.

HY-P72328

	H2AC4 Protein, Human " histone H2A type 1-B/E; histone H2A.2; histone H2A/a; histone H2A/m; H2AFM"	Human	E. coli
	The H2AC4 protein is a core component of nucleosomes, which compress DNA into chromatin and restrict DNA entry into cellular processes. H2AC4 Protein, Human is the recombinant human-derived H2AC4 protein, expressed by E. coli , with tag free.

HY-P74887

	Histone H1 Protein, Human (His) 1 Publications Verification histone H1.0; histone H1(0); H1-0; H1F0; H1FV	Human	E. coli
	Histone H1 proteins, particularly the H1.0 variant, are crucial for condensing nucleosome chains, organizing and compacting chromatin. H1.0 is prevalent in cells undergoing terminal differentiation or with low cell division rates. Histone H1 Protein, Human (His) is the recombinant human-derived Histone H1 protein, expressed by E. coli , with N-His labeled tag.

HY-P703460

	Histone-H3 Protein, Xenopus laevis histone H3; LOC121398065; LOC108703785; LOC121398067; Xenopus laevis; African clawed frog; DNA-binding	Xenopus laevis	E. coli
	Histone-H3 Protein, Xenopus laevis is the recombinant Xenopus laevis-derived Histone-H3, expressed by E. coli , with tag Free labeled tag.

HY-P701616

	PHF8 Protein, Human PHF8; histone lysine demethylase PHF8; PHD finger protein 8; [histone H3]-dimethyl-L-lysine(36) demethylase PHF8; [histone H3]-dimethyl-L-lysine(9) demethylase PHF8	Human	E. coli
	The PHF8 protein is a histone lysine demethylase that plays a key role in cell cycle progression, rDNA transcription, and brain development. It selectively demethylates H3 'Lys-9' (H3K9Me1 and H3K9Me2), H3 'Lys-27' (H3K27Me2) and H4 'Lys-20' (H4K20Me1). PHF8 Protein, Human is the recombinant human-derived PHF8 protein, expressed by E. coli , with tag free.

HY-P72332

	Histone H3 Protein, Human 1 Publications Verification H3C1	Human	E. coli
	Histone H3 proteins are critical in nucleosomes, which compact DNA into chromatin and regulate DNA accessibility. Histone H3 Protein, Human is the recombinant human-derived Histone H3 protein, expressed by E. coli , with tag free.

HY-P701617

	PHF8 Protein, Human (His) PHF8; histone lysine demethylase PHF8; PHD finger protein 8; [histone H3]-dimethyl-L-lysine(36) demethylase PHF8; [histone H3]-dimethyl-L-lysine(9) demethylase PHF8	Human	E. coli
	The PHF8 protein is a histone lysine demethylase that plays a key role in cell cycle progression, rDNA transcription, and brain development. It selectively demethylates H3 'Lys-9' (H3K9Me1 and H3K9Me2), H3 'Lys-27' (H3K27Me2) and H4 'Lys-20' (H4K20Me1). PHF8 Protein, Human (His) is the recombinant human-derived PHF8 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P705927

	HDAC3 Protein, Human (His) Protein deacetylase HDAC3; Protein deacylase HDAC3; RPD3-2; SMAP45	Human	E. coli
	HDAC3 is a Class I member of the histone deacetylase superfamily. HDAC3 Protein, Human (His) is the recombinant human-derived HDAC3 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P72336

	Histone H4 Protein, Human/Xenopus laevis H4C1	Xenopus laevis;Human	E. coli
	Histone H4 proteins are core components of nucleosomes, which compact DNA into chromatin and regulate DNA accessibility during cellular processes. Histones, including H4, play critical roles in transcriptional regulation, DNA repair, replication, and chromosome stability. Histone H4 Protein, Human/Xenopus laevis is the recombinant Xenopus laevis-derived Histone H4 protein, expressed by E. coli , with tag free.

HY-P70279

	Esterase D/FGH Protein, Human (His) rHuS-formylglutathione hydrolase/FGH, His; S-Formylglutathione Hydrolase; FGH; Esterase D; Methylumbelliferyl-Acetate deacetylase; ESD	Human	E. coli
	Esterase D/FGH Protein, Human (His) is the recombinant human-derived Esterase D/FGH protein, expressed by E. coli, with C-6*His labeled tag.

HY-P701618

	JMJD2A Protein, Human KDM4A; Lysine-specific demethylase 4A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A; [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A	Human	E. coli
	The JMJD2A protein is a central histone demethylase in the histone code that specifically targets "Lys-9" and "Lys-36" of histone H3. It excludes demethylation of H3 "Lys-4", "Lys-27" and H4 "Lys-20". JMJD2A Protein, Human is the recombinant human-derived JMJD2A protein, expressed by E. coli , with tag free.

