1. Epigenetics
  2. Histone Methyltransferase
  3. E67-2

E67-2 

Cat. No.: HY-122746
Handling Instructions

E67-2, as the E67 derivative, is a low-toxicity, selective KIAA1718 Jumonji domain inhibitor with an IC50 value of 3.4 µM. E67-2 selectively inhibits histone H3 lysine 9 (H3K9) Jumonji demethylase as well as histone H3 lysine 4 (H3K4) demethylase.

For research use only. We do not sell to patients.

E67-2 Chemical Structure

E67-2 Chemical Structure

CAS No. : 1364914-62-4

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Description

E67-2, as the E67 derivative, is a low-toxicity, selective KIAA1718 Jumonji domain inhibitor with an IC50 value of 3.4 µM. E67-2 selectively inhibits histone H3 lysine 9 (H3K9) Jumonji demethylase as well as histone H3 lysine 4 (H3K4) demethylase[1].

IC50 & Target

IC50: 3.4 μM (H3K9 Jumonji demethylase)[1]

In Vitro

E67-2 (1~100 μM; 5 minutes) reduces inhibitory effect against GLP by a factor of approximately 1500, resulting in an IC50 of 75 µM. E67-2 has much reduced inhibition on PHF8 on the doubly methylated H3(1-24)K4me3K9me2 peptide substrate. E67-2 (100~100000 nM; 24 hours; fibroblasts) has significantly reduced cell toxicity [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

404.55

Formula

C₂₁H₃₆N₆O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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E67-2
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