2. PROTAC Epigenetics
  3. PROTACs Histone Methyltransferase
  4. PROTAC EZH2 Degrader-10

PROTAC EZH2 Degrader-10 is a selective PROTAC protein degrader targeting EZH2. PROTAC EZH2 Degrader-10 can be used for the research of cancer.
(Pink: EZH2 ligand (HY-13470); Blue: Cereblon ligand (HY-103596); Black: linker).

For research use only. We do not sell to patients.

PROTAC EZH2 Degrader-10

PROTAC EZH2 Degrader-10 Chemical Structure

CAS No. : 2653338-60-2

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PROTAC EZH2 Degrader-10 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

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Description

PROTAC EZH2 Degrader-10 is a selective PROTAC protein degrader targeting EZH2. PROTAC EZH2 Degrader-10 can be used for the research of cancer[1]. (Pink: EZH2 ligand (HY-13470); Blue: Cereblon ligand (HY-103596); Black: linker).

In Vitro

PROTAC EZH2 Degrader-10 (compound1) inhibits EZH2 enzymatic activity (IC50 = 3.70 nM) with selectivity over EZH1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC EZH2 Degrader-10 Related Antibodies
Molecular Weight

854.99

Formula

C48H54N8O7
CAS No.
SMILES

CC[C@H](C)N1C=C(C)C2=C(C(NCC3=C(C)C=C(C)NC3=O)=O)C=C(C4=CN=C(N5CCN(CCCCOC6=C7C(N(C8CCC(NC8=O)=O)C(C7=CC=C6)=O)=O)CC5)C=C4)C=C21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC EZH2 Degrader-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC EZH2 Degrader-102653338-60-2PROTACsHistone MethyltransferaseH3K27me2/3 histone marksEZH2PRC2 complex subunitsEZH1cereblonE3 ubiquitin ligasecancer cellsproteasomal degradationubiquitinationInhibitorinhibitorinhibit

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