HY-P705951

	H2AX Protein, Human (GST) H2A histone family member X ; H2A histone family member X; H2A.FX; H2A.X; H2a/x; H2AFX; H2AX; H2AX_HUMAN; histone H2A.X	Human	E. coli

HY-P72330

	Histone H2A Protein, Xenopus laevis h2ac14.L	Xenopus laevis	E. coli
	Histone H2A, an integral nucleosome component, forms the histone octamer with H2B, H3, and H4. This molecular spool, consisting of two H2A-H2B heterodimers and one H3-H4 heterotetramer, wraps around approximately 147 base pairs of DNA, organizing chromatin structure. The intricate histone-DNA association, especially with H2A, plays a vital role in regulating cellular processes like gene expression and DNA packaging. Histone H2A Protein, Xenopus laevis is the recombinant Xenopus laevis-derived Histone H2A protein, expressed by E. coli , with tag free.

HY-P76381

	HIST2H2BE Protein, Human histone H2B type 2-E; histone H2B-GL105; H2B/q; H2BC21; H2BFQ	Human	E. coli
	The HIST2H2BE protein is a core component of nucleosomes, key structures in chromatin organization that wrap and compact DNA, controlling its accessibility to cellular machinery based on DNA templates. This integral role of histones, including HIST2H2BE, extends to transcriptional regulation, DNA repair, DNA replication, and chromosomal stability. HIST2H2BE Protein, Human is the recombinant human-derived HIST2H2BE protein, expressed by E. coli , with tag free.

HY-P72335

	Histone H3 Protein, Human (98a.a, His) H3C1	Human	E. coli
	Histone H3 proteins are critical in nucleosomes, which compact DNA into chromatin and regulate DNA accessibility. Histone H3 Protein, Human (98a.a, His) is the recombinant human-derived Histone H3 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P72331

	Histone H2B 1.1 Protein, Xenopus laevis H2B1.1	Xenopus laevis	E. coli
	Histone H2B 1.1 protein is a key nucleosome component that compacts DNA into chromatin, thereby restricting access to cellular processes. Histone H2B 1.1 Protein, Xenopus laevis is the recombinant Xenopus laevis-derived Histone H2B 1.1 protein, expressed by E. coli , with tag free.

HY-P72333

	Histone H3 Protein, Xenopus laevis (135a.a) h3c8.S	Xenopus laevis	E. coli
	Histone H3 Protein constitutes a core element in the nucleosome, an octamer comprising H2A, H2B, H3, and H4. The assembly forms a histone octamer with one H3-H4 heterotetramer and two H2A-H2B heterodimers, serving as a molecular spool that wraps around 147 base pairs of DNA. This compact organization contributes to chromatin structure, and Histone H3, as part of this assembly, plays a crucial role in chromatin structure and gene regulation. Histone H3 Protein, Xenopus laevis (135a.a) is the recombinant Xenopus laevis-derived Histone H3 protein, expressed by E. coli , with tag free.

HY-P703458

	Histone-H2B Protein, Xenopus laevis H2BFL; HIST1H2BC	Xenopus laevis	E. coli
	Histone-H2B Protein, Xenopus laevis is the recombinant Xenopus laevis-derived Histone-H2B, expressed by E. coli , with tag Free labeled tag. ,

HY-P702963

	EP300 Protein, Mouse (His, Myc) P300; p300 HAT; histone acetyltransferase p300	Mouse	E. coli
	EP300 Protein, Mouse (His, Myc) is the recombinant Mouse-derived EP300,with His, Myc labeled tag.

HY-P72329

	H2BC11 Protein, Human H2BC11; histone H2B type 1-J	Human	E. coli
	The H2BC11 protein functions as a core component of nucleosomes, the fundamental units in chromatin structure that wrap and compact DNA, regulating its accessibility to cellular processes that require DNA as a template. Histones, including H2BC11, play central roles in transcriptional regulation, DNA repair, DNA replication, and chromosome stability. H2BC11 Protein, Human is the recombinant human-derived H2BC11 protein, expressed by E. coli , with tag free.

