PfPK6-IN-1

PfPK6-IN-1 (Compound 12) exhibits EC₅₀s of 116 nM against Dd2 asexual blood stage parasites and 210 nM against the P. falciparum 3D7 strain^[1].
PfPK6-IN-1 (48 h) is a fast-acting compound active throughout the asexual blood cycle and clears 99.9% of the parasites (99.9% PCT) within 32.5 h^[1].
PfPK6-IN-1 activity is unchanged after PfPK6 knockdown (EC₅₀ of 129 nM in the physiological PK6 levels versus 153 nM in the knockdown) in the Dd2^{PK6 cKD} line^[1].
PfPK6-IN-1 (20-850 nM, 13 months) resists the drug resistance of chloroquine resistant P. falciparum Dd2-B2 strain by targeting the digestive vesicle transport proteins (PfCRT and PfMDR1) of the malaria parasite ^[1].
PfPK6-IN-1 (0-500 nM, 72 h) interaction with chloroquine is antagonistic in 3D7 but synergistic in Dd2^[1].
PfPK6-IN-1 (0-32 h) inhibits hemozoin formation by directly inhibiting the formation of β-hematin in P. falciparum 3D7, and increasing the accumulation of toxic hemoglobin in 3D7 parasites^[1].
PfPK6-IN-1 (0-72 h) is active against Cambodian and Ugandan P. falciparum isolates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.