1. Epigenetics
    Neuronal Signaling
  2. Histone Demethylase
    Monoamine Oxidase

Vafidemstat (Synonyms: ORY-2001)

Cat. No.: HY-112623
Handling Instructions

Vafidemstat is a dual lysine-specific histone demethylase (LSD1)/MAO-B inhibitor.

For research use only. We do not sell to patients.

Vafidemstat Chemical Structure

Vafidemstat Chemical Structure

CAS No. : 1357362-02-7

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  • Biological Activity

  • Technical Information

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  • References

Description

Vafidemstat is a dual lysine-specific histone demethylase (LSD1)/MAO-B inhibitor.

IC50 & Target

LSD1/MAO-B[1]

In Vitro

Vafidemstat (ORY-2001), a dual LSD1/MAO-B inhibitor, is a novel epigenetic agent for the treatment of neurodegenerative diseases. LSD1 is a protein that participates in transcription regulation complexes; its modulation can be used to tweak transcriptional imbalances in neurodegenerative disease and redress neuroinflammation and cognitive deficit[1]. Vafidemstat (ORY-2001) can be used in the treatment of Alzheimer's disease[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9727 mL 14.8637 mL 29.7274 mL
5 mM 0.5945 mL 2.9727 mL 5.9455 mL
10 mM 0.2973 mL 1.4864 mL 2.9727 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

336.39

Formula

C₁₉H₂₀N₄O₂

CAS No.

1357362-02-7

SMILES

NC1=NN=C(O1)CN[[email protected]]2[[email protected]](C3=CC=C(OCC4=CC=CC=C4)C=C3)C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Vafidemstat
Cat. No.:
HY-112623
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Vafidemstat

Cat. No.: HY-112623