1. Metabolic Enzyme/Protease
    Anti-infection
  2. Dihydroorotate Dehydrogenase
    Parasite
  3. DSM265

DSM265 

Cat. No.: HY-100184 Purity: 99.72%
Handling Instructions

DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of Pf3D7 parasites with an EC50 of 4.3 nM.

For research use only. We do not sell to patients.

DSM265 Chemical Structure

DSM265 Chemical Structure

CAS No. : 1282041-94-4

Size Price Stock Quantity
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
25 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
250 mg USD 1000 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1850 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

DSM265 is a long-duration inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 of 8.9 nM. DSM265 can also inhibit the growth of Pf3D7 parasites with an EC50 of 4.3 nM[1][2].

IC50 & Target

IC50: 8.9 nM (PfDHODH)[1]
EC50: 4.3 nM (P. falciparum 3D7 parasites)[1]

In Vivo

DSM265 (0.5 to 75 mg/kg; Oral administration; twice daily; for 4 days; NOD-scid IL-2Rγnull (NSG) mice) has potent in vivo antimalarial activity with 90% effective dose (ED90) of 3 mg/kg per day (1.5 mg/kg twice daily). The maximum rate of parasite killing occurred at and above a dose of 13 mg/kg per day (6.4 mg/kg twice daily).
DSM265 has moderate terminal elimination half-life (t1/2) of 2-4 hours for mice (0.5 to 75 mg/kg, oral) [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD-scid IL-2Rγnull (NSG) mice (23-36 g)[2]
Dosage: 0.5 to 75 mg/kg
Administration: Oral administration; twice daily; for 4 days
Result: Had potent antimalarial activity with 90% effective dose (ED90) of 3 mg/kg per day (1.5 mg/kg twice daily).
Clinical Trial
Molecular Weight

415.33

Formula

C₁₄H₁₂F₇N₅S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (120.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4077 mL 12.0386 mL 24.0772 mL
5 mM 0.4815 mL 2.4077 mL 4.8154 mL
10 mM 0.2408 mL 1.2039 mL 2.4077 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (6.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (6.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
DSM265
Cat. No.:
HY-100184
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