2417648-94-1
Chemical Structure
PfPK6-IN-1
- CAS 番号: 2417648-94-1
- Formula:C34H41F3N8O2
- Molecular Weight:650.74
IUPAC Name: N-(4-((2-((4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)amino)-1-methyl-1H-benzo[d]imidazol-6-yl)oxy)pyridin-2-yl)-1-methylpiperidine-4-carboxamide
InChIKey: NGRAKOGXFLUUKW-UHFFFAOYSA-N
SMILES: CN1CCC(C(NC2=CC(OC3=CC=C4C(N(C)C(NC5=CC=C(CN6CCN(CC)CC6)C(C(F)(F)F)=C5)=N4)=C3)=CC=N2)=O)CC1
Biological Activity: PfPK6-IN-1 is a potent and selective PfPK6 inhibitor with an IC50 of 0.3 μM. PfPK6-IN-1 inhibits hemozoin formation, a Plasmodium-specific pathway with IC50 of 13 μM against β-hematin (βH). PfPK6-IN-1 exhibits rapid and broad-spectrum anti-malarial properties, being effective against both chloroquine-sensitive and resistant strains.PfPK6-IN-1 can be used for the study of antimalarial[1].
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PfPK6-IN-1 | PfPK6-IN-1 is a potent and selective PfPK6 inhibitor with an IC50 of 0.3 μM. PfPK6-IN-1 inhibits hemozoin formation, a Plasmodium-specific pathway with IC50 of 13 μM against β-hematin (βH). PfPK6-IN-1 exhibits rapid and broad-spectrum anti-malarial properties, being effective against both chloroquine-sensitive and resistant strains.PfPK6-IN-1 can be used for the study of antimalarial. | |||||||||||||||||||||
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Keywords
