1. Epigenetics
  2. Histone Acetyltransferase
  3. Histone Acetyltransferase Inhibitor II

Histone Acetyltransferase Inhibitor II 

Cat. No.: HY-100734 Purity: 99.11%
Handling Instructions

Histone Acetyltransferase Inhibitor II (compound 2c) is a potent, selective and cell permeable p300 histone acetyltransferase inhibitor, with an IC50 of 5 µM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells.

For research use only. We do not sell to patients.

Histone Acetyltransferase Inhibitor II Chemical Structure

Histone Acetyltransferase Inhibitor II Chemical Structure

CAS No. : 932749-62-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
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25 mg USD 264 In-stock
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50 mg USD 456 In-stock
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100 mg USD 780 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Histone Acetyltransferase Inhibitor II (compound 2c) is a potent, selective and cell permeable p300 histone acetyltransferase inhibitor, with an IC50 of 5 µM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells[1].

IC50 & Target[1]

p300

5 μM (IC50)

In Vitro

Histone Acetyltransferase Inhibitor II (20-40 μM) decreases the levels of H3 acetylation in HeLa-H2B-EYFP cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

464.15

Formula

C₂₀H₁₆Br₂O₃

CAS No.

932749-62-7

SMILES

O=C1/C(CCC/C1=C\C2=CC=C(O)C(Br)=C2)=C/C3=CC=C(O)C(Br)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (64.63 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1545 mL 10.7724 mL 21.5448 mL
5 mM 0.4309 mL 2.1545 mL 4.3090 mL
10 mM 0.2154 mL 1.0772 mL 2.1545 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.39 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.11%

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Keywords:

Histone Acetyltransferase Inhibitor IIHistone AcetyltransferaseHATsHATHeLaH2B-EYFPacetylationanti-acetylasehistonesInhibitorinhibitorinhibit

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Product Name:
Histone Acetyltransferase Inhibitor II
Cat. No.:
HY-100734
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