SC83288 

SC83288 is a Plasmodium falciparum PfDNMT2 inhibitor with an IC₅₀ of 7 μM. SC83288 disrupts the epigenetic regulation of malaria parasites, blocks DNA replication and nuclear division, arrests the development of the asexual blood stage, induces the formation of pyknotic morphology in malaria parasites, and does not affect cytokinesis after nuclear division or parasite egress. SC83288 is applicable to malaria-related research^[1].

SC83288 (72 h) potently inhibits wild-type P. falciparum 3D7 blood-stage growth with an IC₅₀ of 8 nM, while the PfATP6^F972Y mutant (E4) exhibits high resistance with an IC₅₀ of 5 μM^[1].
SC83288 (100 nM; 15 min) is transported via ATP-dependent mediation by PfATP6, particularly the PfATP6^F972Y mutant, with the mutant showing enhanced transport efficiency that is competed by Ca^2+[1].
SC83288 (50 nM; 0-60 min) is taken up ~100-fold by wild-type 3D7 and E4 mutant P. falciparum-infected erythrocytes via parasite-induced new permeation pathways, with no difference in uptake between the two lines^[1].
SC83288 (30 nM; 0-52 h) blocks DNA replication in wild-type P. falciparum Dd2 and 3D7 blood-stage parasites when added during early ring to trophozoite stages, but has no effect on the E4 (PfATP6^F972Y mutant) line^[1].
SC83288 (5-10 nM; 4.5 h) treatment of P. falciparum 3D7 trophozoites induces transcriptional upregulation of genes linked to epigenetic regulation, karyokinesis, and stress responses^[1].
SC83288 (40 nM; 12 h) disrupts methylation-related metabolism in P. falciparum 3D7 trophozoites, with no effect on the E4 (PfATP6^F972Y mutant) line^[1].
SC83288 (80 nM; 4 h) reduces global RNA m⁶A and DNA m⁵C methylation, and inhibits nuclear DNA methyltransferase activity in P. falciparum trophozoites, with the activity inhibition reversible by SAM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SC83288 (5 mg/kg; daily; 3 consecutive days) cures Plasmodium falciparum infection in humanized NOD/SCID mice, with an in vivo logPRR of 5.3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

629.71

C₂₇H₃₁N₇O₇S₂

1237645-43-0

COC(N1CCN(CC1)C(C2=CC(NC(NC3=CC=C(C=C3)S(=O)(NCC4=CC=C(C=C4)S(N)(=O)=O)=O)=O)=CC=C2)=N)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sanchez CP, et al. Mechanisms of PfDNMT2 inhibition and PfATP6-mediated resistance to the antimalarial candidate SC83288 in Plasmodium falciparum. Nat Commun. 2026;17(1):2327. Published 2026 Mar 6.