3032392-65-4
3032392-65-4
Chemical Structure
GK718
- CAS No.: 3032392-65-4
- Formula:C26H30Cl2N4O3
- Molecular Weight:517.45
InChIKey: UFARUDAPUKLDQM-PPLJNSMQSA-N
SMILES: O=C([C@@H]1NCCC1)NCC2=CC=C(OCC3=CC=C(C(NC4=CC=CC=C4N)=O)C=C3)C=C2.Cl.Cl
Biological Activity: GK718 is a HDAC1/3 inhibitor (IC50: 259 and 139 nM respectively). GK718 increased acetylated histone H3 level in cells. GK718 inhibits Bleomycin (HY-108345) induced pulmonary fibrosis in mice[1].
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GK718 | GK718 is a HDAC1/3 inhibitor (IC50: 259 and 139 nM respectively). GK718 increased acetylated histone H3 level in cells. GK718 inhibits Bleomycin (HY-108345) induced pulmonary fibrosis in mice. | |||||||||||||||||||||
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