Trichostatin C 

Trichostatin C is an inhibitor for histone deacetylase (HDAC), induces apoptosis and arrests cell cycle at G2/M phase, and exhibits anticancer activity against lung cancer and urothelial bladder cancer^[1]. Trichostatin C induces differentation of Friend leukemic cells^[2]. Trichostatin C exhibits antifungal activity^[3].

Trichostatin C (0-100 μM) exhibits inhibitory activity against HDAC1 and HDAC6, inhibits proliferations of cancer cells A549, J82 and SK-BR-3, with IC₅₀s of 6.24, 4.16 and 0.6 μM, respectively^[1].
Trichostatin C (0-10 μM) induces apoptosis in cells J82 through activation of caspase 3 and caspase 7^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

464.51

C₂₃H₃₂N₂O₈

68676-88-0

O=C(NO[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O)/C=C/C(C)=C/[C@@H](C)C(C2=CC=C(N(C)C)C=C2)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang C, et al., Trichostatin C Synergistically Interacts with DNMT Inhibitor to Induce Antineoplastic Effect via Inhibition of Axl in Bladder and Lung Cancer Cells[J]. Pharmaceuticals, 2024, 17(4): 425.

  [2]. Yoshida M, et al., Trichostatin C, a new inducer of differentiation of Friend leukemic cells[J]. Agricultural and biological chemistry, 1985, 49(2): 563-565.

  [3]. Tsuji N, et al., a glucopyranosyl hydroxamate. J Antibiot (Tokyo). 1978 Oct;31(10):939-44.  [Content Brief]