HY-P700258

	SMYD3 Protein, Human (His-Myc) histone-lysine N-methyltransferase SMYD3; ZMYND1; ZNFN3A1	Human	E. coli
	SMYD3 Protein, a histone methyltransferase, specifically induces di- and tri-methylation of H3K4, avoiding monomethylation, and methylates H4K5. Crucial in transcriptional activation within an RNA polymerase complex, SMYD3 also exhibits DNA-binding affinity for sequences containing 5'-CCCTCC-3' or 5'-GAGGGG-3'. Histone-lysine N-methyltransferase SMYD3 (SMYD3) Protein, Human (His-Myc) is the recombinant human-derived Histone-lysine N-methyltransferase SMYD3(SMYD3) protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. Histone-lysine N-methyltransferase SMYD3 (SMYD3) Protein, Human (His-Myc), has molecular weight of 56.5 kDa.

HY-P700380

	ACKR1 Protein, Human (Cell-Free, His) ACKR1; atypical chemokine receptor 1 (Duffy blood group); DARC; Duffy blood group, chemokine receptor; Duffy blood group , FY; Duffy antigen/chemokine receptor; CCBP1; CD234; Dfy; GPD; glycoprotein D; Fy glycoprotein; Duffy blood group antigen; Plasmodium vivax receptor; FY; GpFy; WBCQ1;	Human	E. coli Cell-free
	ACKR3 is an atypical chemokine receptor that regulates chemokine levels and localization through high-affinity binding, induction of sequestration, degradation, or transcytosis. ACKR3, also known as a chemokine interceptor or decoy receptor, binds to chemokines such as CXCL11 and CXCL12/SDF1. ACKR1 Protein, Human (Cell-Free, His) is the recombinant human-derived ACKR1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P76080

	SMYD3 Protein, Human (sf9, GST) histone-lysine N-methyltransferase SMYD3; ZMYND1; ZNFN3A1	Human	Sf9 insect cells
	SMYD3 Protein, a histone methyltransferase, specifically induces di- and tri-methylation of H3K4, avoiding monomethylation, and methylates H4K5. Crucial in transcriptional activation within an RNA polymerase complex, SMYD3 also exhibits DNA-binding affinity for sequences containing 5'-CCCTCC-3' or 5'-GAGGGG-3'. SMYD3 Protein, Human (sf9, GST) is the recombinant human-derived SMYD3 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P77218

	SUV420H2 Protein, Human (His) histone-lysine N-methyltransferase KMT5C; KMT5C; PP7130	Human	E. coli
	SUV420H2 protein is a histone methyltransferase that methylates H4K20 to generate H4K20me3 and H4K20me2, which are critical for transcriptional regulation and genome integrity. SUV420H2 functions in pericentric heterochromatin, establishes constitutive heterochromatin, and interacts with RB1 family proteins. SUV420H2 Protein, Human (His) is the recombinant human-derived SUV420H2 protein, expressed by E. coli , with N-His labeled tag.

HY-P703143

	Histone H3.3 Protein, Human H3.3A; H3F3; H3F3A	Human	E. coli
	Histone H3.3 Protein, Human is the recombinant human-derived Histone H3.3 protein, expressed by E. coli, with tag free tag.

HY-P701609

	SIRT3 Protein, Human SIRT3; NAD-dependent protein deacetylase sirtuin-3; mitochondrial; hSIRT3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3	Human	E. coli
	SIRT3 is an NAD-dependent protein deacetylase that dynamically affects the acetylation of mitochondrial target proteins, such as ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA, and the ATP synthase subunit ATP5PO. Its deacetylation activity regulates cellular energy metabolism and fine-tunes tissue-specific ATP levels. SIRT3 Protein, Human is the recombinant human-derived SIRT3 protein, expressed by E. coli , with tag free.

HY-P74601

	RBBP4 Protein, Human (sf9, His) histone-binding protein RBBP4; CAF-I p48; RBBP-4; RBAP48	Human	Sf9 insect cells
	The RBBP4 protein regulates chromatin assembly by binding to core histones and interacting with chromatin assembly factors, remodelers, and histone deacetylases. Its activity is determined by its interaction with nucleosomal DNA. RBBP4 Protein, Human (sf9, His) is the recombinant human-derived RBBP4 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P74600

	RBBP4 Protein, Mouse (sf9, His) histone-binding protein RBBP4; CAF-I p48; RBBP-4; RBAP48	Mouse	Sf9 insect cells
	The RBBP4 protein is a core histone-binding subunit that directs chromatin regulators and histone deacetylases to their substrates and participates in chromatin metabolism.RBBP4 Protein, Mouse (sf9, His) is the recombinant mouse-derived RBBP4 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P703147

	Histone H3.3 Protein, Human (His) H3.3A; H3F3; H3F3A	Human	E. coli
	Histone H3.3 Protein, Human (His) is the recombinant human-derived Histone H3.3 protein, expressed by E. coli, with His tag.

