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Cat. No.: HY-P83151

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SETD7 Antibody (YA2896)

Name: SETD7 Antibody (YA2896)
Brand: MedChemExpress
SKU: HY-P83151
Price: 146.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Histone H3-K4 methyltransferase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7; SET9)

Customer Review

Based on 1 Customer Validation

SETD7 Antibody (YA2896) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SETD7.

For research use only. We do not sell to patients.

Host:
Rabbit
Isotype:
IgG
Application:
WB, IP
Reactivity :
Human, Mouse, Rat

Formulation:
Supplied in rabbit IgG in PBS(pH 7.4), 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Conjugation:
Non-conjugated

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Concentration
- Storage & Stability
- Shipping
Background
Documentation
References
Help & FAQs
Classifications
Bioz

Applications

Application	WB WB: Western Blot	IP IP: Immunoprecipitation
Dilution Ratio	1:1000-1:2000	1:50

Product Details

Description

SETD7 Antibody (YA2896) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SETD7.

Host Rabbit
Clonality Recombinant,Monoclonal
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 41 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 41 kDa

Species Reactivity Database

Entrez Gene: 80854 Human ; 73251 Mouse ; 689954 Rat

SwissProt: Q8WTS6 Human ; Q8VHL1 Mouse ;

OMIM: 606594 Human

Immunogen

A synthesized peptide derived from human SETD7 aa1-30.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

Appearance

Solution
Formulation

Supplied in rabbit IgG in PBS(pH 7.4), 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Concentration

Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

SETD7 is a Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9]^[10].
Subcellular Localization

Nucleus; Chromosome
Expression

Tissue_specificity:Widely expressed. Expressed in the pancreatic islets.
Subunit

Interacts with IPF1/PDX-1
SwissProt ID

Q8WTS6
Gene ID

80854 [NCBI]
Synonyms

Histone H3-K4 methyltransferase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7; SET9
Research Field

Epigenetics and Nuclear Signaling

Documentation

Select Batch:

Data Sheet (261 KB)
SDS (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
User Guide for Antibodies (1077 KB)

References

[1]. Wang H, et al. Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol Cell. 2001 Dec;8(6):1207-17. [Content Brief]

[2]. Nishioka K, et al. Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev. 2002 Feb 15;16(4):479-89. [Content Brief]

[3]. Xiao B, et al. Structure and catalytic mechanism of the human histone methyltransferase SET7/9. Nature. 2003 Feb 6;421(6923):652-6. [Content Brief]

[4]. Martens JH, et al. Cascade of distinct histone modifications during collagenase gene activation. Mol Cell Biol. 2003 Mar;23(5):1808-16. [Content Brief]

[5]. Francis J, et al. Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription. J Biol Chem. 2005 Oct 28;280(43):36244-53. [Content Brief]

[6]. Kouskouti A, et al. Gene-specific modulation of TAF10 function by SET9-mediated methylation. Mol Cell. 2004 Apr 23;14(2):175-82. [Content Brief]

[7]. Chuikov S, et al. Regulation of p53 activity through lysine methylation. Nature. 2004 Nov 18;432(7015):353-60. [Content Brief]

[8]. Couture JF, et al. Structural basis for the methylation site specificity of SET7/9. Nat Struct Mol Biol. 2006 Feb;13(2):140-6. [Content Brief]

[9]. Xiao Y, et al. RIOX1-demethylated cGAS regulates ionizing radiation-elicited DNA repair. Bone Res. 2022 Feb 24;10(1):19. [Content Brief]

[10]. Huang J, et al. Repression of p53 activity by Smyd2-mediated methylation. Nature. 2006 Nov 30;444(7119):629-32. [Content Brief]