GK718
GK718 is a HDAC1/3 inhibitor (IC50: 259 and 139 nM respectively). GK718 increased acetylated histone H3 level in cells. GK718 inhibits Bleomycin (HY-108345) induced pulmonary fibrosis in mice.
For research use only. We do not sell to patients.
- CAS No.: 3032392-65-4
- Formula: C26H30Cl2N4O3
- Molecular Weight:517.45
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
HDAC inhibitor;https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01422 (Compd 21b);新品上线,张雨新分子推荐20231017
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
6 μM
Compound: 21b; GK718
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 37795958] |
| SF-268 | IC50 |
3.1 μM
Compound: 21b; GK718
|
Antiproliferative activity against human SF-268 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human SF-268 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 37795958] |
Chemical Information
-
CAS No. 3032392-65-4
-
Molecular Weight 517.45
-
Formula C26H30Cl2N4O3
-
SMILES
O=C([C@@H]1NCCC1)NCC2=CC=C(OCC3=CC=C(C(NC4=CC=CC=C4N)=O)C=C3)C=C2.Cl.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)