2169272-46-0
2169272-46-0
Chemical Structure
KDM2A/7A-IN-1
- CAS No.: 2169272-46-0
- Formula:C33H38N4O
- Molecular Weight:506.68
IUPAC Name: (2S,3S)-1-acetyl-3-phenyl-2-(5-(7-(pyrrolidin-1-yl)heptyl)pyridin-3-yl)indoline-3-carbonitrile
InChIKey: VJAWJBZGYNKPQV-JHOUSYSJSA-N
SMILES: CC(N([C@@H](C1=CN=CC(CCCCCCCN2CCCC2)=C1)[C@@]3(C4=CC=CC=C4)C#N)C5=C3C=CC=C5)=O
Biological Activity: KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KDM2A/7A-IN-1 | 99.94% | KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16 μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases. | ||||||||||||||||||||
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KdM2A/7A-IN-1 (Standard) | ≥98% | KdM2A/7A-IN-1 (Standard) is the analytical standard of KdM2A/7A-IN-1 (HY-108706). This product is intended for research and analytical applications. KdM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KdM2A/7A, with an IC50 of 0.16 μM for KdM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases. | ||||||||||||||||||||
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References
