Eleven-Nineteen-Leukemia Protein IN-2
Eleven-Nineteen-Leukemia Protein IN-2 (compound 23) is an Eleven-Nineteen-Leukemia Protein (ENL) inhibitor with an IC50 value of 10.7 nM. Eleven-Nineteen-Leukemia Protein IN-2 can be used for the research of leukemia.
For research use only. We do not sell to patients.
- CAS No.: 2894121-78-7
- Formula: C22H23N5O2
- Molecular Weight:389.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | IC50 |
37.9 μM
Compound: 23
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Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth measured after 72 hrs by Cell Titer-Glo luminescent assay
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth measured after 72 hrs by Cell Titer-Glo luminescent assay
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[PMID: 36645983] |
| MV4-11 | IC50 |
51.4 μM
Compound: 23
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Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth measured after 72 hrs by Cell Titer-Glo luminescent assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth measured after 72 hrs by Cell Titer-Glo luminescent assay
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[PMID: 36645983] |
In Vitro
Eleven-Nineteen-Leukemia Protein IN-2 (0-1000 nM) shows ENL inhibitory activity with an IC50 value of 10.7 nM[1]. Eleven-Nineteen-Leukemia Protein IN-2 (0-1000 μM; 72 hours) inhibits activity of MOLM-13 cells with an IC50 value of 37.9 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2894121-78-7
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Molecular Weight 389.45
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Formula C22H23N5O2
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SMILES
CC1=NOC2=CC(C(NC3=CC=C4NC(CN5CCC[C@@H]5C)=NC4=C3)=O)=CC=C21
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Eleven-Nineteen-Leukemia Protein IN-2 Related Classifications
HY-152470 Related Classifications
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