HDAC10 Protein, Human (Active, sf9, GST)
HDAC10 Protein, Human (Active, sf9, GST) is the recombinant human-derived HDAC10 protein, expressed by Sf9 insect cells, with N-GST tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
HDAC10 Protein, Human (Active, sf9, GST) is the recombinant human-derived HDAC10 protein, expressed by Sf9 insect cells, with N-GST tag.
Background
HDAC10 is a polyamine deacetylase (PDAC) that preferentially acts on N(8)-acetylspermidine, as well as acetylcadaverine and acetylputrescine. It exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low or negligible activity toward N(1)-acetylspermidine. In vitro studies have shown histone deacetylase activity and involvement in MSH2 deacetylation, though the physiological relevance of these activities remains unclear and may be minimal. HDAC10 may play a role in promoting late-stage autophagy (e.g., autophagosome-lysosome fusion and/or lysosomal exocytosis) in neuroblastoma cells, as well as in homologous recombination and DNA mismatch repair. by similar: HDAC10 has also been implicated in autophagy and DNA repair processes.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-GST
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Accession
Q969S8-1 (M1-T482)
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Gene ID83933
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Molecular Construction
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N-term
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GST
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(M1-T482)
Accession # Q969S8-1 -
C-term
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Protein Length
Partial
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Synonyms
HDAC10; DKFZP761B039; Histone Deacetylase 10; HD10; Polyamine Deacetylase HDAC10; HDAC10 Protein
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AA Sequence
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAAT
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Predicted Molecular Mass
77 kDa
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Molecular Weight
Approximately 81 kDa, based on SDS-PAGE under reducing conditions.
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Structure/Form
Monomer
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (238 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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