CBP/p300-IN-15
CBP/p300-IN-15 (compound 13a) is a potent p300/CBP inhibitor, with IC50 values of 2.50 and 28.0 nM, respectively. CBP/p300-IN-15 shows good activity against OVCAR-3 and A2780 cell line, with EC50 values of 0.865 and 2.71 μM, respectively. CBP/p300-IN-15 can be used for ovarian cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2379409-91-1
- Formula: C26H28N4O5
- Molecular Weight:476.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
CBP 28 nM (IC50) |
p300 2.5 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | EC50 |
2.71 μM
Compound: 13a
|
Antiproliferative activity against human A2780 cells assessed as inhibition of cell proliferation measured after 120 hrs by Cell-titre glo assay
Antiproliferative activity against human A2780 cells assessed as inhibition of cell proliferation measured after 120 hrs by Cell-titre glo assay
|
[PMID: 34801827] |
| MV4-11 | IC50 |
64.3 nM
Compound: 626; B003
|
Antiproliferative activity against human MV4-11 cells measured after 3 days by celltiter-glo luminescence assay
Antiproliferative activity against human MV4-11 cells measured after 3 days by celltiter-glo luminescence assay
|
[PMID: 31910017] |
| OVCAR-3 | EC50 |
0.865 μM
Compound: 13a
|
Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell proliferation measured after 120 hrs by Cell-titre glo assay
Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell proliferation measured after 120 hrs by Cell-titre glo assay
|
[PMID: 34801827] |
Chemical Information
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CAS No. 2379409-91-1
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Molecular Weight 476.52
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Formula C26H28N4O5
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SMILES
CNC(NC1=CC=C2C(CC[C@@]23OC(N(C3=O)CC(N4CC5=CC=CC=C5CC[C@H]4C)=O)=O)=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)