MU1656
MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC50 of 2 nM. MU1656 can be used for the research of hematological malignancies.
For research use only. We do not sell to patients.
- CAS No.: 2766698-38-6
- Formula: C32H45N7O2
- Molecular Weight:559.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
More
Biological Activity
|
DOT1L |
DOT1L 2 nM (IC50) |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MOLM-13 | EC50 |
7.7 μM
Compound: (-)-53; MU1656
|
Cytotoxicity against human MOLM-13 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay
Cytotoxicity against human MOLM-13 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay
|
[PMID: 35302777] |
| MV4-11 | EC50 |
1.7 μM
Compound: (-)-53; MU1656
|
Cytotoxicity against human MV4-11 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay
Cytotoxicity against human MV4-11 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay
|
[PMID: 35302777] |
| SK-N-MC | EC50 |
8.8 μM
Compound: (-)-53; MU1656
|
Cytotoxicity against human SK-N-MC cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay
Cytotoxicity against human SK-N-MC cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay
|
[PMID: 35302777] |
| SU-DHL-5 | EC50 |
9 μM
Compound: (-)-53; MU1656
|
Cytotoxicity against human SU-DHL-5 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay
Cytotoxicity against human SU-DHL-5 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay
|
[PMID: 35302777] |
Chemical Information
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CAS No. 2766698-38-6
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Molecular Weight 559.75
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Formula C32H45N7O2
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SMILES
O[C@H]1[C@@H](C[C@@H]([C@H]1O)CN([C@H]2C[C@H](C2)CCC(NC3=C4)=NC3=CC=C4C(C)(C)C)C(C)C)C5=CC=C6N5N=CN=C6N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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