HY-P701610

	SIRT3 Protein, Human (His, SUMO) SIRT3; NAD-dependent protein deacetylase sirtuin-3; mitochondrial; hSIRT3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3	Human	E. coli
	SIRT3 is an NAD-dependent protein deacetylase that dynamically affects the acetylation of mitochondrial target proteins, such as ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA, and the ATP synthase subunit ATP5PO. Its deacetylation activity regulates cellular energy metabolism and fine-tunes tissue-specific ATP levels. SIRT3 Protein, Human (His, SUMO) is the recombinant human-derived SIRT3 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P702774

	SIRT3 Protein, Mouse (His, Myc) SIRT3; NAD-dependent protein deacetylase sirtuin-3; mitochondrial; hSIRT3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3	Mouse	E. coli
	SIRT3 Protein, Mouse (His, Myc) is the recombinant mouse-derived SIRT3, expressed by E. coli , with N-10*His, C-Myc labeled tag. ,

HY-P704206

	KAT6B Protein, Human (Active, sf9, GST) KIAA0383; MORF; MOZ2; MYST4histone acetyltransferase KAT6B; histone acetyltransferase MOZ2; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4 (MYST-4); Monocytic leukemia zinc finger protein-related factor	Human	Sf9 insect cells
	KAT6B Protein, Human (Active, sf9, GST) is the recombinant human-derived KAT6B protein, expressed by Sf9 insect cells, with N-GST tag.

HY-P703144

	Histone H3.3 Protein, Human (K27M) H3.3A; H3F3; H3F3A	Human	E. coli
	Histone H3.3 Protein, Human (K27M) is the recombinant human-derived Histone H3.3 protein, expressed by E. coli, with tag free tag.

HY-P703145

	Histone H3.3 Protein, Human (G34R) H3.3A; H3F3; H3F3A	Human	E. coli
	Histone H3.3 Protein, Human (G34R) is the recombinant human-derived Histone H3.3 protein, expressed by E. coli, with tag free tag.

HY-P703146

	Histone H3.3 Protein, Human (G34V) H3.3A; H3F3; H3F3A	Human	E. coli
	Histone H3.3 Protein, Human (G34V) is the recombinant human-derived Histone H3.3 protein, expressed by E. coli, with tag free tag.

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Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (60) Rabbit (142)
Reactivity:	Xenopus (1) Human (194) C. elegans (1) Bovine (3) Rat (134) Drosophila (1) Monkey (16) Rabbit (2) Zebrafish (2) Pig (2) Oryza sativa (1) Mouse (157) broad mammalian (1) human (2) Dog (5)
Application:	IHC-P (121) ICC/IF (138) CHIP (8) IF-Tissue (16) IP (67) Cut&Tag (9) IHC-F (11) WB (199) ChIP (37) FC (35) Dot Blot (9) ELISA (48)
Isotype:	IgG,Kappa (7) IgG (127) IgG, Kappa (4) IgG1 (19) IgG, Kappa (1) IgG1,IgG/Kappa (1) IgG/Kappa (3) IgG2a (6) IgG2b (3) IgM (1) IgG,IgG/Kappa (2)
Conjugation:	HRP (1) Non-conjugated (201)
Clonality:	Polyclonal (1) polyclonal (1) Monoclonal (149) Recombinant (86)
Modification:	Methylated (35) Phosphorylated (12) Acetylated (29) Unmodified (100) Hydroxylated (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85878

	HDAC1 Antibody (YA5570) histone deacetylase 1; HD1;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	HDAC1 Antibody (YA5570) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HDAC1.

HY-P86491

	HDAC1 Antibody (YA6183) HDAC1; RPD3L1; histone deacetylase 1; HD1	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	HDAC1 Antibody (YA6183) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC1.

HY-P810685

	Histone deacetylase Antibody histone deacetylase	WB	Oryza sativa
	Histone deacetylase Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Histone deacetylase.

HY-P83401

	HDAC7 Antibody (YA3146) HDAC7; HDAC7A; histone deacetylase 7; HD7; histone deacetylase 7A; HD7a	WB, FC	Human, Mouse, Rat
	HDAC7 Antibody (YA3146) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC7.

HY-P80699

	HDAC2 Antibody (YA742) HDAC2; histone deacetylase 2; HD2	WB, ICC/IF	Human, Mouse, Rat, Monkey
	HDAC2 Antibody (YA742) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HDAC2.

HY-P83139

	HDAC11 Antibody (YA2884) HDAC11; HD11; histone deacetylase 11	WB, IP	Human
	HDAC11 Antibody (YA2884) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC11.

HY-P86612

	HDAC2 Antibody (YA6304) HDAC2; histone deacetylase 2; HD2	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	HDAC2 Antibody (YA6304) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC2.

