country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-181305

Copy Link Print Information

PROTAC EZH2 Degrader-10

PROTAC EZH2 Degrader-10 is a selective PROTAC protein degrader targeting EZH2. PROTAC EZH2 Degrader-10 can be used for the research of cancer.
(Pink: EZH2 ligand (HY-13470); Blue: Cereblon ligand (HY-103596); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 2653338-60-2
Formula: C₄₈H₅₄N₈O₇
Molecular Weight:854.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC EZH2 Degrader-10 Chemical Structure

CAS No.: 2653338-60-2

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC EZH2 Degrader-10 is a selective PROTAC protein degrader targeting EZH2. PROTAC EZH2 Degrader-10 can be used for the research of cancer^[1]. (Pink: EZH2 ligand (HY-13470); Blue: Cereblon ligand (HY-103596); Black: linker).

All PROTACs Isoforms :

All Histone Methyltransferase Isoforms :

In Vitro

PROTAC EZH2 Degrader-10 (compound1) inhibits EZH2 enzymatic activity (IC₅₀ = 3.70 nM) with selectivity over EZH1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2653338-60-2
Molecular Weight 854.99
Formula C₄₈H₅₄N₈O₇
SMILES

CC[C@H](C)N1C=C(C)C2=C(C(NCC3=C(C)C=C(C)NC3=O)=O)C=C(C4=CN=C(N5CCN(CCCCOC6=C7C(N(C8CCC(NC8=O)=O)C(C7=CC=C6)=O)=O)CC5)C=C4)C=C21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. S Abulkhair H, et al. Therapeutic horizons in the development of PROTAC-based EZH2 inhibitors: recent achievements, comparative analysis, and future perspectives. RSC Adv. 2026;16(4):3034-3056. Published 2026 Jan 14. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

PROTAC EZH2 Degrader-10

All PROTACs Isoforms

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC EZH2 Degrader-10 Related Classifications

HY-181305 Related Classifications