2. Epigenetics
  3. Epigenetic Reader Domain
  4. BET-IN-18

BET-IN-18 (Compound 3) is a pan-BET bromodomain small-molecule inhibitor, with Ki values of 0.69 μM and 0.37 μM, and Kd values of 1.6 μM and 8.4 μM against BrdT (1) and Brd4 (1) bromodomains, respectively. BET-IN-18 potently and competitively inhibits the binding of the known BET inhibitor (+)-JQ1 (HY-13030) to Brd4 (1) and BrdT (1), with IC50 values of 1.0 μM and 2.3 μM, respectively. BET-IN-18 also competitively inhibits the binding of acetylated histone substrates to Brd4 (1) (IC50 = 0.90 μM). BET-IN-18 can be used in the research of multiple myeloma.

For research use only. We do not sell to patients.

BET-IN-18

BET-IN-18 Chemical Structure

CAS No. : 874594-37-3

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BET-IN-18 Related Antibodies

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Description

BET-IN-18 (Compound 3) is a pan-BET bromodomain small-molecule inhibitor, with Ki values of 0.69 μM and 0.37 μM, and Kd values of 1.6 μM and 8.4 μM against BrdT (1) and Brd4 (1) bromodomains, respectively. BET-IN-18 potently and competitively inhibits the binding of the known BET inhibitor (+)-JQ1 (HY-13030) to Brd4 (1) and BrdT (1), with IC50 values of 1.0 μM and 2.3 μM, respectively. BET-IN-18 also competitively inhibits the binding of acetylated histone substrates to Brd4 (1) (IC50 = 0.90 μM). BET-IN-18 can be used in the research of multiple myeloma[1].

Molecular Weight

339.35

Formula

C18H17N3O4
CAS No.
SMILES

O=C1OCC=2NC3=C(C(=O)NC(=O)N3CC)C(C4=CC=C(C=C4)C)C12
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BET-IN-18 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BET-IN-18874594-37-3Epigenetic Reader DomainBET family bromodomainsBPTFBrd4 bromodomain (Domain 1)acetylated lysine binding sitesacetylated histone substratesBrdT bromodomain (Domain 1)non-BET bromodomainsmultiple myelomaInhibitorinhibitorinhibit

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