2. Epigenetics
  3. Histone Acetyltransferase
  4. Histone Acetyltransferase Inhibitor II

Histone Acetyltransferase Inhibitor II 

Cat. No.: HY-100734 Purity: 99.01%
COA Handling Instructions

Histone Acetyltransferase Inhibitor II (compound 2c) is a potent, selective and cell permeable p300 histone acetyltransferase inhibitor, with an IC50 of 5 µM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells.

For research use only. We do not sell to patients.

Histone Acetyltransferase Inhibitor II Chemical Structure

Histone Acetyltransferase Inhibitor II Chemical Structure

CAS No. : 932749-62-7

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Solution
10 mM * 1 mL in DMSO USD 101 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 101 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 92 In-stock
Estimated Time of Arrival: December 31
10 mg USD 145 In-stock
Estimated Time of Arrival: December 31
25 mg USD 290 In-stock
Estimated Time of Arrival: December 31
50 mg USD 502 In-stock
Estimated Time of Arrival: December 31
100 mg USD 858 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Histone Acetyltransferase Inhibitor II (compound 2c) is a potent, selective and cell permeable p300 histone acetyltransferase inhibitor, with an IC50 of 5 µM. Histone Acetyltransferase Inhibitor II shows anti-acetylase activity in mammalian cells[1].

IC50 & Target

IC50：5 µM (p300 histone acetyltransferase)[1]
In Vitro

Histone Acetyltransferase Inhibitor II (20-40 μM) decreases the levels of H3 acetylation in HeLa-H2B-EYFP cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

464.15

Appearance

Solid

Formula

C20H16Br2O3
CAS No.
SMILES

O=C1/C(CCC/C1=C\C2=CC=C(O)C(Br)=C2)=C/C3=CC=C(O)C(Br)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (64.63 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1545 mL 10.7724 mL 21.5448 mL
5 mM 0.4309 mL 2.1545 mL 4.3090 mL
10 mM 0.2154 mL 1.0772 mL 2.1545 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.39 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.01%

COA (244 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Histone Acetyltransferase Inhibitor II932749-62-7Histone AcetyltransferaseHATsHATHeLaH2B-EYFPacetylationanti-acetylasehistonesInhibitorinhibitorinhibit

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