HY-P83222

	HDAC9 Antibody (YA2967) histone deacetylase 9; HD9; histone deacetylase 7B; HD7; HD7b; histone deacetylase-related protein; MEF2-interacting transcription repressor MITR; HDAC9; HDAC7; HDAC7B; HDRP; KIAA0744; MITR	WB, IHC-P	Human
	HDAC9 Antibody (YA2967) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC9.

HY-P83222A

	HDAC9 Antibody (YA2967)(PBS only) histone deacetylase 9; HD9; histone deacetylase 7B; HD7; HD7b; histone deacetylase-related protein; MEF2-interacting transcription repressor MITR; HDAC9; HDAC7; HDAC7B; HDRP; KIAA0744; MITR	WB, IHC-P	Human
	HDAC9 Antibody (YA2967) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC9.

HY-P86323

	HDAC4 Antibody (YA6015) HDAC4; KIAA0288; histone deacetylase 4; HD4	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	HDAC4 Antibody (YA6015) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC4.

HY-P80699A

	HDAC2 Antibody (YA742)(PBS only) HDAC2; histone deacetylase 2; HD2	WB, ICC/IF	Human, Mouse, Rat, Monkey
	HDAC2 Antibody (YA742) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HDAC2.

HY-P83249

	HDAC8 Antibody (YA2994) HDAC8; HDACL1; CDA07; histone deacetylase 8; HD8	WB, IP	Human
	HDAC8 Antibody (YA2994) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC8.

HY-P86103

	HDAC6 Antibody (YA5795) HDAC6; KIAA0901; JM21; histone deacetylase 6; HD6	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	HDAC6 Antibody (YA5795) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC6.

HY-P80701

	HDAC6 Antibody (YA740) HDAC6; KIAA0901; JM21; histone deacetylase 6; HD6	WB	Human, Rat
	HDAC6 Antibody (YA740) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HDAC6.

HY-P85198

	HDAC3 Antibody (YA4890) HDAC3; histone deacetylase 3; HD3; RPD3-2; SMAP45	WB, ICC/IF, ELISA	Human, Mouse
	HDAC3 Antibody (YA4890) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HDAC3.

HY-P85432

	HDAC3 Antibody (YA5124) HDAC3; histone deacetylase 3; HD3; RPD3-2; SMAP45	WB	Human, Mouse, Rat, Dog, Pig, Rabbit
	HDAC3 Antibody (YA5124) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HDAC3.

HY-P80701A

	HDAC6 Antibody (YA740)(PBS only) HDAC6; KIAA0901; JM21; histone deacetylase 6; HD6	WB	Human, Rat
	HDAC6 Antibody (YA740) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HDAC6.

HY-P83249A

	HDAC8 Antibody (YA2994)(PBS only) HDAC8; HDACL1; CDA07; histone deacetylase 8; HD8	WB, IP	Human
	HDAC8 Antibody (YA2994) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC8.

HY-P85198A

	HDAC3 Antibody (YA4890)(PBS only) HDAC3; histone deacetylase 3; HD3; RPD3-2; SMAP45	WB, ICC/IF, ELISA	Human, Mouse
	HDAC3 Antibody (YA4890) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HDAC3.

HY-P80700

	HDAC4 Antibody (YA741) EC 3.5.1.98; HA6116; HD 4; HD4; HDAC 4; HDAC A; HDAC4; HDAC4_HUMAN; HDACA; histone deacetylase 4; histone deacetylase A; KIAA0288.	WB, IP	Human, Mouse, Rat, Monkey
	HDAC4 Antibody (YA741) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HDAC4.

HY-P80700A

	HDAC4 Antibody (YA741)(PBS only) EC 3.5.1.98; HA6116; HD 4; HD4; HDAC 4; HDAC A; HDAC4; HDAC4_HUMAN; HDACA; histone deacetylase 4; histone deacetylase A; KIAA0288.	WB, IP	Human, Mouse, Rat, Monkey
	HDAC4 Antibody (YA741) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HDAC4.

HY-P85562

	HDAC3 Antibody (YA5254) HD 3; HD3; HDAC 3; HDAC3; HDAC3_HUMAN; histone deacetylase 3; HD3; RPD3-2; histone deacetylase 3; RPD 3; RPD3 2; RPD3; RPD3-2; SMAP 45; SMAP45.	WB	Human, Mouse, Rat
	HDAC3 Antibody (YA5254) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HDAC3.

HY-P86450

	Phospho-AKT(Ser473) Antibody (YA6142) (YA6142) KIAA0600, HDAC5, histone deacetylase 5, HD5, Antigen NY-CO-9	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Phospho-AKT(Ser473) Antibody (YA6142) (YA6142) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-AKT(Ser473).

