2. Gene
  3. SETD7 - SET domain containing 7, histone lysine methyltransferase Gene

SETD7 - SET domain containing 7, histone lysine methyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as KMT7; SET7; SET9; SET7/9

Gene ID: 80854 | Gene type: protein coding

About SETD7

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:139,492,974-139,556,219 (from NCBI)

This gene has 7 transcripts (splice variants), 194 orthologues and 7 paralogues. Ubiquitous expression in fat (RPKM 22.9), prostate (RPKM 16.7) and 24 other tissues.

Summary

Enables histone-lysine N-methyltransferase activity and p53 binding activity. Involved in peptidyl-lysine dimethylation and peptidyl-lysine monomethylation. Acts upstream of or within cellular response to DNA damage stimulus and heterochromatin organization. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

SETD7 Products(3)

mRNA Protein Name
NM_001306199.2 NP_001293128.1 histone-lysine N-methyltransferase SETD7 isoform 2
NM_001306200.2 NP_001293129.1 histone-lysine N-methyltransferase SETD7 isoform 3
NM_030648.4 NP_085151.1 histone-lysine N-methyltransferase SETD7 isoform 1

SETD7 Protein Structure

MORN

MORN: MORN repeat (19 - 34)

MORN

MORN: MORN repeat (36 - 58)

MORN

MORN: MORN repeat (60 - 81)

MORN

MORN: MORN repeat (106 - 127)

SET

SET: SET domain (229 - 336)

  • 0
  • 100
  • 200
  • 300
  • 366 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SETD7

H3-K4-HMTase SETD7

Recombinant SETD7 Proteins

Cat. No. Product Name Accession Purity
HY-P76062 SETD7 Protein, Human (His) Q8WTS6/NP_085151.1 (D2-K366) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18627A PFI-2 hydrochloride Inhibitor 99.52% Unkown
HY-13807 UNC0646 Inhibitor 99.82% Unkown
HY-148817 WDR5-0102 Inhibitor 97.02% Unkown
HY-18627 PFI-2 Inhibitor / Unkown
HY-110196 (S)-PFI-2 hydrochloride / Unkown
HY-156455 SETD7-IN-1 Inhibitor / Unkown
HY-RS12747 SETD7 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SETD7 VGNC VGNC:46058
Rattus norvegicus SETD7 RGD RGD:1586346
Mus musculus SETD7 MGD MGI:1920501
Bos taurus SETD7 VGNC VGNC:34497
Felis catus SETD7 VGNC VGNC:65046
Macaca mulatta SETD7 VGNC VGNC:77348
Others SETD7 NCBI