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  3. SGC-iMLLT

SGC-iMLLT 

Cat. No.: HY-112804
Handling Instructions

SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interactions, occupies the Kac/Kcr binding site of MLLT1 YD (ENL/YEATS1), with high binding activity at MLLT1 YD (IC50, 0.26 μM; Kd, 0.129 μM) and MLLT3 YD (AF9/YEATS3) (Kd, 0.077 μM).

For research use only. We do not sell to patients.

SGC-iMLLT Chemical Structure

SGC-iMLLT Chemical Structure

CAS No. : 2255338-25-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 605 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interactions, occupies the Kac/Kcr binding site of MLLT1 YD (ENL/YEATS1), with high binding activity at MLLT1 YD (IC50, 0.26 μM; Kd, 0.129 μM) and MLLT3 YD (AF9/YEATS3) (Kd, 0.077 μM)[1].

IC50 & Target

IC50: 0.26 μM (MLLT1 YD)[1]
Kd: 0.077 μM (MLLT3 YD), 0.129 μM (MLLT1 YD)[1]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (214.51 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5742 mL 12.8710 mL 25.7420 mL
5 mM 0.5148 mL 2.5742 mL 5.1484 mL
10 mM 0.2574 mL 1.2871 mL 2.5742 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.35 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (5.35 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.35 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

388.47

Formula

C₂₂H₂₄N₆O

CAS No.

2255338-25-9

SMILES

CN1N=CC2=CC(C(NC3=CC=C(NC(CN4[[email protected]@H](C)CCC4)=N5)C5=C3)=O)=CC=C21

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
SGC-iMLLT
Cat. No.:
HY-112804
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SGC-iMLLT

Cat. No.: HY-112804