1. Epigenetics
  2. Histone Demethylase
  3. KDM2A/7A-IN-1

KDM2A/7A-IN-1 

Cat. No.: HY-108706
Handling Instructions

KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases.

For research use only. We do not sell to patients.

KDM2A/7A-IN-1 Chemical Structure

KDM2A/7A-IN-1 Chemical Structure

CAS No. : 2169272-46-0

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Description

KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases[1].

IC50 & Target

IC50: 0.16 μM (KDM2A)[1]

In Vitro

KDM2A/7A-IN-1 ((S,S)-6) is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive to methyl transferases, and histone acetyl transferases[1].
KDM2A/7A-IN-1 (0.4, 3.1, 6.2 μM) augments cellular H3K36me2 levels in HeLa cells ectopically expressing catalytically active KDM2A[1].

Molecular Weight

506.68

Formula

C₃₃H₃₈N₄O

CAS No.

2169272-46-0

SMILES

CC(N([[email protected]@H](C1=CN=CC(CCCCCCCN2CCCC2)=C1)[[email protected]@]3(C4=CC=CC=C4)C#N)C5=C3C=CC=C5)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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