2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. GK718

GK718 is a HDAC1/3 inhibitor (IC50: 259 and 139 nM respectively). GK718 increased acetylated histone H3 level in cells. GK718 inhibits Bleomycin (HY-108345) induced pulmonary fibrosis in mice.

For research use only. We do not sell to patients.

GK718

GK718 Chemical Structure

CAS No. : 3032392-65-4

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GK718 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

GK718 is a HDAC1/3 inhibitor (IC50: 259 and 139 nM respectively). GK718 increased acetylated histone H3 level in cells. GK718 inhibits Bleomycin (HY-108345) induced pulmonary fibrosis in mice[1].

IC50 & Target

HDAC inhibitor；https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01422 (Compd 21b);新品上线，张雨新分子推荐20231017
Cellular Effect
Cell Line Type Value Description References
A549 IC50
6 μM
Compound: 21b; GK718
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37795958]
SF-268 IC50
3.1 μM
Compound: 21b; GK718
Antiproliferative activity against human SF-268 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human SF-268 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 37795958]
Molecular Weight

517.45

Formula

C26H30Cl2N4O3
CAS No.
SMILES

O=C([C@@H]1NCCC1)NCC2=CC=C(OCC3=CC=C(C(NC4=CC=CC=C4N)=O)C=C3)C=C2.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GK718 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GK7183032392-65-4GK 718GK-718HDACHistone deacetylasesHDAC inhibitionacetylated histone H3pulmonary fibrosisInhibitorinhibitorinhibit

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HY-155329
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