1. Cell Cycle/DNA Damage
    Epigenetics
    Protein Tyrosine Kinase/RTK
  2. Aurora Kinase
    PDGFR
    RET
    VEGFR
  3. Ilorasertib hydrochloride

Ilorasertib hydrochloride (Synonyms: ABT-348 hydrochloride)

Cat. No.: HY-16018A
Handling Instructions

Ilorasertib hydrochloride (ABT-348 hydrochloride) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. Ilorasertib hydrochloride (ABT-348 hydrochloride) also suppresses RET tyrosine kinase, PDGFRβ and Flt1 with IC50s of 7 nM, 3 nM and 32 nM, respectively.

For research use only. We do not sell to patients.

Ilorasertib hydrochloride Chemical Structure

Ilorasertib hydrochloride Chemical Structure

CAS No. : 1847485-91-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 127 In-stock
Estimated Time of Arrival: December 31
1 mg USD 70 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Ilorasertib hydrochloride:

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Description

Ilorasertib hydrochloride (ABT-348 hydrochloride) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. Ilorasertib hydrochloride (ABT-348 hydrochloride) also suppresses RET tyrosine kinase, PDGFRβ and Flt1 with IC50s of 7 nM, 3 nM and 32 nM, respectively[1].

IC50 & Target

Aurora C

1 nM (IC50)

Aurora B

7 nM (IC50)

Aurora B (Y156H)

12 nM (IC50)

Aurora A

120 nM (IC50)

PDGFRα

11 nM (IC50)

PDGFRβ

13 nM (IC50)

VEGFR1

1 nM (IC50)

VEGFR2

2 nM (IC50)

VEGFR3

43 nM (IC50)

FLT3

1 nM (IC50)

CSF-1R

3 nM (IC50)

c-KIT

20 nM (IC50)

Molecular Weight

525.00

Formula

C₂₅H₂₂ClFN₆O₂S

CAS No.

1847485-91-9

SMILES

O=C(NC1=CC=CC(F)=C1)NC2=CC=C(C3=CSC4=C3C(N)=NC=C4C5=CN(CCO)N=C5)C=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (79.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9048 mL 9.5238 mL 19.0476 mL
5 mM 0.3810 mL 1.9048 mL 3.8095 mL
10 mM 0.1905 mL 0.9524 mL 1.9048 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.96 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.96 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Ilorasertib hydrochloride
Cat. No.:
HY-16018A
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