Norcaesalpinin E

Cat. No.: HY-N7583 Purity: 93%: Data Sheet
COA

SDS
Handling Instructions
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Norcaesalpinin E, a C-17-norcassane-type diterpene found in Caesalpinia crista, is a Plasmodium falciparum growth inhibitor with an IC₅₀ of 90 nM. Norcaesalpinin E induces dose-dependent growth inhibition of Plasmodium falciparum. Norcaesalpinin E can be used for the research of malaria.

For research use only. We do not sell to patients.

Norcaesalpinin E Chemical Structure

CAS No. : 854038-96-3

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1 mg	In-stock	Estimated Time of Arrival: December 31
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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Plasmodium

90 nM (IC₅₀)

In Vitro

Norcaesalpinin E (72 h) potently inhibits the growth of Plasmodium falciparum FCR-3/A2 clone in vitro with an IC₅₀ of 90 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

376.44

Formula

C₂₁H₂₈O₆

CAS No.

854038-96-3

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]([C@@](C[C@@H]1O)(C2(C)C)O)([C@H](CC2)OC(C)=O)[C@](CC3=C4C=CO3)([H])[C@]1([H])C4=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 93%

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Data Sheet (286 KB) SDS (251 KB)

COA (259 KB)

Handling Instructions (2659 KB)

References

[1]. Kalauni SK, et al. Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship. Biol Pharm Bull. 2006;29(5):1050-1052.

[2]. Linn TZ, et al. Cassane- and norcassane-type diterpenes from Caesalpinia crista of Indonesia and their antimalarial activity against the growth of Plasmodium falciparum. J Nat Prod. 2005;68(5):706-710. [Content Brief]