Eleven-Nineteen-Leukemia Protein IN-1
Eleven-Nineteen-Leukemia Protein IN-1 is an inhibitor of ENL YEATS domain with an IC50 value of 14.5 nM. Eleven-Nineteen-Leukemia Protein IN-1 interacts with ENL protein and enhances the thermal stability of ENL protein in vitro.
For research use only. We do not sell to patients.
- CAS No.: 2894121-68-5
- Formula: C27H33N7O2
- Molecular Weight:487.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Eleven-Nineteen-Leukemia YEATS domain 14.5 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| MOLM-13 | IC50 |
39.6 μM
Compound: 13
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Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth measured after 72 hrs by Cell Titer-Glo luminescent assay
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth measured after 72 hrs by Cell Titer-Glo luminescent assay
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[PMID: 36645983] |
In Vitro
Eleven-Nineteen-Leukemia Protein IN-1 (compound 13) has inhibition on MOLM-13 cells and MV4-11 cells with IC50 values of 39.6 µM, 45.1 µM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2894121-68-5
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Molecular Weight 487.60
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Formula C27H33N7O2
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SMILES
C[C@H]1CCCN1CC2=NC3=CC(NC(C4=CC5=C(N(N=C5)CCN6CCOCC6)C=C4)=O)=CC=C3N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Eleven-Nineteen-Leukemia Protein IN-1 Related Classifications
HY-152469 Related Classifications
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