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Cat. No.: HY-145813

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MU1656

MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC₅₀ of 2 nM. MU1656 can be used for the research of hematological malignancies.

For research use only. We do not sell to patients.

CAS No.: 2766698-38-6
Formula: C₃₂H₄₅N₇O₂
Molecular Weight:559.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

MU1656 Chemical Structure

CAS No.: 2766698-38-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC₅₀ of 2 nM. MU1656 can be used for the research of hematological malignancies^[1].

IC₅₀ & Target

^[1]

DOT1L

2 nM (IC₅₀)

All Histone Methyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MOLM-13	EC₅₀	7.7 μM Compound: (-)-53; MU1656	Cytotoxicity against human MOLM-13 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human MOLM-13 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
MV4-11	EC₅₀	1.7 μM Compound: (-)-53; MU1656	Cytotoxicity against human MV4-11 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human MV4-11 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
SK-N-MC	EC₅₀	8.8 μM Compound: (-)-53; MU1656	Cytotoxicity against human SK-N-MC cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human SK-N-MC cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
SU-DHL-5	EC₅₀	9 μM Compound: (-)-53; MU1656	Cytotoxicity against human SU-DHL-5 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human SU-DHL-5 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]

Chemical Information

CAS No. 2766698-38-6
Molecular Weight 559.75
Formula C₃₂H₄₅N₇O₂
SMILES

O[C@H]1[C@@H](C[C@@H]([C@H]1O)CN([C@H]2C[C@H](C2)CCC(NC3=C4)=NC3=CC=C4C(C)(C)C)C(C)C)C5=CC=C6N5N=CN=C6N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Khirsariya P, et, al. Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides. J Med Chem. 2022 Apr 14;65(7):5701-5723. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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