HDAC10 Protein, Human (His)
HDAC10 Protein, Human (His) is the recombinant human-derived HDAC10, expressed by E. coli , with N-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
HDAC10 Protein, Human (His) is the recombinant human-derived HDAC10, expressed by E. coli , with N-6*His labeled tag.
HDAC10 is a polyamine deacetylase (PDAC) that preferentially acts on N(8)-acetylspermidine, as well as acetylcadaverine and acetylputrescine. It exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low or negligible activity toward N(1)-acetylspermidine. In vitro studies have shown histone deacetylase activity and involvement in MSH2 deacetylation, though the physiological relevance of these activities remains unclear and may be minimal. HDAC10 may play a role in promoting late-stage autophagy (e.g., autophagosome-lysosome fusion and/or lysosomal exocytosis) in neuroblastoma cells, as well as in homologous recombination and DNA mismatch repair. by similar: HDAC10 has also been implicated in autophagy and DNA repair processes.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
Q969S8-1 (M1-A669)
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Gene ID83933
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Molecular Construction
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N-term
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6*His
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Q969S8-1 HDAC10 (M1-A669)
Accession # -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
HDAC10; DKFZP761B039; Histone Deacetylase 10; HD10; Polyamine Deacetylase HDAC10; HDAC10 Protein
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AA Sequence
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA
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Predicted Molecular Mass
71.4 kDa
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Molecular Weight
Approximately 74 kDa,based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (239 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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