1. Epigenetics
    Neuronal Signaling
  2. Histone Demethylase
    Monoamine Oxidase
  3. Vafidemstat

Vafidemstat (Synonyms: ORY-2001)

Cat. No.: HY-112623
Handling Instructions

Vafidemstat (ORY-2001) is a dual lysine-specific histone demethylase (LSD1)/MAO-B inhibitor.

For research use only. We do not sell to patients.

Vafidemstat Chemical Structure

Vafidemstat Chemical Structure

CAS No. : 1357362-02-7

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Description

Vafidemstat (ORY-2001) is a dual lysine-specific histone demethylase (LSD1)/MAO-B inhibitor.

IC50 & Target

LSD1/MAO-B[1]

In Vitro

Vafidemstat (ORY-2001), a dual LSD1/MAO-B inhibitor, is a novel epigenetic agent for the treatment of neurodegenerative diseases. LSD1 is a protein that participates in transcription regulation complexes; its modulation can be used to tweak transcriptional imbalances in neurodegenerative disease and redress neuroinflammation and cognitive deficit[1]. Vafidemstat (ORY-2001) can be used in the treatment of Alzheimer's disease[2].

Clinical Trial
Molecular Weight

336.39

Formula

C₁₉H₂₀N₄O₂

CAS No.

1357362-02-7

SMILES

NC1=NN=C(O1)CN[[email protected]]2[[email protected]](C3=CC=C(OCC4=CC=CC=C4)C=C3)C2

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Vafidemstat
Cat. No.:
HY-112623
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