N,N-Dimethyl-idarubicin
N,N-Dimethyl-idarubicin, an Idarubicin (HY-17381) derivative, is a potent histone evictor which does not induce DNA double-strand breaks. N,N-Dimethyl-idarubicin, an anthracycline, is an effective cytotoxic agent for ABCB1-overexpressing, Doxorubicin-resistant cells.
For research use only. We do not sell to patients.
- CAS No.: 3033865-16-3
- Formula: C28H31NO9
- Molecular Weight:525.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
0.073 μM
Compound: 11
|
Cytotoxicity against human K562 cells overexpressing ABCG2 incubated for 2 hrs followed by compound washout and measured after 72 hrs by Celltiter-blue viability assay
Cytotoxicity against human K562 cells overexpressing ABCG2 incubated for 2 hrs followed by compound washout and measured after 72 hrs by Celltiter-blue viability assay
|
[PMID: 39088428] |
| K562 | IC50 |
0.078 μM
Compound: 11
|
Cytotoxicity against human K562 cells incubated for 2 hrs followed by compound washout and measured after 72 hrs by Celltiter-blue viability assay
Cytotoxicity against human K562 cells incubated for 2 hrs followed by compound washout and measured after 72 hrs by Celltiter-blue viability assay
|
[PMID: 39088428] |
| K562 | IC50 |
0.078 μM
Compound: 18
|
Cytotoxicity against human K562 cells incubated for 2 hrs by cell titre blue viability assay
Cytotoxicity against human K562 cells incubated for 2 hrs by cell titre blue viability assay
|
[PMID: 37561481] |
| K562 | IC50 |
0.091 μM
Compound: 11
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Cytotoxicity against human K562 cells overexpressing ABCB1 incubated for 2 hrs followed by compound washout and measured after 72 hrs by Celltiter-blue viability assay
Cytotoxicity against human K562 cells overexpressing ABCB1 incubated for 2 hrs followed by compound washout and measured after 72 hrs by Celltiter-blue viability assay
|
[PMID: 39088428] |
| MEL-JUSO | IC50 |
0.111 μM
Compound: 18
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Cytotoxicity against human MEL-JUSO cells incubated for 2 hrs by cell titre blue viability assay
Cytotoxicity against human MEL-JUSO cells incubated for 2 hrs by cell titre blue viability assay
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[PMID: 37561481] |
| U2OS | IC50 |
0.118 μM
Compound: 18
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Cytotoxicity against human U2OS cells incubated for 2 hrs by cell titre blue viability assay
Cytotoxicity against human U2OS cells incubated for 2 hrs by cell titre blue viability assay
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[PMID: 37561481] |
Chemical Information
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CAS No. 3033865-16-3
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Molecular Weight 525.55
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Formula C28H31NO9
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SMILES
OC1=C2C(C(C3=CC=CC=C3C2=O)=O)=C(O)C([C@H]4O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)N(C)C)=C1C[C@](O)(C4)C(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N,N-Dimethyl-idarubicin Related Classifications
HY-163918 Related Classifications
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