SETD7 - SET domain containing 7, histone lysine methyltransferase Gene

Also Known as KMT7; SET7; SET9; SET7/9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80854

About SETD7

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:139,492,974-139,556,219 (from NCBI)

This gene has 7 transcripts (splice variants), 194 orthologues and 7 paralogues. Ubiquitous expression in fat (RPKM 22.9), prostate (RPKM 16.7) and 24 other tissues.

Summary

Enables histone-lysine N-methyltransferase activity and p53 binding activity. Involved in peptidyl-lysine dimethylation and peptidyl-lysine monomethylation. Acts upstream of or within cellular response to DNA damage stimulus and heterochromatin organization. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

SETD7 Products (3)

mRNA Protein Name
NM_001306199.2 NP_001293128.1 histone-lysine N-methyltransferase SETD7 isoform 2
NM_001306200.2 NP_001293129.1 histone-lysine N-methyltransferase SETD7 isoform 3
NM_030648.4 NP_085151.1 histone-lysine N-methyltransferase SETD7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables histone H3 methyltransferase activity IDA
IDA: Inferred from direct assay
16415881 GOA
enables histone methyltransferase activity IDA
IDA: Inferred from direct assay
17707234 GOA
enables p53 binding IPI
IPI: Inferred from physical interaction
17108971 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12540855 GOA
enables protein-lysine N-methyltransferase activity IDA
IDA: Inferred from direct assay
16415881 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
23509280 GOA
acts upstream of or within heterochromatin organization IDA
IDA: Inferred from direct assay
23509280 GOA
involved in peptidyl-lysine dimethylation IDA
IDA: Inferred from direct assay
17108971 GOA
involved in peptidyl-lysine monomethylation IDA
IDA: Inferred from direct assay
17108971 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SETD7 Protein Structure

MORN

MORN: MORN repeat (19 - 34)

MORN

MORN: MORN repeat (36 - 58)

MORN

MORN: MORN repeat (60 - 81)

MORN

MORN: MORN repeat (106 - 127)

SET

SET: SET domain (229 - 336)

  • 0
  • 100
  • 200
  • 300
  • 366 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SETD7

  • H3-K4-HMTase SETD7

SETD7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SETD7 Q8WTS6 SIRT1 Homo sapiens Q96EB6
Methyltransferase Ass
21245319
Intra
SETD7 Q8WTS6 SIRT1 Homo sapiens Q96EB6
Pull Down
21245319
Intra
SETD7 Q8WTS6 SIRT1 Homo sapiens Q96EB6
Anti Tag CoIP
21245319
Intra
SETD7 Q8WTS6 TP53 Homo sapiens P04637
Radiolabeled Methyl
16415881
Intra
SETD7 Q8WTS6 TP53 Homo sapiens P04637
Methyltransferase Ass
17805299
Intra
SETD7 Q8WTS6 TP53 Homo sapiens P04637
Methyltransferase Ass
21245319
Intra
SETD7 Q8WTS6 TP53 Homo sapiens P04637
Pull Down
21245319
Intra
SETD7 Q8WTS6 RB1 Homo sapiens P06400
Methyltransferase Ass
21119616
Intra
SETD7 Q8WTS6 TAF10 Homo sapiens Q12962
X-Ray Diffraction
16415881
Intra
SETD7 Q8WTS6 TAF10 Homo sapiens Q12962
Radiolabeled Methyl
16415881
Intra
SETD7 Q8WTS6 DNMT1 Homo sapiens P26358
Methyltransferase Ass
19282482
Intra
SETD7 Q8WTS6 DNMT1 Homo sapiens P26358
Pull Down
19282482
Intra
SETD7 Q8WTS6 RELA Homo sapiens Q04206
Methyltransferase Ass
19262565
Intra
SETD7 Q8WTS6 RELA Homo sapiens Q04206
Anti Tag CoIP
19262565
Intra
SETD7 Q8WTS6 RELA Homo sapiens Q04206
Pull Down
19262565
Intra
SETD7 Q8WTS6 RELA Homo sapiens Q04206
Anti Bait CoIP
19262565
Intra
SETD7 Q8WTS6 SERTAD1 Homo sapiens Q9UHV2
Y2H
21988832
Intra
SETD7 Q8WTS6 H3C1 Homo sapiens P68431
X-Ray Diffraction
12540855
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SETD7 Proteins

Cat. No. Product Name Accession Purity
HY-P76062 SETD7 Protein, Human (His) Q8WTS6/NP_085151.1 (D2-K366) ≥ 95%, as determined by Bis-Tris PAGE.

SETD7 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83151 SETD7 Antibody (YA2896) WB, IP Human, Mouse, Rat
HY-P84685 SETD7 Antibody (YA4382) WB, FC, ELISA Human, Rat, Monkey
HY-P84685A SETD7 Antibody (YA4382)(PBS only) WB, FC, ELISA Human, Rat, Monkey
HY-P84686 SETD7 Antibody (YA4383) WB, IHC-P, ELISA Human, Rat, Monkey
HY-P84686A SETD7 Antibody (YA4383)(PBS only) WB, IHC-P, ELISA Human, Rat, Monkey

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18627A PFI-2 hydrochloride Inhibitor 99.48% Unkown
HY-13807 UNC0646 Inhibitor 99.38% Unkown
HY-18627 PFI-2 Inhibitor 99.68% Unkown
HY-110196 (S)-PFI-2 hydrochloride Inhibitor / Unkown
HY-119164 DC-S238 Inhibitor / Unkown
HY-156455 SETD7-IN-1 Inhibitor / Unkown
HY-182676 DC541 Inhibitor / Unkown
HY-RS12747 SETD7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18842 Setd7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25334 Setd7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SETD7 VGNC VGNC:46058
Rattus norvegicus SETD7 RGD RGD:1586346
Mus musculus SETD7 MGD MGI:1920501
Bos taurus SETD7 VGNC VGNC:34497
Felis catus SETD7 VGNC VGNC:65046
Macaca mulatta SETD7 VGNC VGNC:77348
Others SETD7 NCBI