HY-P83623

	mSin3A Antibody (YA3368) histone deacetylase complex subunit Sin 3a; Paired amphipathic helix protein Sin 3a; SIN3 homolog A	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	mSin3A Antibody (YA3368) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to mSin3A.

HY-P86897

	HDAC5 Antibody (YA6590) Antigen NY CO 9 antibody; Antigen NY-CO-9 antibody; HD5 antibody; HDAC 5 antibody; HDAC5 antibody; HDAC5_HUMAN antibody; histone deacetylase 5 antibody; NY CO 9 antibody;	IHC-P, ICC/IF, IP, ChIP	Human, Mouse, Rat
	HDAC5 Antibody (YA6590) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC5.

HY-P83261

	Histone H1.3 Antibody (YA3006) histone H1c; histone H1s-2	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Histone H1.3 Antibody (YA3006) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H1.3.

HY-P83261A

	Histone H1.3 Antibody (YA3006)(PBS only) histone H1c; histone H1s-2	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Histone H1.3 Antibody (YA3006) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H1.3.

HY-P83304

	*Phospho-Histone* H1.4 (Thr17) Antibody (YA3049)** histone H1b; histone H1s-4	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Phospho-Histone H1.4 (Thr17) Antibody (YA3049) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Histone H1.4 (Thr17).

HY-P83263

	Histone H2A Antibody (YA3008) histone H2A.2	WB	Human, Rat
	Histone H2A Antibody (YA3008) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H2A.

HY-P83263A

	Histone H2A Antibody (YA3008)(PBS only) histone H2A.2	WB	Human, Rat
	Histone H2A Antibody (YA3008) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H2A.

HY-P80176

	Histone H3 (tri methyl K9) Antibody (YA734) H3K9me3; H3 histone family member E pseudogene; H3 histone family, memberA; H3/A; H31_HUMAN; H3F3; H3FA; Hist1h3a; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST3H3; histone 1, H3a; histone cluster 1, H3a; histone H3 3 pseudogene; histone H3.1; histone H3/a; histone H3/b; histone H3/c; histone H3/d; histone H3/f; histone H3/h; histone H3/i; histone H3/j; histone H3/k; histoneH3/l; H3K9me2; histoneH3(trimethylK9)	WB, IHC-P, ICC/IF, IF-Tissue	Human, Mouse, Rat
	Histone H3 (tri methyl K9) Antibody (YA734) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Histone H3 (tri methyl K9).

HY-P85684

	Histone H2B Antibody (YA5376) HIST1H2BB; H2BFF; histone H2B type 1-B; histone H2B.1; histone H2B.f; H2B/f	WB, ICC/IF	Human, Mouse, Rat
	Histone H2B Antibody (YA5376) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Histone H2B.

HY-P86131

	Histone H2A (Ubiquityl Lys119) Antibody (YA5823) histone H2A type 1; H2A.1; histone H2A/p;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Histone H2A (Ubiquityl Lys119) Antibody (YA5823) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H2A (Ubiquityl Lys119).

HY-P81287

	*MonoMethyl-Histone* H3 Antibody (YA997)** H3K79me; H3 histone; HIST1H3A; histone cluster 1; H3a	WB, IHC-P	Human, Mouse, Rat
	MonoMethyl-Histone H3 Antibody (YA997) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MonoMethyl-Histone H3.

HY-P86672

	Histone H3 Antibody (YA6364) 1 Publications Verification H3 histone family member E pseudogene; H3 histone family, member A; H3/A; H31_HUMAN; H3F3; H3FA; Hist1h3a; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST3H3; histone 1, H3a; histone cluster 1, H3a; histone H3 3 pseudogene; histone H3.1; histone H3/a; histone H3/b; histone H3/c; histone H3/d; histone H3/f; histone H3/h; histone H3/i; histone H3/j; histone H3/k; histone H3/l; H3.1; H3/d; H3C1; H3C10; H3C11; H3C12; H3C2; H3C3; H3C4; H3C7; H3C8; H3FD;	IHC-P, IHC-F, IF-Tissue, WB, FC, ICC/IF	Human, Rat, Mouse
	Histone H3 Antibody (YA6364) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H3.

HY-P80166

	Histone H3 Antibody (YA368) 2 Publications Verification	WB, ICC/IF, IHC-P, IP, ChIP	Human, Mouse, Rat
	Histone H3 Antibody is a non-conjugated and Rabbit origined IgG monoclonal antibody, targeting to Histone H3. It can be used as a loading control antibody.

