1237645-43-0
Chemical Structure
SC83288
- CAS No.: 1237645-43-0
- Formula:C27H31N7O7S2
- Molecular Weight:629.71
InChIKey: UJKWTQWUYKHLGQ-UHFFFAOYSA-N
SMILES: COC(N1CCN(CC1)C(C2=CC(NC(NC3=CC=C(C=C3)S(=O)(NCC4=CC=C(C=C4)S(N)(=O)=O)=O)=O)=CC=C2)=N)=O
Biological Activity: SC83288 is a Plasmodium falciparum PfDNMT2 inhibitor with an IC50 of 7 μM. SC83288 disrupts the epigenetic regulation of malaria parasites, blocks DNA replication and nuclear division, arrests the development of the asexual blood stage, induces the formation of pyknotic morphology in malaria parasites, and does not affect cytokinesis after nuclear division or parasite egress. SC83288 is applicable to malaria-related research[1].
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SC83288 | SC83288 is a Plasmodium falciparum PfDNMT2 inhibitor with an IC50 of 7 μM. SC83288 disrupts the epigenetic regulation of malaria parasites, blocks DNA replication and nuclear division, arrests the development of the asexual blood stage, induces the formation of pyknotic morphology in malaria parasites, and does not affect cytokinesis after nuclear division or parasite egress. SC83288 is applicable to malaria-related research. | |||||||||||||||||||||
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Keywords
