1. Epigenetics
    Others
    Apoptosis
  2. Histone Demethylase
    Estrogen Receptor/ERR
    Apoptosis
  3. LSD1/ER-IN-1

LSD1/ER-IN-1 

Cat. No.: HY-146440
Handling Instructions

LSD1/ER-IN-1 (compound 11g) is a potent ER and LSD1 inhibitor, with an IC50 of 1.55 μM (LSD1). LSD1/ER-IN-1 has high affinity selectivity for ERα protein, with α/β ratio of 7.11. LSD1/ER-IN-1 shows good antiproliferative activity against MCF-7 breast cancer cells, with an IC50 of 8.79 μM.

For research use only. We do not sell to patients.

LSD1/ER-IN-1 Chemical Structure

LSD1/ER-IN-1 Chemical Structure

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Description

LSD1/ER-IN-1 (compound 11g) is a potent ER and LSD1 inhibitor, with an IC50 of 1.55 μM (LSD1). LSD1/ER-IN-1 has high affinity selectivity for ERα protein, with α/β ratio of 7.11. LSD1/ER-IN-1 shows good antiproliferative activity against MCF-7 breast cancer cells, with an IC50 of 8.79 μM[1].

IC50 & Target

ERα

 

ERβ

 

In Vitro

LSD1/ER-IN-1 (compound 11g) (0-30 μM, 24 h) induces apoptosis in MCF-7 cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

455.46

Formula

C23H18FNO6S

SMILES

O=S([[email protected]]1C[[email protected]@H]2C(C3=CC=C(C=C3)O)=C([[email protected]]1O2)C4=CC=C(C=C4)O)(OC5=NC(F)=CC=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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LSD1/ER-IN-1
Cat. No.:
HY-146440
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