5-Bromo-2,3-dihydro-1H-inden-1-one

Name: 5-Bromo-2,3-dihydro-1H-inden-1-one
Brand: MedChemExpress
SKU: HY-40190
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-40190 Reinheit: 99.95%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

5-Bromo-2,3-dihydro-1H-inden-1-one is an important indanone intermediate that is widely used in the synthesis of anti-tumor indanone derivatives.

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5-Bromo-2,3-dihydro-1H-inden-1-one Chemische Struktur

CAS. Nr. : 34598-49-7

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
25 g	Auf Lager	Estimated Time of Arrival: December 31
50 g	Angebot einholen

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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle HDAC Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

5-Bromo-2,3-dihydro-1H-inden-1-one is an important indanone intermediate that is widely used in the synthesis of anti-tumor indanone derivatives^[1]^[2].

In Vitro

5-Bromo-2,3-dihydro-1H-inden-1-one serves as a starting material in the Heck reaction synthesis of an intermediate used to prepare indeno[1,2-d]thiazole-based HDAC inhibitors^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

211.06

Formel

C₉H₇BrO

CAS. Nr.

34598-49-7

Appearance

Solid

Color

Off-white to yellow

SMILES

O=C1C2=CC=C(Br)C=C2CC1

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (473.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7380 mL	23.6899 mL	47.3799 mL
5 mM	0.9476 mL	4.7380 mL	9.4760 mL
10 mM	0.4738 mL	2.3690 mL	4.7380 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (11.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Reinheit & Dokumentation

Purity: 99.95%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (252 KB) HNMR (110 KB) GC (226 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Xie B, et al. Design, synthesis and evaluation of aurone and indanone derivatives as novel antitumor agents[J]. Medicinal chemistry research, 2024, 33(1): 201-220.

[2]. Zhou M, et al. Design, synthesis and biological evaluation of indeno [1, 2-d] thiazole derivatives as potent histone deacetylase inhibitors[J]. Bioorganic & medicinal chemistry letters, 2013, 23(11): 3200-3203.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7380 mL	23.6899 mL	47.3799 mL	118.4497 mL
	5 mM	0.9476 mL	4.7380 mL	9.4760 mL	23.6899 mL
	10 mM	0.4738 mL	2.3690 mL	4.7380 mL	11.8450 mL
	15 mM	0.3159 mL	1.5793 mL	3.1587 mL	7.8966 mL
	20 mM	0.2369 mL	1.1845 mL	2.3690 mL	5.9225 mL
	25 mM	0.1895 mL	0.9476 mL	1.8952 mL	4.7380 mL
	30 mM	0.1579 mL	0.7897 mL	1.5793 mL	3.9483 mL
	40 mM	0.1184 mL	0.5922 mL	1.1845 mL	2.9612 mL
	50 mM	0.0948 mL	0.4738 mL	0.9476 mL	2.3690 mL
	60 mM	0.0790 mL	0.3948 mL	0.7897 mL	1.9742 mL
	80 mM	0.0592 mL	0.2961 mL	0.5922 mL	1.4806 mL
	100 mM	0.0474 mL	0.2369 mL	0.4738 mL	1.1845 mL