2255338-25-9
2255338-25-9
Chemical Structure
SGC-iMLLT
- CAS No.: 2255338-25-9
- Formula:C22H24N6O
- Molecular Weight:388.47
IUPAC Name: (S)-1-methyl-N-(2-((2-methylpyrrolidin-1-yl)methyl)-1H-benzo[d]imidazol-5-yl)-1H-indazole-5-carboxamide
InChIKey: QGNDVASWIHEXCL-AWEZNQCLSA-N
SMILES: CN1N=CC2=CC(C(NC3=CC=C(NC(CN4[C@@H](C)CCC4)=N5)C5=C3)=O)=CC=C21
Biological Activity: SGC-iMLLT is a first-in-class chemical probe and a potent, selective inhibitor of MLLT1/3-histone interactions with an IC50 of 0.26 μM. SGC-iMLLT shows high binding activity towards MLLT1 YEATS domain (YD) and MLLT3 YD (AF9/YEATS3) with Kds of 0.129 and 0.077 μM, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SGC-iMLLT | 99.38% | SGC-iMLLT is a first-in-class chemical probe and a potent, selective inhibitor of MLLT1/3-histone interactions with an IC50 of 0.26 μM. SGC-iMLLT shows high binding activity towards MLLT1 YEATS domain (YD) and MLLT3 YD (AF9/YEATS3) with Kds of 0.129 and 0.077 μM, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.76
HY-152469Eleven-Nineteen-Leukemia Protein IN-1 -
Similarity Score 0.73
HY-160287NVS MLLT-1 -
Similarity Score 0.73
HY-152470Eleven-Nineteen-Leukemia Protein IN-2 -
Similarity Score 0.70
HY-152471Eleven-Nineteen-Leukemia Protein IN-3 -
Similarity Score 0.69
HY-162350TDI-11055 -
Similarity Score 0.59
HY-116097PSB-1491 -
Similarity Score 0.57
HY-129224XS018661 -
Similarity Score 0.55
HY-114178CDK8-IN-2 -
Similarity Score 0.52
HY-158681PARP1-IN-22 -
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