country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-145813

Copy Link Print Information

MU1656

MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC₅₀ of 2 nM. MU1656 can be used for the research of hematological malignancies.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2766698-38-6
Formule: C₃₂H₄₅N₇O₂
Masse moléculaire:559.75

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

MU1656 Chemical Structure

CAS No.: 2766698-38-6

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC₅₀ of 2 nM. MU1656 can be used for the research of hematological malignancies^[1].

IC₅₀ & Target^[1]

DOT1L

2 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

Cellular Effect

Cell Line	Type	Value	Description	References
MOLM-13	EC₅₀	7.7 μM Compound: (-)-53; MU1656	Cytotoxicity against human MOLM-13 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human MOLM-13 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
MV4-11	EC₅₀	1.7 μM Compound: (-)-53; MU1656	Cytotoxicity against human MV4-11 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human MV4-11 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
SK-N-MC	EC₅₀	8.8 μM Compound: (-)-53; MU1656	Cytotoxicity against human SK-N-MC cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human SK-N-MC cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
SU-DHL-5	EC₅₀	9 μM Compound: (-)-53; MU1656	Cytotoxicity against human SU-DHL-5 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human SU-DHL-5 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]

Chemical Information

CAS No. 2766698-38-6
Masse moléculaire 559.75
Formule C₃₂H₄₅N₇O₂
SMILES

O[C@H]1[C@@H](C[C@@H]([C@H]1O)CN([C@H]2C[C@H](C2)CCC(NC3=C4)=NC3=CC=C4C(C)(C)C)C(C)C)C5=CC=C6N5N=CN=C6N
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Khirsariya P, et, al. Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides. J Med Chem. 2022 Apr 14;65(7):5701-5723. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

MU1656

Voir tous les produits spécifiques à Isoform Histone Methyltransferase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

MU1656 Related Classifications

HY-145813 Related Classifications