HY-P80178

	Histone H4 Antibody (YA363) 1 Publications Verification	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Histone H4 Antibody (YA363) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H4.

HY-P87872

	Histone H3 Antibody (YA7557)	WB, IHC-P, ICC/IF, IP, ELISA, CHIP, Cut&Tag	Human, Mouse, Rat
	Histone H3 Antibody (YA7557) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Histone H3.

HY-P810558

	Acetyl-Histone H3 (Lys18) Antibody H3K27me3; H3 histone; HIST1H3A; histone cluster 1; H3a	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Acetyl-Histone H3 (Lys18) Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Acetyl-Histone H3 (Lys18).

HY-P810559

	*MonoMethyl-Histone* H3 (Lys4) Antibody** H3K27me3; H3 histone; HIST1H3A; histone cluster 1; H3a	WB, ICC/IF, IHC-P, FC, Dot Blot	Human, Mouse, Rat
	MonoMethyl-Histone H3 (Lys4) Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to MonoMethyl-Histone H3 (Lys4).

HY-P810560

	*DiMethyl-Histone* H3 (Lys4) Antibody** H3K27me3; H3 histone; HIST1H3A; histone cluster 1; H3a	WB, ICC/IF, IHC-P, FC, Dot Blot	Human, Mouse, Rat
	DiMethyl-Histone H3 (Lys4) Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to DiMethyl-Histone H3 (Lys4).

HY-P80643

	*DiMethyl-Histone* H3 Antibody (YA783)** H3K27me2; H3 histone; HIST1H3A; histone cluster 1; H3a	WB, ICC/IF, IP	Human, Mouse, Rat
	DiMethyl-Histone H3 Antibody (YA783) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DiMethyl-Histone H3.

HY-P810572

	Acetyl-Histone H3 (Lys27) Antibody H3K27me3; H3 histone; HIST1H3A; histone cluster 1; H3a	WB, IHC-P, ChIP	Human, Mouse, Rat
	Acetyl-Histone H3 (Lys27) Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Acetyl-Histone H3 (Lys27).

HY-P85652

	Histone H3 Antibody (YA5344) HIST1H3A; H3FA; HIST1H3B; H3FL; HIST1H3C; H3FC; HIST1H3D; H3FB; HIST1H3E; H3FD; HIST1H3F; H3FI; HIST1H3G; H3FH; HIST1H3H; H3FK; HIST1H3I; H3FF; HIST1H3J; H3FJ; histone H3.1; histone H3/a; histone H3/b; histone H3/c; histone H3/d; histone H3/f; histone H3/h; histone H3/i; histone H3/j; histone H3/k; histone H3/l; HIST2H3A; HIST2H3C; H3F2; H3FM; HIST2H3D; histone H3.2; histone H3/m; histone H3/o; H3F3A; H3.3A; H3F3; PP781; H3F3B; H3.3B; histone H3.3	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Histone H3 Antibody (YA5344) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Histone H3.

HY-P80922

	*TriMethyl-Histone* H3 (Lys27) Antibody (YA030)** 1 Publications Verification H3K27me3; H3 histone; HIST1H3A; histone cluster 1; H3a	WB, IHC-F, IHC-P, ICC/IF, IP, ChIP	Human, Rat
	TriMethyl-Histone H3 (Lys27) Antibody (YA030) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TriMethyl-Histone H3 (Lys27).

HY-P810556

	*TriMethyl-Histone* H3 (Lys27) Antibody (YA9825)** H3K27me3; H3 histone; HIST1H3A; histone cluster 1; H3a	WB, ICC/IF, IHC-P, IF-Tissue, ChIP	Human, Mouse, Rat
	TriMethyl-Histone H3 (Lys27) Antibody (YA9825) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to TriMethyl-Histone H3 (Lys27).

HY-P810561

	Acetyl-Histone H3 (Lys9) Antibody (YA9827) H3K27me3; H3 histone; HIST1H3A; histone cluster 1; H3a	WB, ICC/IF, IHC-P, IF-Tissue, FC, ChIP, Dot Blot, IP	Human, Mouse, Rat
	Acetyl-Histone H3 (Lys9) Antibody (YA9827) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Acetyl-Histone H3 (Lys9).

HY-P810565

	*DiMethyl-Histone* H3 (Lys27) Antibody (YA9831)** H3K27me3; H3 histone; HIST1H3A; histone cluster 1; H3a	WB, ICC/IF, ChIP	Human, Mouse, Rat
	DiMethyl-Histone H3 (Lys27) Antibody (YA9831) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to DiMethyl-Histone H3 (Lys27).

HY-P810567

	*MonoMethyl-Histone* H3 (Lys4) Antibody (YA9833)** H3K27me3; H3 histone; HIST1H3A; histone cluster 1; H3a	WB, ICC/IF, ChIP, Dot Blot	Human, Mouse, Rat
	MonoMethyl-Histone H3 (Lys4) Antibody (YA9833) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to MonoMethyl-Histone H3 (Lys4).

HY-P810574

	*MonoMethyl-Histone* H3 (Lys79) Antibody (YA9839)** H3K27me3; H3 histone; HIST1H3A; histone cluster 1; H3a	WB, ICC/IF, IHC-P, FC, ChIP	Human, Mouse, Rat, Monkey
	MonoMethyl-Histone H3 (Lys79) Antibody (YA9839) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to MonoMethyl-Histone H3 (Lys79).

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Clonality
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Appearance
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SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-145746

Sulfo-Cy5 azide		Azide Labeling and Fluorescence Imaging
Sulfo-Cy5 azide is a near-infrared fluorescent probe with favorable click chemistry reactivity. Sulfo-Cy5 azide enables fluorescence imaging, tissue and cellular visualization of *PD-L1* in tumors, and site-specific modification of anti-PD-L1 antibodies. Sulfo-Cy5 azide has been employed for RNA labeling and imaging. Sulfo-Cy5 azide can be conjugated to targeting agents for fluorescence imaging in atherosclerosis and breast cancer models (Ex/Em = 645/670 nm) ^[1] .

HY-126943

SAHA-BPyne		Alkynes
SAHA-BPyne is an activity-based protein profiling (ABPP) probe for detecting HDAC activity, which covalently labels the proximal proteins through a photoactivation. SAHA-BPyne inhibits HDAC activity in HeLa nuclear lysate with an IC₅₀ of less than 5 μM ^[1].

HY-118783

2-Hexyl-4-pentynoic acid (±)-2-Hexyl-4-pentynoic acid		Alkynes
2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), a Valproic acid (HY-10585) derivative, exhibits potential roles of HDAC inhibition (IC₅₀ = 13 μM) and HSP70 induction. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons. 2-Hexyl-4-pentynoic acid can be used for the study of breast carcinoma. 2-Hexyl-4-pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups ^[1] .

HY-131455A

Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA		Azide
Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA is used for detection of modification site for N-myristoylated and GPI-anchored proteins in blood-stage P. falciparum ^[1]. Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 (TFA) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-186091

AcdK		Azide
AcdK is a non-natural amino acid and a precursor of allysine. AcdK allows site-specific incorporation into target proteins in E. coli via the amber suppression strategy. AcdK enables site-specific lysine dimethylation or monomethylation modification of target proteins. AcdK can synthesize site-specific lysine-methylated variants of histone H3 and p53, which is applicable for investigating the substrate specificity and catalytic function of epigenetic enzymes ^[1].

HY-181849

MS2928		Alkynes
MS2928 is a selective SETD8 inhibitor with an IC₅₀ of 0.14 μM against SETD8 methyltransferase activity. MS2928 reduces cellular *H4K20_me1* levels and inhibits proliferation of SETD8-overexpressing multiple myeloma cells. MS2928 inhibits tumor growth in xenograft mouse models of SETD8-overexpressing multiple myeloma. MS2928 can be used for the study of SETD8 biological functions and multiple myeloma ^[1].

Cat. No.	Product Name		Classification

HY-N6664

Gum arabic Arabic gum		Emulsifiers Suspending Agents
Gum Arabic is an orally active complex branched polysaccharide. Gum Arabic can be isolated from the Acacia senegal tree. Gum Arabic upregulates the expression of maturation markers (CD86, CD40, and CD54), promotes *ERK1/2* phosphorylation, and inhibits Apoptosis. Gum Arabic exhibits antimalarial effects against Plasmodium berghei ANKA. Gum Arabic exhibits hepatoprotective, renal, and cardiovascular protective activities. Gum Arabic improves obesity. Gum Arabic is commonly used as a stabilizer and thickener. Gum Arabic can be used in the research of brain tumor imaging ^[1] .

HY-174678

Human FOXA3 mRNA		mRNA
Human FOXA3 mRNA encodes the human forkhead box A3 (FOXA3) protein which is thought to act as a ''pioneer'' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites.

HY-185051

OTX-2002		mRNA Gene Editing
OTX-2002 is an mRNA encoding two bifunctional fusion proteins (ZFBD-MQ1 and ZFBD-KRAB). OTX-2002 targets regulatory elements located within the MYC protection gene domain (IGD) and induces the methylation of DNA and histone, leading to the downregulation of MYC expression.

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Plasmodium falciparum histone deacetylase 1

Inhibitors & Agonists

Screening Libraries

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